DNA framework signal amplification platform-based high-throughput systemic immune monitoring [0.03%]
基于DNA框架信号放大平台的高通量系统免疫监测
Ye Chen,Xingyu Chen,Bowen Zhang et al.
Ye Chen et al.
Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of immune cells. However, conventional immune monitoring using flow cytometry faces huge challenges...
Mudasir A Kumar,Sadaf K Baba,Hana Q Sadida et al.
Mudasir A Kumar et al.
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological condi...
Alternative splicing and related RNA binding proteins in human health and disease [0.03%]
可变剪切及相关的RNA结合蛋白在人类健康和疾病中的作用
Yining Tao,Qi Zhang,Haoyu Wang et al.
Yining Tao et al.
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specif...
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study [0.03%]
在晚期非小细胞肺癌中进行化疗，加上或不加贝伐单抗的QL1706（抗PD-1 IgG4/CTLA-4抗体）：多队列、二期研究
Yan Huang,Yunpeng Yang,Yuanyuan Zhao et al.
Yan Huang et al.
First-line chemoimmunotherapy (with or without bevacizumab) has improved outcomes in advanced non-small cell lung cancer (NSCLC). Here, this open-label, multi-cohort phase II study (NCT05329025) was done to investigate the safety and effica...
AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs) [0.03%]
Akt2S128/CCTαS315/319/323阳性的癌症相关成纤维细胞（CAFs）通过分泌卵磷脂（PCs）介导焦粘连激酶（FAK）抑制剂的耐药性
Jie Chen,Lingyuan Zhang,Yuheng Zhu et al.
Jie Chen et al.
Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics and lipidomics, to demonstrate that t...
Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor) [0.03%]
锌指和BTB结构域含18肝Zbtb18通过FXR减轻肝脂肪性肝炎
Lei Zhang,Jiabing Chen,Xiaoying Yang et al.
Lei Zhang et al.
A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms are not fully understood. Here,...
Jia Guo,Hanyi Zhang,Wenrui Lin et al.
Jia Guo et al.
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss [0.03%]
携带抗miR-6359-CGGGAGC的骨靶向工程化小细胞外囊泡预防丙戊酸诱导的骨丢失
Xudong Xie,Peng Cheng,Liangcong Hu et al.
Xudong Xie et al.
The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density (BMD) in both patients and...
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine [0.03%]
纠正：由锰纳米佐剂亚单位疫苗诱导的对SARS-CoV-2的持久和增强的免疫反应
Mengyu Guo,Mingjing Cao,Jiufeng Sun et al.
Mengyu Guo et al.
Lung microbiome: new insights into the pathogenesis of respiratory diseases [0.03%]
肺部微生物群系：对呼吸系统疾病发病机理的新认识
Ruomeng Li,Jing Li,Xikun Zhou
Ruomeng Li
The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community. The microbiome of healthy lungs is mainly derived from the upper respiratory tract (URT) microbiome but also has its ...