Dharmendra Kumar,Iqbal Hyder,Wilfried A Kues
Dharmendra Kumar
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB [0.03%]
通过下调c-Fos和JunB防止CAR-T细胞耗竭和分化以抑制MEK信号转导
Xiujian Wang,Xiao Tao,Pengjie Chen et al.
Xiujian Wang et al.
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer tr...
Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial [0.03%]
鲁索利替尼联合类固醇治疗急性移植物抗宿主病的多中心随机三期临床试验
Liping Dou,Yanli Zhao,Jingjing Yang et al.
Liping Dou et al.
Newly diagnosed patients with high-risk acute graft-versus-host disease (aGVHD) often experience poor clinical outcomes and low complete remission rates. Ruxolitinib with corticosteroids showed promising efficacy in improving response and f...
Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials [0.03%]
系统纵向免疫特征分析识别出增殖性Treg细胞可作为免疫疗法获益的预测生物标志物：来自III期CONTINUUM和DIPPER试验的生物标志物分析结果
Sai-Wei Huang,Wei Jiang,Sha Xu et al.
Sai-Wei Huang et al.
The identification of predictors for immunotherapy is often hampered by the absence of control groups in many studies, making it difficult to distinguish between prognostic and predictive biomarkers. This study presents biomarker analyses f...
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis [0.03%]
芽胞白喉杆菌分泌一种新型糖脂以促进肉芽肿小叶乳腺炎的发展
Ran Liu,Zixuan Luo,Chong Dai et al.
Ran Liu et al.
Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence, the incidence rate has gradually increased, and has become a se...
Maike Hofmann,Robert Thimme,Wolfgang W Schamel
Maike Hofmann
Bo Wu,Bo Zhang,Bowen Li et al.
Bo Wu et al.
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which has shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment ...
Correction: The JAK-STAT pathway: from structural biology to cytokine engineering [0.03%]
关于jak-stat通路的更正：从结构生物学至细胞因子工程学
You Lv,Jianxun Qi,Jeffrey J Babon et al.
You Lv et al.
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy [0.03%]
用于结直肠癌治疗的序列响应型纳米 PROTACs 的精准胞内递送及降解效率增强
Liuqing Yang,Ye Yang,Jing Zhang et al.
Liuqing Yang et al.
PROteolysis TArgeting Chimeras (PROTACs) have been considered the next blockbuster therapies. However, due to their inherent limitations, the efficacy of PROTACs is frequently impaired by limited tissue penetration and particularly insuffic...
Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities [0.03%]
整合求破局：泛癌种蛋白质基因组学发现癌症的脆弱性与治疗新机遇
Debomita Chakraborty,Rossana Romero,Krishnaraj Rajalingam
Debomita Chakraborty