Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis [0.03%]
Trim25通过ROS平衡抑制ITPKB降解从而赋予胶质母细胞瘤TMZ耐药性
Yuanliang Yan,Shangjun Zhou,Xi Chen et al.
Yuanliang Yan et al.
Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of drug resistance constitutes a significant hurdle in the treatment of malignant glioma. Although specific innovative a...
NF-κB in biology and targeted therapy: new insights and translational implications [0.03%]
NF-κB在生物学及针对性治疗中的新见解与应用前景
Qing Guo,Yizi Jin,Xinyu Chen et al.
Qing Guo et al.
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered ...
Eliciting CD4-mimicking broadly neutralizing antibodies: new avenues towards the rational design of an HIV vaccine [0.03%]
诱导CD4模仿的广谱中和抗体：艾滋病疫苗合理设计的新途径
Frauke Muecksch,Oliver T Fackler
Frauke Muecksch
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases [0.03%]
过氧化物酶体增殖激活受体γ共激活因子1（PGC-1）家族在生理和病理过程及疾病中的作用
Lu Qian,Yanli Zhu,Chao Deng et al.
Lu Qian et al.
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s a...
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes [0.03%]
接触蛋白相关蛋白样2（CNTNAP2）突变会损害必需的α-分泌酶裂解，导致类似自闭症的表型
Qing Zhang,Mengen Xing,Zhengkai Bao et al.
Qing Zhang et al.
Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key enzymes involved in the C-term...
Resilience conferred by APOE-R136S: a defense bestowed by nature to combat Alzheimer's disease [0.03%]
APOE-R136S带来的韧性：大自然赋予的对抗阿尔茨海默病的防御机制
Bin Xiao,Joshua Kuruvilla,Eng-King Tan
Bin Xiao
Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity [0.03%]
嗜酸性粒细胞促进CD8阳性T细胞记忆生成以增强抗细菌免疫能力
Jun Zhou,Jiaqi Liu,Bingjing Wang et al.
Jun Zhou et al.
Memory CD8+ T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular and molecular circuitry that underlies the generation of memory CD8+ T cells remains elusive. Eosinophils can modula...
Hao Dong,Yuezhang Sun,Lulingxiao Nie et al.
Hao Dong et al.
Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment, such as ...
Precise genome-editing in human diseases: mechanisms, strategies and applications [0.03%]
精准基因编辑在人类疾病中的应用：机制、策略及应用范围
Yanjiang Zheng,Yifei Li,Kaiyu Zhou et al.
Yanjiang Zheng et al.
Precise genome-editing platforms are versatile tools for generating specific, site-directed DNA insertions, deletions, and substitutions. The continuous enhancement of these tools has led to a revolution in the life sciences, which promises...