Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics [0.03%]
饮食限制干预：寿命的获益需要抵抗力且受到免疫功能下降和遗传性的限制
Yulin Chen,Anjalika Malik,Karl Lenhard Rudolph
Yulin Chen
Human olfaction: odour coding and cross-modal concept representation in single olfactory cortex neurons [0.03%]
人类嗅觉：嗅觉皮层单个神经元中的气味编码及跨模式概念表达
Antonia Beiersdorfer,Markus Rothermel,Christian Lohr
Antonia Beiersdorfer
Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis [0.03%]
解开RNA密码：一种尿嘧啶RNA修饰驱动糖基RNA生物生成
Marco Sachse,Konstantinos Stellos
Marco Sachse
Zitong C,Zhenyu C,Y Rinkevich
Zitong C
Wanlin Dai,Xinbo Qiao,Yuanyuan Fang et al.
Wanlin Dai et al.
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzyme...
Ischemic stroke is an instigator of cardiac dysfunction: the interleukin-1β pathway [0.03%]
缺血性卒中是心功能不全的诱发因素：IL-1β信号通路的作用
Renate Schoenenberger-Berzins,Andreas Janis Schoenenberger,Franz H Messerli
Renate Schoenenberger-Berzins
TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy [0.03%]
用于癌症治疗的靶向蛋白降解的新型杂二特异性抗体TransTACs
Wolfgang Walther,Sebastian Torke,Ulrike Stein
Wolfgang Walther
Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial [0.03%]
特瑞普利单抗联合化疗治疗局部晚期或转移性胰腺导管腺癌的免疫细胞空间互作潜在预测标志：Ib/II期临床试验
Ke Cheng,Xiaoying Li,Wanrui Lv et al.
Ke Cheng et al.
Advanced pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Immunotherapy alone offers limited efficacy, but it is still unknown whether its combination with chemotherapy could offer synergistic anti-tumor effects. This phase I...
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors [0.03%]
利用细菌重塑肿瘤微环境可增强T细胞治疗晚期实体瘤的效果
Chaojie Zhu,Chao Liu,Qing Wu et al.
Chaojie Zhu et al.
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells. Here, we develo...