Multifunctional mesoporous silica nanoparticles for biomedical applications [0.03%]
用于生物医学应用的多功能介孔二氧化硅纳米粒子
Bolong Xu,Shanshan Li,Rui Shi et al.
Bolong Xu et al.
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent b...
γδ T cells: origin and fate, subsets, diseases and immunotherapy [0.03%]
gamma delta T细胞：起源和归宿、亚群、疾病与免疫治疗
Yi Hu,Qinglin Hu,Yongsheng Li et al.
Yi Hu et al.
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus ...
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets [0.03%]
缺氧引起的血管信号传导：起因、发病机理及治疗目标
Yongchao Zhao,Weidong Xiong,Chaofu Li et al.
Yongchao Zhao et al.
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to ...
Versatile guardians: regenerative regulatory T cells in Parkinson's disease rodent models [0.03%]
多才多艺的守护者：帕金森病啮齿动物模型中的再生调节性T细胞
Chi Wang Ip,Jörg Wischhusen
Chi Wang Ip
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer [0.03%]
预测PD-L1抑制剂巴替利单抗(TQB2450)联合抗血管生成药物安罗替尼治疗三阴乳腺癌患者的疗效及生存的生物标志物研究
Yiqun Han,Jiayu Wang,Tao Sun et al.
Yiqun Han et al.
In our phase Ib trial (ClinialTrials.gov Identifier: NCT03855358), benmelstobart (TQB2450), a novel humanized IgG1 antibody against PD-L1, plus antiangiogenic multikinase inhibitor, anlotinib, demonstrated promising antitumor activities in ...
Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β [0.03%]
新型自噬诱导剂微小隆素H通过靶向磷脂转运蛋白PITPα/β发挥强大的抗肿瘤活性
Hange Yang,Xiaowei Zhang,Cong Wang et al.
Hange Yang et al.
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy. The phosphatidylinositol transfer protein alpha/beta isoform (PITPα/β) has been reported to play an essentia...
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases [0.03%]
转录共激活因子：在信号通路中的新角色及其可能成为疾病的治疗靶点
Priyanka Dey Talukdar,Urmi Chatterji
Priyanka Dey Talukdar
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators. Deregulation of these regulatory molecules i...
Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients [0.03%]
重症监护病房中奥密克戎患者机械通气期间人肺微生物群的元转录组分析
Lin Wang,Jia-Bao Cao,Bin-Bin Xia et al.
Lin Wang et al.
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the disease and fatality is valuable...