G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding [0.03%]
G蛋白介导的信号转导：GTP结合后的G蛋白激活分子事件
Evi Kostenis,Lars Jürgenliemke,Judith Alenfelder
Evi Kostenis
Hongxia Niu,Jiaying Gu,Ying Zhang
Hongxia Niu
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after stress removal...
Beilei Liu,Hongyu Zhou,Licheng Tan et al.
Beilei Liu et al.
Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive an...
Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology [0.03%]
correction：异柠檬酸脱氢酶3β对配对盒基因6的正反馈抑制促进阿尔茨海默病样病理的发展
Xin Wang,Qian Liu,Hai-Tao Yu et al.
Xin Wang et al.
The Ca2+-sensing receptor and the pocketome: comparing nature's complexity with human intervention in receptor modulation [0.03%]
钙感应受体与结合位点组学：比较自然的复杂性与人类在受体调节中的干预作用
Edda S F Matthees,Carsten Hoffmann
Edda S F Matthees
SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study [0.03%]
SHR-A1811（抗体药物偶联物）在HER2突变型晚期非小细胞肺癌患者中的Ib/II期临床试验
Ziming Li,Zhengbo Song,Wei Hong et al.
Ziming Li et al.
A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer (NSCLC). Here, we report r...
Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma [0.03%]
关于:MELK是一种促癌激酶 对肺癌的发生发展至关重要
Qin Tang,Wan Li,Xiangjin Zheng et al.
Qin Tang et al.
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases [0.03%]
抑制蛋白酶体和WEE家族激酶协同诱导有丝分裂焦亡和抗肿瘤效应
Zhan-Li Chen,Chen Xie,Wei Zeng et al.
Zhan-Li Chen et al.
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasome-mediated protein degradation ...
Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy [0.03%]
prosaposin岩藻糖基化：一种新的肿瘤免疫逃逸机制及其对癌症免疫治疗的启示
Matthias Peipp,Diana Dudziak,Christian Kellner
Matthias Peipp
Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway [0.03%]
人工智能邂逅身体意识：任务驱动型神经网络揭示本体感觉通路的计算原理
Leonard E van Dyck,Frank Bremmer,Katharina Dobs
Leonard E van Dyck