Malate initiates a proton-sensing pathway essential for pH regulation of inflammation [0.03%]
马来酸启动了一个感应途径，对于pH调节炎症至关重要
Yu-Jia-Nan Chen,Rong-Chen Shi,Yuan-Cai Xiang et al.
Yu-Jia-Nan Chen et al.
Metabolites can double as a signaling modality that initiates physiological adaptations. Metabolism, a chemical language encoding biological information, has been recognized as a powerful principle directing inflammatory responses. Cytosoli...
Apoptotic clearance by stem cells: molecular mechanisms for recognition and phagocytosis of dead cells [0.03%]
干细胞介导的凋亡清除作用：识别及吞噬凋亡细胞的分子机制研究
Feng Liu,Xiaobo Zhou,Ibrahim Akin
Feng Liu
Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane [0.03%]
衣康酸通过烷基化GDI2并将Rab GTPase保留在膜上从而促进病毒感染
Shulei Yin,Yijie Tao,Tianliang Li et al.
Shulei Yin et al.
Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innat...
Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice [0.03%]
校正：洛伐他汀诱导的SHP2介导的神经元线粒体自噬改善小鼠帕金森病症状
Wen Liu,Meijing Wang,Lihong Shen et al.
Wen Liu et al.
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE [0.03%]
解析LolCDE识别和转运脂蛋白的分子机制
Wen Qiao,Chongrong Shen,Yujiao Chen et al.
Wen Qiao et al.
Outer membrane (OM) lipoproteins serve vital roles in Gram-negative bacteria, contributing to their pathogenicity and drug resistance. For these lipoproteins to function, they must be transported from the inner membrane (IM), where they are...
Yingrui Li,Jianlin Du,Songbai Deng et al.
Yingrui Li et al.
Cardiac development is a complex and intricate process involving numerous molecular signals and pathways. Researchers have explored cardiac development through a long journey, starting with early studies observing morphological changes and ...
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial [0.03%]
特瑞普利单抗联合化疗用于晚期非小细胞肺癌一线治疗的疗效：一项随机双盲III期研究最终总体生存分析及生物标志物探索性分析
Jia Zhong,Kailun Fei,Lin Wu et al.
Jia Zhong et al.
A randomized double-blind phase 3 trial (CHOICE-01, NCT03856411) demonstrated that combining toripalimab with chemotherapy substantially improves progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients withou...
Advancing type 1 diabetes therapy: autologous islet transplant breakthrough [0.03%]
推进I型糖尿病治疗：自体胰岛移植取得突破
Ram Abou Zaki,Assam El-Osta
Ram Abou Zaki
Enhao Ma,Xuan Guo,Mingda Hu et al.
Enhao Ma et al.
Modeling and predicting mutations are critical for COVID-19 and similar pandemic preparedness. However, existing predictive models have yet to integrate the regularity and randomness of viral mutations with minimal data requirements. Here, ...