Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes [0.03%]
早期胰岛素治疗对新诊断的2型糖尿病患者心血管事件发生率的现实世界有效性研究
Sihui Luo,Xueying Zheng,Wei Bao et al.
Sihui Luo et al.
Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. In this nationwide real-world s...
First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial [0.03%]
培米单抗（PD-1抗体）和阿帕替尼（血管生成抑制剂）与白蛋白紫杉醇/吉西他滨在转移性胰腺癌中的应用：一项前瞻性多中心生物分子探索Ⅱ期临床试验
Huizi Sha,Fan Tong,Jiayao Ni et al.
Huizi Sha et al.
Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcita...
Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade [0.03%]
特异性FAP放射配体治疗联合免疫点抑制的抗肿瘤效果及潜在机制研究
Liang Zhao,Yizhen Pang,Yangfan Zhou et al.
Liang Zhao et al.
Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast activation protein (FAP)-targeti...
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets [0.03%]
心血管疾病的巨噬细胞：分子机制和治疗靶点
Runkai Chen,Hongrui Zhang,Botao Tang et al.
Runkai Chen et al.
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that occurs following cardiovascular i...
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration [0.03%]
靶向BCL9/BCL9L通过促进经典I型树突状细胞活化和肿瘤浸润来增强抗原呈递
Fenglian He,Zhongen Wu,Chenglong Liu et al.
Fenglian He et al.
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against...
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding [0.03%]
冠状病毒2'-O-甲基转移酶活性的天然证据影响病毒感染性通过改善底物RNA结合能力实现
Jikai Deng,Shimin Yang,Yingjian Li et al.
Jikai Deng et al.
Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2'-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif of 2'-O-MTase is highly conserve...
Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection [0.03%]
初始严重程度的新冠病毒感染受人冠状病毒特异性T细胞印记影响，并与再感染呈反比关系
Gang Yang,Jinpeng Cao,Jian Qin et al.
Gang Yang et al.
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain unclarified. Here, we longitudinall...
Molecular insights of exercise therapy in disease prevention and treatment [0.03%]
运动疗法在疾病预防和治疗中的分子机制研究
David Walzik,Tiffany Y Wences Chirino,Philipp Zimmer et al.
David Walzik et al.
Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases, the underlying biological mechanisms have not been fully elucidated. Several exercise benefits have been att...
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies [0.03%]
诺瑟信号通路与癌症：从机制研究到靶向治疗
Qingmiao Shi,Chen Xue,Yifan Zeng et al.
Qingmiao Shi et al.
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing e...
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure [0.03%]
DEAD盒解旋酶17（DDX17）通过促进心力衰竭中的线粒体稳态来保护心脏功能
Mingjing Yan,Junpeng Gao,Ming Lan et al.
Mingjing Yan et al.
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-...