Current advance of nanotechnology in diagnosis and treatment for malignant tumors [0.03%]
纳米技术在恶性肿瘤诊断和治疗中的最新进展
Bilan Wang,Shiqi Hu,Yan Teng et al.
Bilan Wang et al.
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engi...
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies [0.03%]
钾电压门控通道亚家族H成员2（KCNH2）是肠降糖素分泌促进疗法的一个颇有前景的作用靶点
Ying-Chao Yuan,Hao Wang,Ze-Ju Jiang et al.
Ying-Chao Yuan et al.
Derived from enteroendocrine cells (EECs), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are pivotal incretin hormones crucial for blood glucose regulation. Medications of GLP-1 analogs and GLP-1 recepto...
Mark Helm,Marie-Luise Winz
Mark Helm
Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis [0.03%]
乙硫氨酸-S-甲基转移酶1活化剂A通过激活betaine-homocysteine S-methyltransferase 1改善肝脂肪变性疾病
Han Yan,Wenjun Liu,Rui Xiang et al.
Han Yan et al.
Nonalcoholic fatty liver disease (NAFLD) is a serious threat to public health, but its underlying mechanism remains poorly understood. In screening important genes using Gene Importance Calculator (GIC) we developed previously, ribosomal mo...
Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles [0.03%]
单细胞全基因组测序揭示脑细胞特异的突变特征
Melania Capasso,N Ahmad Aziz
Melania Capasso
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling [0.03%]
LIM域独有4(LMO4)通过增强IL-21-STAT3信号促进CD8+T细胞的干性及肿瘤排斥作用
Roland C Schelker,Jessica Fioravanti,Fabio Mastrogiovanni et al.
Roland C Schelker et al.
High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regula...
Breaking barriers: noncanonical inflammasome executes blood-brain barrier disruption [0.03%]
突破屏障：非经典炎症小体执行血脑屏障破坏功能
Martin Dichgans,Jonas J Neher,Yaw Asare
Martin Dichgans
Jimeng Su,Ying Song,Zhipeng Zhu et al.
Jimeng Su et al.
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintena...
Hua Miao,Fei Liu,Yan-Ni Wang et al.
Hua Miao et al.
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants i...
Mengyuan He,Xiangxiang Zhou,Xin Wang
Mengyuan He
Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups, and has a profound effect on protein function. Glycosy...