Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis [0.03%]
心脏特异性ADAM17敲除通过抑制TNFα-TRAF3-TAK1-MAPK轴缓解阿霉素诱导的心肌病
Lin Xie,Fei Xue,Cheng Cheng et al.
Lin Xie et al.
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 may ameliorate doxorubi...
Therapeutic interfering particles against HIV: molecular parasites reducing viremia [0.03%]
用于治疗HIV的干扰粒子：减少病毒血症的分子寄生虫
Henning Gruell,Stanley Odidika,Philipp Schommers
Henning Gruell
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy [0.03%]
用于胰腺癌协同治疗的加载适配体-药物缀合物的细菌
Yu Xiao,Tao Pan,Wuren Da et al.
Yu Xiao et al.
Pancreatic cancer is one of the most malignant tumors with the highest mortality rates, and it currently lacks effective drugs. Aptamer-drug conjugates (ApDC), as a form of nucleic acid drug, show great potential in cancer therapy. However,...
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects [0.03%]
铁代谢和铁死亡在人类疾病中的作用：机制与治疗前景
Qin Ru,Yusheng Li,Lin Chen et al.
Qin Ru et al.
Iron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial for overall health. Both iron overload and deficiency can cause various disorders and human diseases...
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study [0.03%]
贝美纳联合安罗替尼治疗EGFR突变阳性晚期非小细胞肺癌耐药患者：Ⅰ/Ⅱ期临床试验
Meiqi Shi,Ping Chen,Bin Cui et al.
Meiqi Shi et al.
The effect of immune-based therapies on patients with epidermal growth factor receptor (EGFR)-positive advanced non-small cell lung cancer (NSCLC) resistant to EGFR tyrosine kinase inhibitor (TKI) therapy remains unclear. The ALTER-L038 stu...
Zaoqu Liu,Jingqi Chen,Yuqing Ren et al.
Zaoqu Liu et al.
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at numerous phases of the disease and progress under intense evolutionary pressures. Organ-specific metastasis relies on the formation of pre-metastat...
Late onset Alzheimer's disease: modeling disease hallmarks via in vitro 3D iNeuron cultures [0.03%]
晚发性阿尔茨海默病的研究：通过体外3D诱导神经元模型模拟疾病特征
Giacomo Masserdotti
Giacomo Masserdotti
The multiple roles of interferon regulatory factor family in health and disease [0.03%]
干扰素调节因子家族在健康和疾病中的多种作用
Lian Wang,Yanghui Zhu,Nan Zhang et al.
Lian Wang et al.
Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF membe...
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation [0.03%]
AXIN1通过IRF3稳定和诱导相分离增强抗病毒反应
Dan-Ling Dai,Chu Xie,Lan-Yi Zhong et al.
Dan-Ling Dai et al.
Axis inhibition protein 1 (AXIN1), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we id...