Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression [0.03%]
脑内助纣为虐：小胶质细胞介导的髓鞘回收促进多形性胶质母细胞瘤进展中的细胞状态特异性进程
Antonio C Pagano Zottola,Thomas Daubon,Varun Venkataramani
Antonio C Pagano Zottola
Efficacy and safety of minocycline in retinitis pigmentosa: a prospective, open-label, single-arm trial [0.03%]
米诺环素治疗视网膜色素变性的疗效和安全性：一项前瞻性、开放标记、单臂临床试验
Yuxi Chen,Yuan Pan,Yanyan Xie et al.
Yuxi Chen et al.
Retinitis pigmentosa (RP) is characterized by progressive photoreceptor cells death accelerated by the proliferation and activation of microglia pathologically. No consensus exists on the treatment. Minocycline is recognized as a microglia ...
Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application [0.03%]
染色质可及性：生物学功能、分子机制及其治疗应用
Yang Chen,Rui Liang,Yong Li et al.
Yang Chen et al.
The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access restricted. The remain...
Liquid biopsy in cancer current: status, challenges and future prospects [0.03%]
循环肿瘤细胞和ctDNA液体活检的现状、挑战及未来前景
Liwei Ma,Huiling Guo,Yunxiang Zhao et al.
Liwei Ma et al.
Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold standard for tumor diagnosis due to its high level of laboratory standardization, good consistency of results, relatively stable samples, and high accurac...
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1 [0.03%]
磷酸化决定视黄酸诱导孤儿核受体SIX1介导的糖酵解代谢重编程及肿瘤促进作用
Yanni Lin,Ling Li,Bin Yuan et al.
Yanni Lin et al.
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors, protein kinases and transcription factors. However, it remains poorly understood how these components interact to regulate aerobic glycolysis coordinately. Here,...
BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling [0.03%]
BRAF抑制剂通过激活MAPK信号级联增强红细胞生成并治疗贫血症
Shunkang Wu,Yuelin Deng,Haobo Sun et al.
Shunkang Wu et al.
Erythropoiesis is a crucial process in hematopoiesis, yet it remains highly susceptible to disruption by various diseases, which significantly contribute to the global challenges of anemia and blood shortages. Current treatments like erythr...
Xiaoyi Sun,Sarra Setrerrahmane,Chencheng Li et al.
Xiaoyi Sun et al.
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades. Currently, most clinically approved therapeutics are small molecules or protein/antibody biologics. Targeted actio...
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics [0.03%]
饮食限制干预：寿命的获益需要抵抗力且受到免疫功能下降和遗传性的限制
Yulin Chen,Anjalika Malik,Karl Lenhard Rudolph
Yulin Chen
Human olfaction: odour coding and cross-modal concept representation in single olfactory cortex neurons [0.03%]
人类嗅觉：嗅觉皮层单个神经元中的气味编码及跨模式概念表达
Antonia Beiersdorfer,Markus Rothermel,Christian Lohr
Antonia Beiersdorfer
Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis [0.03%]
解开RNA密码：一种尿嘧啶RNA修饰驱动糖基RNA生物生成
Marco Sachse,Konstantinos Stellos
Marco Sachse