Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial [0.03%]
人脐带间充质干细胞治疗难治性免疫性血小板减少症的疗效和安全性：一项前瞻性、单组、Ⅰ期临床试验
Yunfei Chen,Yanmei Xu,Ying Chi et al.
Yunfei Chen et al.
Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising...
Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial [0.03%]
贝蒂氏结晶样角膜视网膜 dystrophy 患者基因替代疗法的开放性、单组、探索性试验
Jinyuan Wang,Jinlu Zhang,Shicheng Yu et al.
Jinyuan Wang et al.
Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2, which results in blindness in the working-age population, and there is currently no available treatment. Here, we report the results o...
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors [0.03%]
SRY-box转录因子9通过直接相互作用在肿瘤中触发YAP核进入
Hui Qian,Chen-Hong Ding,Fang Liu et al.
Hui Qian et al.
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YAP are not fully understood. In ...
PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis [0.03%]
PBX/knotted 1同系物-homeobox-2(PKNOX2)是心肌纤维化的新调节因子
Liang Chen,Haotong Li,Xiaorui Liu et al.
Liang Chen et al.
Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically described because of the limitations i...
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma [0.03%]
一种新型工程IL-21受体使T细胞受体工程T细胞武装以对抗肝细胞癌
Wei Zhu,Zhiming Zhang,Jinzhang Chen et al.
Wei Zhu et al.
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γc) family cytokines such as IL-2, IL-7, IL-15 and IL-21 play fundamental role...
Ying Xia,Ming Sun,Hai Huang et al.
Ying Xia et al.
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug th...
The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial [0.03%]
一项单臂II期临床试验：PD-1抑制在高危肺磨玻璃结节病灶活性及免疫动态中的作用与机制探索
Bo Cheng,Caichen Li,Jianfu Li et al.
Bo Cheng et al.
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage ground-glass opacity (GGO) lesions ...
METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression [0.03%]
METTL14下调通过MyD88/NF-κB途径驱动S100A4+单核细胞来源的巨噬细胞促进MAFLD进展
Yue-Fan Wang,Wen-Li Zhang,Zhi-Xuan Li et al.
Yue-Fan Wang et al.
Without intervention, a considerable proportion of patients with metabolism-associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism-associated steatohepatitis (MASH), liver fibrosis, and even hepatocellular ...
Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma [0.03%]
新型PI3Kα/δ口服抑制剂TQB3525治疗复发/难治性滤泡淋巴瘤的II期研究
Huaqing Wang,Jifeng Feng,Yanyan Liu et al.
Huaqing Wang et al.
This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (ClinicalTrials.gov NCT04324879. ...
Ninel Azoitei,Sandra Heller,Alexander Kleger
Ninel Azoitei