Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines [0.03%]
灭活疫苗接种成人异源加强接种重组新冠疫苗（Sf9细胞）的安全性、免疫原性和保护效力研究
Wenxin Luo,Jiadi Gan,Zhu Luo et al.
Wenxin Luo et al.
Vaccines have proven effective in protecting populations against COVID-19, including the recombinant COVID-19 vaccine (Sf9 cells), the first approved recombinant protein vaccine in China. In this positive-controlled trial with 85 adult part...
Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity [0.03%]
靶向SARS-CoV-2核衣壳蛋白的适体表现出潜在的广谱抗冠状病毒活性
Minghui Yang,Chunhui Li,Guoguo Ye et al.
Minghui Yang et al.
Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health security. In light of this ongoing threat, the development of a broad-spectrum drug to combat HCo...
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy [0.03%]
对接蛋白6(DOK6)选择性对接神经营养信号转导以抑制周围神经病
Yan Guo,Pan Xiang,Xiaojiao Sun et al.
Yan Guo et al.
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits, and this process requires the proper recruitment of adaptor molecules to selectively activa...
Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma [0.03%]
营养素限制激活的Fra-2通过miR-15a下调的IGF1R促进胰管腺癌的发展
Gian Luca Rampioni Vinciguerra,Marina Capece,Luca Reggiani Bonetti et al.
Gian Luca Rampioni Vinciguerra et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to...
Lulu Cui,Shu Li,Siman Wang et al.
Lulu Cui et al.
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological ...
Discovering deaminases using AlphaFold2: a strategy to search for tool proteins for gene editing [0.03%]
使用AlphaFold2发现脱氨酶：寻找基因编辑工具蛋白的策略
Yongye Huang,Jianxin Jiang,Min Wu
Yongye Huang
DNA framework signal amplification platform-based high-throughput systemic immune monitoring [0.03%]
基于DNA框架信号放大平台的高通量系统免疫监测
Ye Chen,Xingyu Chen,Bowen Zhang et al.
Ye Chen et al.
Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of immune cells. However, conventional immune monitoring using flow cytometry faces huge challenges...
Mudasir A Kumar,Sadaf K Baba,Hana Q Sadida et al.
Mudasir A Kumar et al.
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological condi...
Alternative splicing and related RNA binding proteins in human health and disease [0.03%]
可变剪切及相关的RNA结合蛋白在人类健康和疾病中的作用
Yining Tao,Qi Zhang,Haoyu Wang et al.
Yining Tao et al.
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specif...
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study [0.03%]
在晚期非小细胞肺癌中进行化疗，加上或不加贝伐单抗的QL1706（抗PD-1 IgG4/CTLA-4抗体）：多队列、二期研究
Yan Huang,Yunpeng Yang,Yuanyuan Zhao et al.
Yan Huang et al.
First-line chemoimmunotherapy (with or without bevacizumab) has improved outcomes in advanced non-small cell lung cancer (NSCLC). Here, this open-label, multi-cohort phase II study (NCT05329025) was done to investigate the safety and effica...