Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy [0.03%]
利用冷冻冲击巨噬细胞伪装减毒沙门氏菌以实现肿瘤靶向治疗
Leyang Wu,Zengzheng Du,Lin Li et al.
Leyang Wu et al.
Live bacteria-mediated antitumor therapies mark a pivotal point in cancer immunotherapy. However, the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their application. Improving bacterial tumor-targeted...
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside [0.03%]
靶向治疗前蛋白转换酶枯草杆菌蛋白酶/儒林9型(PCSK9)：从实验台到病床边
Xuhui Bao,Yongjun Liang,Hanman Chang et al.
Xuhui Bao et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases (CVD). This comprehensive revi...
Meng Zhang,Qian Liu,Hui Meng et al.
Meng Zhang et al.
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury hinders the development of eff...
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity [0.03%]
JOSEDO2通过抑制LKB1活性促进肺癌的发生发展中
Tao Yuan,Chenming Zeng,Jiawei Liu et al.
Tao Yuan et al.
Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are suitable for and beneficial to...
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis [0.03%]
纠正：BICC1通过诱导非VEGF依赖的血管生成促进胰腺癌进展
Chongbiao Huang,Hui Li,Yang Xu et al.
Chongbiao Huang et al.
Published Erratum
Signal transduction and targeted therapy. 2024 Jan 5;9(1):8. DOI:10.1038/s41392-023-01721-z 2024
The role of inflammasomes in human diseases and their potential as therapeutic targets [0.03%]
炎症小体在人类疾病中的作用及其作为治疗靶点的潜力
Jing Yao,Keenan Sterling,Zhe Wang et al.
Jing Yao et al.
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected ...
Correction: The Hippo signalling pathway and its implications in human health and diseases [0.03%]
修正：Hippo信号通路及其对人类健康和疾病的影响
Minyang Fu,Yuan Hu,Tianxia Lan et al.
Minyang Fu et al.
Published Erratum
Signal transduction and targeted therapy. 2024 Jan 4;9(1):5. DOI:10.1038/s41392-023-01682-3 2024
Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets [0.03%]
淋巴管：起源、异质性、生物功能及治疗靶点
Zhaoliang Hu,Xushi Zhao,Zhonghua Wu et al.
Zhaoliang Hu et al.
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs. They are tasked with a serious of responsibilities, including the regulation...
Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets [0.03%]
细胞锌代谢及锌信号传导：从生物功能到疾病和治疗靶点
Bonan Chen,Peiyao Yu,Wai Nok Chan et al.
Bonan Chen et al.
Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellu...
Programmable synthetic receptors: the next-generation of cell and gene therapies [0.03%]
可编程合成受体：细胞和基因治疗的下一代技术
Fei Teng,Tongtong Cui,Li Zhou et al.
Fei Teng et al.
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy require to be further addressed in order to realize their full potential. Synthetic receptor...