Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects [0.03%]
铁代谢和铁死亡在人类疾病中的作用：机制与治疗前景
Qin Ru,Yusheng Li,Lin Chen et al.
Qin Ru et al.
Iron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial for overall health. Both iron overload and deficiency can cause various disorders and human diseases...
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study [0.03%]
贝美纳联合安罗替尼治疗EGFR突变阳性晚期非小细胞肺癌耐药患者：Ⅰ/Ⅱ期临床试验
Meiqi Shi,Ping Chen,Bin Cui et al.
Meiqi Shi et al.
The effect of immune-based therapies on patients with epidermal growth factor receptor (EGFR)-positive advanced non-small cell lung cancer (NSCLC) resistant to EGFR tyrosine kinase inhibitor (TKI) therapy remains unclear. The ALTER-L038 stu...
Zaoqu Liu,Jingqi Chen,Yuqing Ren et al.
Zaoqu Liu et al.
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at numerous phases of the disease and progress under intense evolutionary pressures. Organ-specific metastasis relies on the formation of pre-metastat...
Late onset Alzheimer's disease: modeling disease hallmarks via in vitro 3D iNeuron cultures [0.03%]
晚发性阿尔茨海默病的研究：通过体外3D诱导神经元模型模拟疾病特征
Giacomo Masserdotti
Giacomo Masserdotti
The multiple roles of interferon regulatory factor family in health and disease [0.03%]
干扰素调节因子家族在健康和疾病中的多种作用
Lian Wang,Yanghui Zhu,Nan Zhang et al.
Lian Wang et al.
Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF membe...
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation [0.03%]
AXIN1通过IRF3稳定和诱导相分离增强抗病毒反应
Dan-Ling Dai,Chu Xie,Lan-Yi Zhong et al.
Dan-Ling Dai et al.
Axis inhibition protein 1 (AXIN1), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we id...
Envafolimab plus lenvatinib and transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a prospective, single-arm, phase II study [0.03%]
envafolimab联合仑伐替尼和TACE治疗不可切除的肝细胞癌患者：一项前瞻性单臂二期临床试验
Yiwen Chen,Junlei Zhang,Wendi Hu et al.
Yiwen Chen et al.
Evidences regarding the feasibility of transcatheter arterial chemoembolization (TACE)-based therapy for unresectable hepatocellular carcinoma (uHCC) remains limited. This study aimed to investigate the efficacy and safety of TACE combined ...
Metabolic regulation of the immune system in health and diseases: mechanisms and interventions [0.03%]
代谢调节免疫系统在健康和疾病中的作用：机制与干预措施
Tengyue Hu,Chang-Hai Liu,Min Lei et al.
Tengyue Hu et al.
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathoge...
Discovery of biosynthetic enzymes for β-D-manno-heptoses across kingdoms: novel agonists for ALPK1/NF-κB-dependent immune response [0.03%]
跨物种发现β-D-甘露庚糖生物合成酶：一种ALPK1/NF-κB依赖型免疫反应激动剂
Gunter Maubach,Michelle C C Lim,Michael Naumann
Gunter Maubach