Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants [0.03%]
鼻内递送亚单位蛋白疫苗可提供针对JN.1和XBB谱系变异株的保护免疫
Hong Lei,Weiqi Hong,Jingyun Yang et al.
Hong Lei et al.
The mucosal immune response plays a crucial role in the prevention of respiratory viruses. Given the risk of recurrent SARS-CoV-2 infections in the population, the rapid development of next-generation intranasal COVID-19 vaccines with high ...
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis [0.03%]
狼疮性肾炎中CXCL10-CXCR3轴募集的间充质干细胞介导的肾脏重塑及随后的IL4I1分泌
Qixiang Zhang,Yunlong Shan,Luping Shen et al.
Qixiang Zhang et al.
Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown potential as a therapeutic option for lupus nephritis (LN), particularly in patients refractory to conventional treatments. Despite extensive translational research on MSCs, ...
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation [0.03%]
EphrinB2介导的CDK5/ISL1通路通过解决心梗后的炎症促进心脏淋巴管生成并缓解缺血损伤
Yingnan Bai,Liming Chen,Fanghao Guo et al.
Yingnan Bai et al.
EphrinB2 (erythropoietin-producing hepatoma interactor B2) is a key Eph/ephrin family member, promoting angiogenesis, vasculogenesis, and lymphangiogenesis during embryonic development. However, the role of EphrinB2 in cardiac lymphangiogen...
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications [0.03%]
无膜细胞器的生理和病理功能及其分子基础
Yangxin Li,Yuzhe Liu,Xi-Yong Yu et al.
Yangxin Li et al.
Once considered unconventional cellular structures, membraneless organelles (MLOs), cellular substructures involved in biological processes or pathways under physiological conditions, have emerged as central players in cellular dynamics and...
Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies [0.03%]
识别帕金森病临床亚型的遗传靶点以优化药理治疗策略
Dewen Kong,Cao Li,LingYan Ma et al.
Dewen Kong et al.
The heterogeneity of Parkinson's disease (PD) has been recognized in clinical, with patients categorized into distinct subsets based on motor phenotype, such as tremor-dominant PD (TD), postural instability and gait difficulty-dominant PD (...
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus [0.03%]
人源化单克隆抗体2D4通过作用于CD132有望治疗系统性红斑狼疮
Huiqi Yin,Liming Li,Xiwei Feng et al.
Huiqi Yin et al.
Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness. To address this limitation, our focus was on CD132, a subunit common to six inflammatory factor receptors implica...
Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications [0.03%]
基于mRNA药物的临床前研究和临床应用进展与前景分析
Yingying Shi,Meixing Shi,Yi Wang et al.
Yingying Shi et al.
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge in interest can be largely attributed to the demonstration of distinct advantage...
Ram Abou Zaki,Assam El-Osta
Ram Abou Zaki
Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial [0.03%]
载药微球经导管动脉化疗栓塞联合阿帕替尼对比单用载药微球经导管动脉化疗栓塞治疗不可手术切除的肝细胞癌的随机、前瞻性、多中心Ⅲ期临床试验
Xuhua Duan,Hao Li,Donglin Kuang et al.
Xuhua Duan et al.
This randomized, prospective, multicenter (12 centers in China) phase III trial (Chinese Clinical Trial Registry #ChiCTR2000041170) compared drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with apatinib and DEB-TACE mo...