Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects [0.03%]
溶瘤病毒与T细胞或mRNA疫苗联合治疗可增强抗肿瘤作用
Rao Fu,Ruoyao Qi,Hualong Xiong et al.
Rao Fu et al.
Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it difficult to achieve desired antitu...
Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring [0.03%]
胆管癌合并胆道梗阻：用于诊断和早期复发监测的外泌体环状circRNA标志物签名
Ningyuan Wen,Dingzhong Peng,Xianze Xiong et al.
Ningyuan Wen et al.
Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic approaches. We present a novel system to monitor CCA using exosomal circular RNA (circRNA) via serum and biliary liquid ...
Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy [0.03%]
利用自然发生的突变进行T细胞治疗：提高治疗有效性的潜在新途径
Michael Hiltensperger,Jürgen Ruland,Kilian Schober
Michael Hiltensperger
Two hits are better than one: rational dual strategy efficiently fights neuroblastoma [0.03%]
一石二鸟：理性双重策略有效对抗神经母细胞瘤
Jacques Zimmer,Camille Rolin,Markus Ollert
Jacques Zimmer
Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications [0.03%]
METTL14在代谢紊乱相关性脂肪肝病中作用的解析：见解与治疗启示
So Jung Kim,Jeongeun Hyun
So Jung Kim
A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology [0.03%]
异柠檬酸脱氢酶3β对数中基因6的正反馈抑制促进类似阿尔茨海默病的病理变化
Xin Wang,Qian Liu,Hai-Tao Yu et al.
Xin Wang et al.
Impaired brain glucose metabolism is an early indicator of Alzheimer's disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical tr...
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1 [0.03%]
含有鞭毛蛋白的三聚体RBD支架蛋白鼻粘膜免疫可诱导对包括JN.1变异株在内的多种SARS-CoV-2变异株的长期保护力
Xian Li,Mengxin Xu,Jingyi Yang et al.
Xian Li et al.
Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (...
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications [0.03%]
诱导多能干细胞(iPSCs)：诱导的分子机制及其应用
Jonas Cerneckis,Hongxia Cai,Yanhong Shi
Jonas Cerneckis
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, ...
Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment [0.03%]
用于CAR-T细胞的Cas13d介导基因敲低：迈向通用型癌症治疗疗法
Midori Johnston,Nadine Urban,Can Dincer
Midori Johnston
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets [0.03%]
胆酸代谢和信号转导的生理和病理机制及治疗靶点：分子机制及治疗靶点
Joshua S Fleishman,Sunil Kumar
Joshua S Fleishman
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro-inflammatory/anti-inflammatory balance. Bile acid metabolism and signali...