Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases [0.03%]
抑制蛋白酶体和WEE家族激酶协同诱导有丝分裂焦亡和抗肿瘤效应
Zhan-Li Chen,Chen Xie,Wei Zeng et al.
Zhan-Li Chen et al.
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasome-mediated protein degradation ...
Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy [0.03%]
prosaposin岩藻糖基化：一种新的肿瘤免疫逃逸机制及其对癌症免疫治疗的启示
Matthias Peipp,Diana Dudziak,Christian Kellner
Matthias Peipp
Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway [0.03%]
人工智能邂逅身体意识：任务驱动型神经网络揭示本体感觉通路的计算原理
Leonard E van Dyck,Frank Bremmer,Katharina Dobs
Leonard E van Dyck
A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori [0.03%]
基于深度学习的抗多重耐药幽门螺杆菌伯克敏衍生物的新抗菌剂发现研究
Xixi Guo,Xiaosa Zhao,Xi Lu et al.
Xixi Guo et al.
Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep learni...
Cancer stem cells: advances in knowledge and implications for cancer therapy [0.03%]
癌症干细胞：知识进展及其对癌症治疗的影响
Xianjing Chu,Wentao Tian,Jiaoyang Ning et al.
Xianjing Chu et al.
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity. Cancer continues to be a significant globa...
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression [0.03%]
基质衍生的分泌因子セマフォリン3C重塑肿瘤微环境促进肝癌进展的功能与机制研究
Hao Peng,Meng Yang,Kun Feng et al.
Hao Peng et al.
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-associated fibroblasts (CAFs) a...
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure [0.03%]
促进肝再生：激酶抑制剂预防肝衰新的武器
Anna Sichler,Norbert Hüser,Klaus-Peter Janssen
Anna Sichler
Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study [0.03%]
儿童饮食蛋白质来源、肠道微生物组和青春期发育时间：一项队列研究的结果
Yujie Xu,Jingyuan Xiong,Xiaoyu Wang et al.
Yujie Xu et al.
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions [0.03%]
水凝胶的潜在医疗应用：现状与未来方向研究进展
Peilin Lu,Dongxue Ruan,Meiqi Huang et al.
Peilin Lu et al.
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in the...
Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma [0.03%]
阿法替尼（酪氨酸激酶抑制剂）治疗EGFR高表达的食管鳞癌细胞株的临床疗效及其耐药相关因素的鉴定
Yanni Wang,Chang Liu,Huan Chen et al.
Yanni Wang et al.
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor ac...