Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis [0.03%]
乙硫氨酸-S-甲基转移酶1活化剂A通过激活betaine-homocysteine S-methyltransferase 1改善肝脂肪变性疾病
Han Yan,Wenjun Liu,Rui Xiang et al.
Han Yan et al.
Nonalcoholic fatty liver disease (NAFLD) is a serious threat to public health, but its underlying mechanism remains poorly understood. In screening important genes using Gene Importance Calculator (GIC) we developed previously, ribosomal mo...
Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles [0.03%]
单细胞全基因组测序揭示脑细胞特异的突变特征
Melania Capasso,N Ahmad Aziz
Melania Capasso
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling [0.03%]
LIM域独有4(LMO4)通过增强IL-21-STAT3信号促进CD8+T细胞的干性及肿瘤排斥作用
Roland C Schelker,Jessica Fioravanti,Fabio Mastrogiovanni et al.
Roland C Schelker et al.
High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regula...
Breaking barriers: noncanonical inflammasome executes blood-brain barrier disruption [0.03%]
突破屏障：非经典炎症小体执行血脑屏障破坏功能
Martin Dichgans,Jonas J Neher,Yaw Asare
Martin Dichgans
Jimeng Su,Ying Song,Zhipeng Zhu et al.
Jimeng Su et al.
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintena...
Hua Miao,Fei Liu,Yan-Ni Wang et al.
Hua Miao et al.
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants i...
Mengyuan He,Xiangxiang Zhou,Xin Wang
Mengyuan He
Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups, and has a profound effect on protein function. Glycosy...
Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression [0.03%]
揭示抑制性免疫微环境在心脏黏液瘤进展中的关键作用
Zedong Jiang,Qianlong Kang,Hong Qian et al.
Zedong Jiang et al.
Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition of this condition is still not well understood. To fill this gap, we analyzed 75,641 cells from...
Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives [0.03%]
肿瘤转移的机制见解和治疗干预：最新进展及展望
Xiaoli Shi,Xinyi Wang,Wentao Yao et al.
Xiaoli Shi et al.
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain...
Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system [0.03%]
小胶质细胞复合物I活性：中枢神经系统阴燃性炎症的关键因素
Jana K Sonner,Christina Mayer,Manuel A Friese
Jana K Sonner