Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism [0.03%]
禁食后过度进食可诱导肠道类器官干细胞增殖及基因突变从而促肠癌发生发展：多胺代谢的潜在作用机制研究
Sarah Brunner,Klaus-Peter Janssen,Josef Ecker
Sarah Brunner
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway [0.03%]
STX11过表达通过抑制PI3K/AKT/mTOR途径的成纤维细胞活化来缓解肺纤维化
Guichuan Huang,Xiangsheng Yang,Qingyang Yu et al.
Guichuan Huang et al.
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease. However, the underlying mechanism of fibroblast activation...
Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B [0.03%]
用于慢性乙型肝炎的治疗性疫苗：脂质纳米颗粒中的多重RNA疗法
Hari Krishnareddy Rachamala,Srujan Marepally
Hari Krishnareddy Rachamala
First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study [0.03%]
贝美前列素联合安罗替尼和化疗一线治疗晚期或转移/复发性食管鳞癌：一项多中心II期研究
Ning Li,Jin Xia,Xiaohui Gao et al.
Ning Li et al.
Although first-line immunochemotherapy has improved prognosis for patients with advanced esophageal squamous cell carcinoma (ESCC), more effective strategies still require further investigation. This multi-center, phase II study (ClinicalTr...
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control [0.03%]
早期间歇性胆固醇暴露加速动脉粥样硬化：一个振荡放大器呼唤主动控制
Maria Kral,Yvonne Döring,Christian Weber
Maria Kral
Mef2d: a novel transcription factor in type 2 allergic lung inflammation [0.03%]
Mef2d：一种新型2型过敏性肺炎症转录因子
Laura Surace,Christoph Wilhelm,Christian Bode
Laura Surace
Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming [0.03%]
间歇性高脂饮食通过重编程中性粒细胞促进动脉粥样硬化进展
Andrea Herrero-Cervera,Raphael Chevre,Oliver Soehnlein
Andrea Herrero-Cervera
Juergen Dukart,Leon D Lotter,Simon B Eickhoff
Juergen Dukart
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization [0.03%]
天然杀伤细胞功能、信号传导、分子机制及临床应用的全面概览
Sumei Chen,Haitao Zhu,Youssef Jounaidi
Sumei Chen
Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in cancer, viral infections, autoimmunity, pregnancy, w...
A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2 [0.03%]
具有免疫逃逸突变的RBD蛋白疫苗对SARS-CoV-2广谱保护性研究
Ran An,Hao Yang,Cong Tang et al.
Ran An et al.
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. There is an urgent need for the development of vaccines with bro...