Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis [0.03%]
内狄化作用通过调节双阴性T细胞的稳态成为治疗狼疮的新疗法目标
Yun Zhang,Lijun Du,Chenxi Wang et al.
Yun Zhang et al.
Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells is considered as a cruci...
Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma [0.03%]
针对FCRL5的CAR-T细胞表现出对多发性骨髓瘤的抗肿瘤活性
Zhengyu Yu,Hexian Li,Qizhong Lu et al.
Zhengyu Yu et al.
Multiple myeloma (MM) remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell (CAR-T) therapy. Current targets of CAR-T cells used in MM immunotherapy have limitations, with a subset of patients...
Fei Tan,Xuran Li,Zhao Wang et al.
Fei Tan et al.
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Com...
Intratumoural microbiota: a new frontier in cancer development and therapy [0.03%]
肿瘤微生物群：癌症发生和治疗的新领域
Yaqi Cao,Hui Xia,Xueyun Tan et al.
Yaqi Cao et al.
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,...
Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy [0.03%]
利用冷冻冲击巨噬细胞伪装减毒沙门氏菌以实现肿瘤靶向治疗
Leyang Wu,Zengzheng Du,Lin Li et al.
Leyang Wu et al.
Live bacteria-mediated antitumor therapies mark a pivotal point in cancer immunotherapy. However, the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their application. Improving bacterial tumor-targeted...
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside [0.03%]
靶向治疗前蛋白转换酶枯草杆菌蛋白酶/儒林9型(PCSK9)：从实验台到病床边
Xuhui Bao,Yongjun Liang,Hanman Chang et al.
Xuhui Bao et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases (CVD). This comprehensive revi...
Meng Zhang,Qian Liu,Hui Meng et al.
Meng Zhang et al.
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury hinders the development of eff...
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity [0.03%]
JOSEDO2通过抑制LKB1活性促进肺癌的发生发展中
Tao Yuan,Chenming Zeng,Jiawei Liu et al.
Tao Yuan et al.
Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are suitable for and beneficial to...
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis [0.03%]
纠正：BICC1通过诱导非VEGF依赖的血管生成促进胰腺癌进展
Chongbiao Huang,Hui Li,Yang Xu et al.
Chongbiao Huang et al.
Published Erratum
Signal transduction and targeted therapy. 2024 Jan 5;9(1):8. DOI:10.1038/s41392-023-01721-z 2024
The role of inflammasomes in human diseases and their potential as therapeutic targets [0.03%]
炎症小体在人类疾病中的作用及其作为治疗靶点的潜力
Jing Yao,Keenan Sterling,Zhe Wang et al.
Jing Yao et al.
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected ...