Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior [0.03%]
外周免疫细胞源性基质金属蛋白酶8(MMP8)：脑内递送促进类似抑郁的行为反应
Dietmar Spengler,Theo Rein
Dietmar Spengler
Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities [0.03%]
药理免疫调节抗癌药物的研发：当前的机制研究及临床应用机遇
Nanhao Yin,Xintong Li,Xuanwei Zhang et al.
Nanhao Yin et al.
Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncology, an increasing number of nov...
Yue Zhou,Lei Tao,Jiahao Qiu et al.
Yue Zhou et al.
Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognos...
Xiang Wei,Fangfang Zhou,Long Zhang
Xiang Wei
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends togethe...
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study [0.03%]
斯鲁利单抗（PD-1抗体）联合希维普替尼（组蛋白脱乙酰酶抑制剂）治疗复发或难治性结外NK/T细胞淋巴瘤患者：Ib/II期临床研究(SCENT)
Yan Gao,Haixia He,Xueping Li et al.
Yan Gao et al.
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete response (CR) rate and the duration of response (DOR) need to be improved. This phase 1b/2...
Yao Zong,Hao Li,Peng Liao et al.
Yao Zong et al.
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in many common pathologies, includin...
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis [0.03%]
2-APQC通过调节线粒体稳态缓解心肌肥大和纤维化：一种激活Sirtuin-3(SIRT3)的small-molecule激活剂
Fu Peng,Minru Liao,Wenke Jin et al.
Fu Peng et al.
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently...
Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain [0.03%]
一种针对SARS-CoV-2刺突蛋白N端结构域保守表位的IgM样纳米抗体增强效力
Bo Liu,Honghui Liu,Pu Han et al.
Bo Liu et al.
Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such a...