Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances [0.03%]
三级淋巴器官在疾病中的作用：免疫机制和治疗进展
Lianyu Zhao,Song Jin,Shengyao Wang et al.
Lianyu Zhao et al.
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs (SLOs), the formation of TLSs relies on the interaction between ly...
Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope [0.03%]
通过一种高度保守的SARS-CoV-2 NTD表位增强RBD反应性和S1脱落性
Qianhui Zhu,Pan Liu,Shuo Liu et al.
Qianhui Zhu et al.
Hyperuricemia and its related diseases: mechanisms and advances in therapy [0.03%]
高尿酸血症及其相关疾病：机制与治疗进展
Lin Du,Yao Zong,Haorui Li et al.
Lin Du et al.
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc. Significantly impairing the qual...
Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data [0.03%]
基于多模态数据预测胃癌对抗HER2治疗或抗HER2联合免疫治疗的反应
Zifan Chen,Yang Chen,Yu Sun et al.
Zifan Chen et al.
The sole use of single modality data often fails to capture the complex heterogeneity among patients, including the variability in resistance to anti-HER2 therapy and outcomes of combined treatment regimens, for the treatment of HER2-positi...
An emerging artificial nanomachine: a nanoengine with a reversible clutch [0.03%]
一种新兴的人工纳米机器：可逆离合器纳米发动机
Ziqi Fang,Jianxin Jiang,Min Wu
Ziqi Fang
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies [0.03%]
阿尔茨海默病的研究新进展：发病机制、临床试验和新药开发策略
Jifa Zhang,Yinglu Zhang,Jiaxing Wang et al.
Jifa Zhang et al.
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate and diverse, stemming from a combination of factors such as aging, genetics, and environ...
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity [0.03%]
annexin a1通过结合pdz和lim域7来抑制脂肪细胞生成并预防肥胖
Lu Fang,Changjie Liu,Zong-Zhe Jiang et al.
Lu Fang et al.
Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis. Annexin A1 (ANXA1) is known to inhibit phospholipase A2, exhibiting anti-infl...
The JAK-STAT pathway: from structural biology to cytokine engineering [0.03%]
结构生物学与细胞因子工程中的JAK-STAT途径研究进展
You Lv,Jianxun Qi,Jeffrey J Babon et al.
You Lv et al.
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as...
MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer [0.03%]
MYC和KRAS的协同作用：从癌症研究中的历史难题到治疗机遇
Sílvia Casacuberta-Serra,Íñigo González-Larreategui,Daniel Capitán-Leo et al.
Sílvia Casacuberta-Serra et al.
RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS being the most frequently mutated and MYC the most amplified. The cooperative interplay between RAS and MYC constitutes a complex and multifaceted phenomenon, ...
Immune recall enhances cross-reactive antibody longevity after a large wave of SARS-CoV-2 breakthrough infection [0.03%]
免疫回忆增强突破感染后SARS-CoV-2交叉反应抗体的持久性
Dan Li,Qingfei Chu,Kang Li et al.
Dan Li et al.