Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2 [0.03%]
表征ACTN4作为针对SARS-CoV-2的新型抗病毒靶点
Miao Zhu,Fang Huang,Huize Sun et al.
Miao Zhu et al.
The various mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose a substantial challenge in mitigating the viral infectivity. The identification of novel host factors influencing SARS-CoV-2 replication holds potent...
Zhikai Zheng,Yao Zong,Yiyang Ma et al.
Zhikai Zheng et al.
The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body. This receptor specifical...
Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial [0.03%]
斯鲁利单抗联合安罗替尼和化疗用于广泛期小细胞肺癌二线及以上治疗的II期临床试验
Xiao Han,Jun Guo,Lingyu Li et al.
Xiao Han et al.
Treatment options for patients with relapsed extensive-stage small cell lung cancer (ES-SCLC) remain scarce. This study aims to evaluate the efficacy and safety of combining anlotinib and sintilimab plus chemotherapy as a second line or lat...
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases [0.03%]
表观遗传新视野：组蛋白修饰与疾病的新联系
Weiyi Yao,Xinting Hu,Xin Wang
Weiyi Yao
Histone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases and their potential as ta...
Type 2 diabetes across populations of different ancestry: deconstructing the genomic landscape [0.03%]
不同祖先人群中2型糖尿病的遗传结构差异：解读基因组景观
Georgia Xourafa,Christian Herder,Michael Roden
Georgia Xourafa
Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges [0.03%]
转化挑战中的间充质干细胞的药代动力学特征
Yunlong Shan,Mengying Zhang,Enxiang Tao et al.
Yunlong Shan et al.
Over the past two decades, mesenchymal stem/stromal cell (MSC) therapy has made substantial strides, transitioning from experimental clinical applications to commercial products. MSC therapies hold considerable promise for treating refracto...
One step at a time: new insights into double-stranded ribonucleic acid virus assembly [0.03%]
一步一个脚印：双链RNA病毒装配新见解
Virgile Rat,Alexander Borodavka,Don C Lamb
Virgile Rat
Correction: M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity [0.03%]
纠正：M2巨噬细胞通过上调PI3K-AKT途径活性支持巨核系生成，而非M1巨噬细胞
Hong-Yan Zhao,Yuan-Yuan Zhang,Tong Xing et al.
Hong-Yan Zhao et al.
Sex difference in human diseases: mechanistic insights and clinical implications [0.03%]
人类疾病的性别差异：机制和临床意义的见解
Yuncong Shi,Jianshuai Ma,Sijin Li et al.
Yuncong Shi et al.
Sex characteristics exhibit significant disparities in various human diseases, including prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Risk profiles and pathological ma...
Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control [0.03%]
新兴和再现的传染病：全球趋势及其预防控制新策略
Shen Wang,Wujian Li,Zhenshan Wang et al.
Shen Wang et al.
To adequately prepare for potential hazards caused by emerging and reemerging infectious diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future outbreaks and for which research and development (R&D) e...