SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl- concentration [0.03%]
SARS-CoV-2包膜蛋白通过增加细胞内氯离子浓度损害气道上皮屏障功能并加重气道炎症反应
Jian-Bang Xu,Wei-Jie Guan,Yi-Lin Zhang et al.
Jian-Bang Xu et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope (E) protein, a core virulence structural component of coronaviruses, may play a role in th...
Ankang Hu,Li Sun,Hao Lin et al.
Ankang Hu et al.
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in innate immune cells but also in adaptive immune cells, tumor cells, and stromal cells. Agonists...
Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses [0.03%]
纠正：c-Myc驱动的糖酵解极化功能调控B细胞触发致病性炎症反应
Xu-Yan Wang,Yuan Wei,Bo Hu et al.
Xu-Yan Wang et al.
Shubhangi Gavali,Francesca Maremonti,Andreas Linkermann
Shubhangi Gavali
Ziqin Deng,Tao Fan,Chu Xiao et al.
Ziqin Deng et al.
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly critical to embryonic developme...
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication [0.03%]
健康与疾病中的蛋白质脂化：分子机制，生理功能和病理意义
Yuan Yuan,Peiyuan Li,Jianghui Li et al.
Yuan Yuan et al.
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes. Among these, protein lipidations which refer to lipid attachment to proteins are prom...
Diabetes and pulmonary infection: how hyperglycaemia shapes the immune system [0.03%]
糖尿病与肺部感染：高血糖如何影响免疫系统
Christian Herder,Michael Roden,Nicolas Venteclef
Christian Herder
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease [0.03%]
上调的Kallistatin促进非酒精性脂肪肝疾病的产生与发展
Zhenzhen Fang,Gang Shen,Yina Wang et al.
Zhenzhen Fang et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and the development of non-alcoholic steatohepatitis (NASH) might cause irreversible hepatic damage. Hyperlipidemia (HLP) is the leading risk fact...
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential [0.03%]
饮食干预对人类疾病的影响：分子机制和治疗潜力
Yu-Ling Xiao,Yue Gong,Ying-Jia Qi et al.
Yu-Ling Xiao et al.
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for ne...
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study [0.03%]
PD-1阻断联合长疗程化放疗在局部晚期直肠癌中的疗效和安全性(NECTAR)：多中心2期研究
Zhengyang Yang,Jiale Gao,Jianyong Zheng et al.
Zhengyang Yang et al.
Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer (LARC) patients with microsatellite stable (MSS) / mismatch repair-proficient (pMMR) tumors is an attractive, but debatable strategy. This phase 2, multicen...