Yuqing Mei,Jingjing Wang,Guoji Guo
Yuqing Mei
Yang Yang,Lu Guo,Lin Chen et al.
Yang Yang et al.
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear ...
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling [0.03%]
一种肿瘤富集小分子格姆博酸酰胺通过靶向WDR1依赖性细胞骨架重塑抑制胶质瘤
Jiaorong Qu,Bojun Qiu,Yuxin Zhang et al.
Jiaorong Qu et al.
Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients with malignant glioma and glioblastoma (GBM) have poor prognoses. The physical obstacle to drug delivery imposed by the blood‒brain barrier...
Ekaterina Pylaeva,Jadwiga Jablonska
Ekaterina Pylaeva
Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy [0.03%]
溴结构域和末端外结构域蛋白：生物学功能、相关疾病及靶向治疗研究进展
Zhi-Qiang Wang,Zhao-Cong Zhang,Yu-Yang Wu et al.
Zhi-Qiang Wang et al.
BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although preliminary clinical trials hav...
SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer [0.03%]
SUMO化触发的ALIX激活调控细胞外囊泡circTLCD4-RWDD3促进非小细胞肺癌淋巴转移
Xiayao Diao,Chao Guo,Hanhao Zheng et al.
Xiayao Diao et al.
Lymph node (LN) metastasis is one of the predominant metastatic routes of non-small cell lung cancer (NSCLC) and is considered as a leading cause for the unsatisfactory prognosis of patients. Although lymphangiogenesis is well-recognized as...
Leming Sun,Hongmei Liu,Yanqi Ye et al.
Leming Sun et al.
Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid prog...
Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial [0.03%]
针对半月板损伤的软骨再生增强型免疫调节细胞和基质调控细胞I期剂量递增试验
Liangjiang Huang,Song Zhang,Jun Wu et al.
Liangjiang Huang et al.
Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despi...
The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID [0.03%]
长期新冠的长期健康结局、病理生理机制及多学科管理
Jingwei Li,Yun Zhou,Jiechao Ma et al.
Jingwei Li et al.
There have been hundreds of millions of cases of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the growing population of recovered patients, it is crucial to under...