Two hits are better than one: rational dual strategy efficiently fights neuroblastoma [0.03%]
一石二鸟：理性双重策略有效对抗神经母细胞瘤
Jacques Zimmer,Camille Rolin,Markus Ollert
Jacques Zimmer
Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications [0.03%]
METTL14在代谢紊乱相关性脂肪肝病中作用的解析：见解与治疗启示
So Jung Kim,Jeongeun Hyun
So Jung Kim
A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology [0.03%]
异柠檬酸脱氢酶3β对数中基因6的正反馈抑制促进类似阿尔茨海默病的病理变化
Xin Wang,Qian Liu,Hai-Tao Yu et al.
Xin Wang et al.
Impaired brain glucose metabolism is an early indicator of Alzheimer's disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical tr...
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1 [0.03%]
含有鞭毛蛋白的三聚体RBD支架蛋白鼻粘膜免疫可诱导对包括JN.1变异株在内的多种SARS-CoV-2变异株的长期保护力
Xian Li,Mengxin Xu,Jingyi Yang et al.
Xian Li et al.
Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (...
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications [0.03%]
诱导多能干细胞(iPSCs)：诱导的分子机制及其应用
Jonas Cerneckis,Hongxia Cai,Yanhong Shi
Jonas Cerneckis
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, ...
Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment [0.03%]
用于CAR-T细胞的Cas13d介导基因敲低：迈向通用型癌症治疗疗法
Midori Johnston,Nadine Urban,Can Dincer
Midori Johnston
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets [0.03%]
胆酸代谢和信号转导的生理和病理机制及治疗靶点：分子机制及治疗靶点
Joshua S Fleishman,Sunil Kumar
Joshua S Fleishman
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro-inflammatory/anti-inflammatory balance. Bile acid metabolism and signali...
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity [0.03%]
黏附G蛋白偶联受体Latrophilin 1功能障碍增加肥胖发病风险
André Nguyen Dietzsch,Hadi Al-Hasani,Joachim Altschmied et al.
André Nguyen Dietzsch et al.
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological inte...
Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis [0.03%]
黏附G蛋白偶联受体(aGPCR)的模块化结构及其可变剪接调控神经突触形成的作用机制研究
Tobias Langenhan
Tobias Langenhan
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection [0.03%]
FGF7可增强人胰岛类器官中的ACE2表达从而加剧SARS-CoV-2感染
Hao Meng,Zhiying Liao,Yanting Ji et al.
Hao Meng et al.
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current stud...