Zitong C,Zhenyu C,Y Rinkevich
Zitong C
Wanlin Dai,Xinbo Qiao,Yuanyuan Fang et al.
Wanlin Dai et al.
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzyme...
Ischemic stroke is an instigator of cardiac dysfunction: the interleukin-1β pathway [0.03%]
缺血性卒中是心功能不全的诱发因素：IL-1β信号通路的作用
Renate Schoenenberger-Berzins,Andreas Janis Schoenenberger,Franz H Messerli
Renate Schoenenberger-Berzins
TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy [0.03%]
用于癌症治疗的靶向蛋白降解的新型杂二特异性抗体TransTACs
Wolfgang Walther,Sebastian Torke,Ulrike Stein
Wolfgang Walther
Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial [0.03%]
特瑞普利单抗联合化疗治疗局部晚期或转移性胰腺导管腺癌的免疫细胞空间互作潜在预测标志：Ib/II期临床试验
Ke Cheng,Xiaoying Li,Wanrui Lv et al.
Ke Cheng et al.
Advanced pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Immunotherapy alone offers limited efficacy, but it is still unknown whether its combination with chemotherapy could offer synergistic anti-tumor effects. This phase I...
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors [0.03%]
利用细菌重塑肿瘤微环境可增强T细胞治疗晚期实体瘤的效果
Chaojie Zhu,Chao Liu,Qing Wu et al.
Chaojie Zhu et al.
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells. Here, we develo...
Neoadjuvant oncolytic virus orienx010 and toripalimab in resectable acral melanoma: a phase Ib trial [0.03%]
肢端黑色素瘤新辅助溶瘤病毒ORICX010和特瑞普利单抗治疗方案Ⅰb期临床研究
Jiayong Liu,Xuan Wang,Zhongwu Li et al.
Jiayong Liu et al.
Neoadjuvant PD-1 inhibitor is promising in cutaneous melanoma but remains unknown in acral melanoma (AM). This phase Ib trial study (Clinicaltrials.gov NCT04197882) assessed the efficacy and safety of the combination of neoadjuvant oncolyti...
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates [0.03%]
新一代猴痘疫苗：与改良型安卡拉痘苗相比，mRNA-1769疫苗在非人灵长类动物身上的效力研究
Leonie Mayer,Leonie M Weskamm,Marylyn M Addo
Leonie Mayer
A comprehensive proteomic analysis of umbilical cord blood supports COVID-19 vaccination before pregnancy [0.03%]
对脐带血的全面蛋白质组分析支持在怀孕前接种COVID-19疫苗
Jianbin Guo,Xiaoyue Tang,Roujie Huang et al.
Jianbin Guo et al.