Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders [0.03%]
自身免疫机制的进化及自身免疫病治疗新策略
Yi Song,Jian Li,Yuzhang Wu
Yi Song
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's own components, resulting in tissue destruction and organ dysfunction. Autoimmune diseases affect a wide range of people in many parts of the worl...
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study [0.03%]
用于下腔静脉肿瘤血栓的透明细胞肾癌的新辅助特瑞普利单抗联合阿昔替尼方案：NEOTAX II期临床试验
Liangyou Gu,Cheng Peng,Qiyang Liang et al.
Liangyou Gu et al.
The potential benefit of neoadjuvant toripalimab plus axitinib in cases with clear cell renal cell carcinoma (ccRCC) and inferior vena cava tumor thrombus (IVC-TT) remains unclear. NEOTAX was a phase 2 study to investigate the efficacy and ...
Xi Lu,Qingxing Xie,Xiaohui Pan et al.
Xi Lu et al.
Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance (IR) and it is one component of metabolic syndrome (MS), and ...
Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas [0.03%]
表皮生长因子受体突变型肺腺癌小细胞转化的机制探索和模型建立
Yan Li,Tongji Xie,Shouzheng Wang et al.
Yan Li et al.
Small-cell lung cancer (SCLC) transformation accounts for 3-14% of resistance in EGFR-TKI relapsed lung adenocarcinomas (LUADs), with unknown molecular mechanisms and optimal treatment strategies. We performed transcriptomic analyses (inclu...
Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death [0.03%]
内源免疫对危险信号的感知：血红素复合物介导的细胞溶解死亡的新机制
Chintan Chhatbar,Michael Schulz,Roman Sankowski
Chintan Chhatbar
Advancing clinical-basic-clinical research: exploring novel immunotargets for ovarian cancer [0.03%]
临床-基础-临床研究的推进：探索卵巢癌免疫治疗新靶点
Yuanzhuo Gu,Long Zhang,Weiguo Lv
Yuanzhuo Gu
Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p [0.03%]
组蛋白去乙酰化抑制通过肌肉来源的外泌体中mir-873-3p促进成骨分化
Ming Chen,Yi Li,Mingming Zhang et al.
Ming Chen et al.
Regular physical activity is widely recognized for reducing the risk of various disorders, with skeletal muscles playing a key role by releasing biomolecules that benefit multiple organs and tissues. However, many individuals, particularly ...
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity [0.03%]
表观遗传阅读蛋白ZMYND11通过非典行功能限制HNRNPA1介导的应激颗粒形成及致癌作用
Cheng Lian,Chunyi Zhang,Pan Tian et al.
Cheng Lian et al.
Epigenetic readers frequently affect gene regulation, correlate with disease prognosis, and hold significant potential as therapeutic targets for cancer. Zinc finger MYND-type containing 11 (ZMYND11) is notably recognized for reading the ep...
Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system [0.03%]
棕榈酰化通过调节ZDHHC3-Cadm4轴调控中枢神经系统的髓鞘形成
Yanli Chang,Jiangli Zhu,Xiaopeng Li et al.
Yanli Chang et al.
The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 ...
A systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver [0.03%]
系统研究胰腺癌病人：通过研究肝脏预测转移现象
Susanne Roth,Christoph Michalski,Jörg D Hoheisel
Susanne Roth