Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines [0.03%]
小核酸药物的前景：从实验台到临床作为下一代药物的发展进程
Mohan Liu,Yusi Wang,Yibing Zhang et al.
Mohan Liu et al.
The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even cura...
Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation [0.03%]
Epstein-Barr病毒通过KDM5B的上调驱动上皮恶性肿瘤进展的过程中对组蛋白去甲基化酶机制的利用
Ya-Qing Zhou,Jia-Xin Jiang,Shuai He et al.
Ya-Qing Zhou et al.
Epstein-Barr virus (EBV) is a significant epigenetic driver in the development of epithelial-origin nasopharyngeal carcinoma (NPC) and gastric cancer (GC), which together represent 80% of EBV-associated malignancies. Despite its known assoc...
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets [0.03%]
组织巨噬细胞：起源、异质性、生物功能、疾病和治疗靶点
Fan Guan,Ruixuan Wang,Zhenjie Yi et al.
Fan Guan et al.
Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in immune defense, surveillance, and homeostasis. This review systematically discusses the types of hematopoietic progenitors that give rise...
Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies [0.03%]
急性呼吸窘迫综合症的进展：侧重于异质性、病理生理学和治疗策略
Wen Ma,Songling Tang,Peng Yao et al.
Wen Ma et al.
In recent years, the incidence of acute respiratory distress syndrome (ARDS) has been gradually increasing. Despite advances in supportive care, ARDS remains a significant cause of morbidity and mortality in critically ill patients. ARDS is...
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages [0.03%]
宿主FSTL1通过促进炎性巨噬细胞的早期募集在干细胞治疗肝纤维化中起重要作用
Xiaohong Zheng,Siyuan Tian,Ting Li et al.
Xiaohong Zheng et al.
Adult stem cell therapy holds great promise for treating decompensated liver cirrhosis on the basis of animal studies, despite uncertainty about its clinical therapeutic efficacy and unclear underlying mechanisms. Here, we investigated the ...
Redox regulation: mechanisms, biology and therapeutic targets in diseases [0.03%]
氧化还原调节：机制、生物学及其在疾病治疗中的靶点
Bowen Li,Hui Ming,Siyuan Qin et al.
Bowen Li et al.
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both the onset and progression of various diseases. Under physiological conditions, oxidative f...
Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways [0.03%]
纠正：TIFA通过MALT1依赖和不依赖信号通路抑制肝细胞癌进展
Wenzhi Shen,Renle Du,Jun Li et al.
Wenzhi Shen et al.
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness [0.03%]
肠道菌群失调通过传递心理压力激活LRP5/β-连环蛋白通路从而促进癌症干性
Bai Cui,Huandong Luo,Bin He et al.
Bai Cui et al.
Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor gro...
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines [0.03%]
基于肽类的药物研发进展：传递系统，治疗药物和疫苗
Wenjing Xiao,Wenjie Jiang,Zheng Chen et al.
Wenjing Xiao et al.
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. The integration of novel drug design and synthesis techniques, display library technology, delivery systems, bioengineer...
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation [0.03%]
间变上皮细胞：起源于干细胞并促进肠道炎症
Tim Holland,Jochen Mattner
Tim Holland