Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis [0.03%]
循环肿瘤细胞通过来源于细胞外囊泡的CD45屏蔽以躲避T细胞攻击并发生转移
Chuan Yang,Xueping Wang,Kenneth K W To et al.
Chuan Yang et al.
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for thera...
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance [0.03%]
乳腺导管原位癌进展为侵犯性乳腺癌的分子特征及其临床意义
Jing Wang,Baizhou Li,Meng Luo et al.
Jing Wang et al.
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25-60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in distinguishing between non-progressive and progressive DCIS, often ...
Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer [0.03%]
中性粒细胞的形态由肿瘤微环境塑造：癌症中靶向中性粒细胞的新思路
Carlos Silvestre-Roig,Lydia Kalafati,Triantafyllos Chavakis
Carlos Silvestre-Roig
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial [0.03%]
卡培他滨和奥沙利铂联合贝伐珠单抗（血管生成抑制剂）并有或没有过继性细胞免疫治疗新诊断的转移性结直肠癌患者：一项多中心、开放标签、随机对照III期临床试验
Qiu-Zhong Pan,Jing-Jing Zhao,Liang Liu et al.
Qiu-Zhong Pan et al.
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT0395015...
Optimizing oncolytic virus design: a "Swiss army knife" approach to create a systemically delivered therapeutic [0.03%]
优化溶瘤病毒设计：创建可全身递送的治疗性“瑞士军刀”系统
Carolina S Ilkow,John Cameron Bell
Carolina S Ilkow
Adeno-associated virus as a delivery vector for gene therapy of human diseases [0.03%]
腺相关病毒作为人类疾病基因治疗的载体病毒
Jiang-Hui Wang,Dominic J Gessler,Wei Zhan et al.
Jiang-Hui Wang et al.
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been enginee...
Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance [0.03%]
大环肽：对抗抗生素抗性的新兴武器
Wen-Jing Wang,Xiang-Min Dong,Guo-Bo Li
Wen-Jing Wang
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy [0.03%]
Mex-3家族RNA结合成员A（MEX3A）/环状MPP6复合体通过抑制自噬促进结直肠癌进展
Ri-Xin Chen,Shui-Dan Xu,Min-Hua Deng et al.
Ri-Xin Chen et al.
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in colorectal cancer (CRC) are still ...
Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response [0.03%]
玩弄癌症治疗：如何通过黑色素瘤表型预测检查点抑制剂的反应
Svenja Meierjohann,Corine Bertolotto
Svenja Meierjohann
The two sides of chromosomal instability: drivers and brakes in cancer [0.03%]
染色体不稳定的两面：癌症中的驱动因素与制动因素
Rendy Hosea,Sharon Hillary,Sumera Naqvi et al.
Rendy Hosea et al.
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or struc...