Haipeng Wen,Hui Deng,Bingyan Li et al.
Haipeng Wen et al.
Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochond...
Xiaoxue Zhou,Yuchen Wu,Zhipeng Zhu et al.
Xiaoxue Zhou et al.
The mucosal immune system, as the most extensive peripheral immune network, serves as the frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion and establishing immune tolerance....
Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut [0.03%]
低输入型红氧代谢组学可促进肠道氧化应激代谢调节因子的全局识别
Xina Xiao,Meng Hu,Li Gao et al.
Xina Xiao et al.
Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in...
Correction: CD4 T cell contact drives macrophage cell cycle G0-G1 transition [0.03%]
订正：CD4T细胞接触驱动巨噬细胞周期G0-G1转换
Petra Mlcochova,Na Zhao,Omar Shabana et al.
Petra Mlcochova et al.
A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas [0.03%]
大规模单细胞转录组揭示细菌性肺炎的免疫全景图
Kun Xiao,Yan Cao,Zhihai Han et al.
Kun Xiao et al.
Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need f...
TET2 cascade: a novel regulator of chromatin structure and leukaemogenesis [0.03%]
TET2级联反应：染色质结构和白血病发生的新调节因子
Wolfram C M Dempke,Klaus Fenchel
Wolfram C M Dempke
Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets [0.03%]
生物分子凝聚体的新兴调控机制和功能及其治疗靶点意义
Soyoung Jeon,Yeram Jeon,Ji-Youn Lim et al.
Soyoung Jeon et al.
Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates-membrane-less assemblies formed through th...
Siqi Zhang,Xingkai Wang,Xin Gao et al.
Siqi Zhang et al.
Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases. Radiopharmaceutical therapy, which directly causes systematic and irreparable damage to targeted cell...
In defence of ferroptosis [0.03%]
论辩铁死亡之意义
Francesca Alves,Darius Lane,Triet Phu Minh Nguyen et al.
Francesca Alves et al.
Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases, and unlike other cell death programs the physiological init...
Dynamic allostery: a novel mechanism regulating autocrine and paracrine TGF-β signalling [0.03%]
动态别构效应：一种调节自分泌和旁分泌TGF-β信号传导的新型机制
Hendrik Ungefroren,Jens Uwe Marquardt
Hendrik Ungefroren