Yue Zhou,Lei Tao,Jiahao Qiu et al.
Yue Zhou et al.
Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognos...
Xiang Wei,Fangfang Zhou,Long Zhang
Xiang Wei
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends togethe...
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study [0.03%]
斯鲁利单抗（PD-1抗体）联合希维普替尼（组蛋白脱乙酰酶抑制剂）治疗复发或难治性结外NK/T细胞淋巴瘤患者：Ib/II期临床研究(SCENT)
Yan Gao,Haixia He,Xueping Li et al.
Yan Gao et al.
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete response (CR) rate and the duration of response (DOR) need to be improved. This phase 1b/2...
Yao Zong,Hao Li,Peng Liao et al.
Yao Zong et al.
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in many common pathologies, includin...
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis [0.03%]
2-APQC通过调节线粒体稳态缓解心肌肥大和纤维化：一种激活Sirtuin-3(SIRT3)的small-molecule激活剂
Fu Peng,Minru Liao,Wenke Jin et al.
Fu Peng et al.
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently...
Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain [0.03%]
一种针对SARS-CoV-2刺突蛋白N端结构域保守表位的IgM样纳米抗体增强效力
Bo Liu,Honghui Liu,Pu Han et al.
Bo Liu et al.
Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such a...
Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study [0.03%]
新冠灭活疫苗和重组蛋白疫苗序贯接种在老年人群中的安全性、免疫原性和保护效力：前瞻性队列研究
Hong-Hong Liu,Yunbo Xie,Bao-Peng Yang et al.
Hong-Hong Liu et al.
The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 elderly and 73 young participants ...
Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT [0.03%]
TPR-CHAT对CRISPR-Cas7-11负调控的结构基础
Tian Hong,Qinghua Luo,Haiyun Ma et al.
Tian Hong et al.
CRISPR‒Cas7-11 is a Type III-E CRISPR-associated nuclease that functions as a potent RNA editing tool. Tetratrico-peptide repeat fused with Cas/HEF1-associated signal transducer (TPR-CHAT) acts as a regulatory protein that interacts with C...
SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation [0.03%]
SARS-CoV-2异常提高线粒体生物能以促进病毒的大量增殖
Hye Jin Shin,Wooseong Lee,Keun Bon Ku et al.
Hye Jin Shin et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 'highly transmissible respiratory pathogen, leading to severe multi-organ damage. However, knowledge regarding SARS-CoV-2-induced cellular alterations is limited. In this stu...