RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy [0.03%]
细胞代谢中的RNA修饰：对代谢靶向疗法和免疫疗法的影响
Wei-Wei Liu,Si-Qing Zheng,Tian Li et al.
Wei-Wei Liu et al.
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeut...
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses [0.03%]
针对正痘病毒的双靶点mRNA抗体鸡尾酒疗法的快速开发
Hang Chi,Suo-Qun Zhao,Ru-Yi Chen et al.
Hang Chi et al.
The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost o...
First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study [0.03%]
斯鲁利单抗联合阿帕替尼和化疗一线治疗晚期胃癌的一项I期研究(SPACE研究)
Xiaofeng Chen,Hao Xu,Xiaobing Chen et al.
Xiaofeng Chen et al.
Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapy for advanc...
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl- concentration [0.03%]
SARS-CoV-2包膜蛋白通过增加细胞内氯离子浓度损害气道上皮屏障功能并加重气道炎症反应
Jian-Bang Xu,Wei-Jie Guan,Yi-Lin Zhang et al.
Jian-Bang Xu et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope (E) protein, a core virulence structural component of coronaviruses, may play a role in th...
Ankang Hu,Li Sun,Hao Lin et al.
Ankang Hu et al.
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in innate immune cells but also in adaptive immune cells, tumor cells, and stromal cells. Agonists...
Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses [0.03%]
纠正：c-Myc驱动的糖酵解极化功能调控B细胞触发致病性炎症反应
Xu-Yan Wang,Yuan Wei,Bo Hu et al.
Xu-Yan Wang et al.
Shubhangi Gavali,Francesca Maremonti,Andreas Linkermann
Shubhangi Gavali
Ziqin Deng,Tao Fan,Chu Xiao et al.
Ziqin Deng et al.
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly critical to embryonic developme...
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication [0.03%]
健康与疾病中的蛋白质脂化：分子机制，生理功能和病理意义
Yuan Yuan,Peiyuan Li,Jianghui Li et al.
Yuan Yuan et al.
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes. Among these, protein lipidations which refer to lipid attachment to proteins are prom...
Diabetes and pulmonary infection: how hyperglycaemia shapes the immune system [0.03%]
糖尿病与肺部感染：高血糖如何影响免疫系统
Christian Herder,Michael Roden,Nicolas Venteclef
Christian Herder