Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3'-isoforms, displaying an altered expression in breast cancer [0.03%]
多聚腺苷酸特异性核糖核酸酶（PARN）生成和调节miR-125a-5p 3'同工型，并在乳腺癌中表达改变
Luisa Tomasello,Shoshanah M Holub,Giovanni Nigita et al.
Luisa Tomasello et al.
Chunling Wang,Junchao Xu,Xiaoyu Cheng et al.
Chunling Wang et al.
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various strategies aiming at regulating th...
Wei Deng,Linlin Bao,Zhiqi Song et al.
Wei Deng et al.
Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SAR...
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery [0.03%]
G蛋白偶联受体(GPCRs)：结构、机制及药物发现研究进展
Mingyang Zhang,Ting Chen,Xun Lu et al.
Mingyang Zhang et al.
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric...
Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity [0.03%]
硫胺素修饰的人多能干细胞源心肌细胞在空间微重力下的代谢重组
Xinglong Han,Lina Qu,Miao Yu et al.
Xinglong Han et al.
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morphology, physiology, metabolism, and...
Chenglong Zhu,Sheng Xu,Ruoyu Jiang et al.
Chenglong Zhu et al.
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is pivotal in orchestrating proce...
Shizhen Zhang,Qing Yu,Zhijian Li et al.
Shizhen Zhang et al.
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation, catalyzed by the enz...
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis [0.03%]
循环肿瘤细胞通过来源于细胞外囊泡的CD45屏蔽以躲避T细胞攻击并发生转移
Chuan Yang,Xueping Wang,Kenneth K W To et al.
Chuan Yang et al.
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for thera...
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance [0.03%]
乳腺导管原位癌进展为侵犯性乳腺癌的分子特征及其临床意义
Jing Wang,Baizhou Li,Meng Luo et al.
Jing Wang et al.
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25-60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in distinguishing between non-progressive and progressive DCIS, often ...
Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer [0.03%]
中性粒细胞的形态由肿瘤微环境塑造：癌症中靶向中性粒细胞的新思路
Carlos Silvestre-Roig,Lydia Kalafati,Triantafyllos Chavakis
Carlos Silvestre-Roig