Mpox (formerly monkeypox): pathogenesis, prevention, and treatment [0.03%]
猴痘（以前称为monkeypox）：发病机理、预防与治疗
Junjie Lu,Hui Xing,Chunhua Wang et al.
Junjie Lu et al.
In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions. The World Health Organization declared the outbreak to be a public he...
Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape [0.03%]
CAR分子的吞细胞作用调节CAR-T细胞功能障碍和肿瘤抗原逃逸
You Zhai,Yicong Du,Guanzhang Li et al.
You Zhai et al.
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in animal models and clinical tria...
New insights into the correlations between circulating tumor cells and target organ metastasis [0.03%]
循环肿瘤细胞与靶器官转移之间关联的新见解
Qinru Zhan,Bixia Liu,Xiaohua Situ et al.
Qinru Zhan et al.
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironmen...
Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period [0.03%]
大流行后期开发和批准COVID-19疫苗和疗法的策略
Danyi Ao,Xuemei He,Jian Liu et al.
Danyi Ao et al.
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and social unrest. In response, vario...
Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer [0.03%]
吡咯替尼和金丝桃素在HER2阳性乳腺癌中具有协同促进自噬的作用
Xiaoxiao Liu,Xing Zhang,Zhiying Shao et al.
Xiaoxiao Liu et al.
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has been the most challenging subtype of BC, consisting of 20% of BC with an apparent correlation with poor prognosis. Despite that pyrotinib, a new HER2 inhibitor,...
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies [0.03%]
针对RAS/RAF/MAPK通路的肿瘤治疗：从机制研究到临床试验
Md Entaz Bahar,Hyun Joon Kim,Deok Ryong Kim
Md Entaz Bahar
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic ...
Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis [0.03%]
同时靶向细胞外囊泡转运和TGF-β受体激酶活性可抑制信号过度活化和转移
Adilson Fonseca Teixeira,Yanhong Wang,Josephine Iaria et al.
Adilson Fonseca Teixeira et al.
Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly enhanced during cancer progression. Yet, the use of on-target TGF-β signaling inhibitors in the ...
Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine [0.03%]
锰纳米佐剂修饰亚单位疫苗诱导的持久增强型抗SARS-CoV-2免疫反应
Mengyu Guo,Mingjing Cao,Jiufeng Sun et al.
Mengyu Guo et al.
Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system [0.03%]
长期COVID-19：SARS-CoV-2感染对先天性免疫系统的影响
Marianne Boes,Pascal Falter-Braun
Marianne Boes