AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs) [0.03%]
Akt2S128/CCTαS315/319/323阳性的癌症相关成纤维细胞（CAFs）通过分泌卵磷脂（PCs）介导焦粘连激酶（FAK）抑制剂的耐药性
Jie Chen,Lingyuan Zhang,Yuheng Zhu et al.
Jie Chen et al.
Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics and lipidomics, to demonstrate that t...
Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor) [0.03%]
锌指和BTB结构域含18肝Zbtb18通过FXR减轻肝脂肪性肝炎
Lei Zhang,Jiabing Chen,Xiaoying Yang et al.
Lei Zhang et al.
A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms are not fully understood. Here,...
Jia Guo,Hanyi Zhang,Wenrui Lin et al.
Jia Guo et al.
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss [0.03%]
携带抗miR-6359-CGGGAGC的骨靶向工程化小细胞外囊泡预防丙戊酸诱导的骨丢失
Xudong Xie,Peng Cheng,Liangcong Hu et al.
Xudong Xie et al.
The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density (BMD) in both patients and...
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine [0.03%]
纠正：由锰纳米佐剂亚单位疫苗诱导的对SARS-CoV-2的持久和增强的免疫反应
Mengyu Guo,Mingjing Cao,Jiufeng Sun et al.
Mengyu Guo et al.
Lung microbiome: new insights into the pathogenesis of respiratory diseases [0.03%]
肺部微生物群系：对呼吸系统疾病发病机理的新认识
Ruomeng Li,Jing Li,Xikun Zhou
Ruomeng Li
The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community. The microbiome of healthy lungs is mainly derived from the upper respiratory tract (URT) microbiome but also has its ...
Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis [0.03%]
内狄化作用通过调节双阴性T细胞的稳态成为治疗狼疮的新疗法目标
Yun Zhang,Lijun Du,Chenxi Wang et al.
Yun Zhang et al.
Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells is considered as a cruci...
Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma [0.03%]
针对FCRL5的CAR-T细胞表现出对多发性骨髓瘤的抗肿瘤活性
Zhengyu Yu,Hexian Li,Qizhong Lu et al.
Zhengyu Yu et al.
Multiple myeloma (MM) remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell (CAR-T) therapy. Current targets of CAR-T cells used in MM immunotherapy have limitations, with a subset of patients...
Fei Tan,Xuran Li,Zhao Wang et al.
Fei Tan et al.
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Com...
Intratumoural microbiota: a new frontier in cancer development and therapy [0.03%]
肿瘤微生物群：癌症发生和治疗的新领域
Yaqi Cao,Hui Xia,Xueyun Tan et al.
Yaqi Cao et al.
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,...