Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications [0.03%]
基于mRNA药物的临床前研究和临床应用进展与前景分析
Yingying Shi,Meixing Shi,Yi Wang et al.
Yingying Shi et al.
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge in interest can be largely attributed to the demonstration of distinct advantage...
Ram Abou Zaki,Assam El-Osta
Ram Abou Zaki
Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial [0.03%]
载药微球经导管动脉化疗栓塞联合阿帕替尼对比单用载药微球经导管动脉化疗栓塞治疗不可手术切除的肝细胞癌的随机、前瞻性、多中心Ⅲ期临床试验
Xuhua Duan,Hao Li,Donglin Kuang et al.
Xuhua Duan et al.
This randomized, prospective, multicenter (12 centers in China) phase III trial (Chinese Clinical Trial Registry #ChiCTR2000041170) compared drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with apatinib and DEB-TACE mo...
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism [0.03%]
禁食后过度进食可诱导肠道类器官干细胞增殖及基因突变从而促肠癌发生发展：多胺代谢的潜在作用机制研究
Sarah Brunner,Klaus-Peter Janssen,Josef Ecker
Sarah Brunner
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway [0.03%]
STX11过表达通过抑制PI3K/AKT/mTOR途径的成纤维细胞活化来缓解肺纤维化
Guichuan Huang,Xiangsheng Yang,Qingyang Yu et al.
Guichuan Huang et al.
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease. However, the underlying mechanism of fibroblast activation...
Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B [0.03%]
用于慢性乙型肝炎的治疗性疫苗：脂质纳米颗粒中的多重RNA疗法
Hari Krishnareddy Rachamala,Srujan Marepally
Hari Krishnareddy Rachamala
First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study [0.03%]
贝美前列素联合安罗替尼和化疗一线治疗晚期或转移/复发性食管鳞癌：一项多中心II期研究
Ning Li,Jin Xia,Xiaohui Gao et al.
Ning Li et al.
Although first-line immunochemotherapy has improved prognosis for patients with advanced esophageal squamous cell carcinoma (ESCC), more effective strategies still require further investigation. This multi-center, phase II study (ClinicalTr...
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control [0.03%]
早期间歇性胆固醇暴露加速动脉粥样硬化：一个振荡放大器呼唤主动控制
Maria Kral,Yvonne Döring,Christian Weber
Maria Kral
Mef2d: a novel transcription factor in type 2 allergic lung inflammation [0.03%]
Mef2d：一种新型2型过敏性肺炎症转录因子
Laura Surace,Christoph Wilhelm,Christian Bode
Laura Surace
Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming [0.03%]
间歇性高脂饮食通过重编程中性粒细胞促进动脉粥样硬化进展
Andrea Herrero-Cervera,Raphael Chevre,Oliver Soehnlein
Andrea Herrero-Cervera