CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection [0.03%]
编码保守结构/包膜蛋白的CHIKV mRNA疫苗可广泛交叉预防感染
Xiaoming Liang,Yanan Zhou,Yun Yang et al.
Xiaoming Liang et al.
With the broad spread of the chikungunya virus (CHIKV), there is an increasing demand for more effective and broadly protective vaccines. Here, we designed CHIKV mRNA vaccines containing full-length structural proteins or part of structural...
Molecular classification of hormone receptor-positive /HER2-positive breast cancer reveals potential neoadjuvant therapeutic strategies [0.03%]
激素受体阳性/HER2阳性乳腺癌的分子分类揭示了潜在的新辅助治疗策略
Chao Liu,Lisha Sun,Nan Niu et al.
Chao Liu et al.
Significant heterogeneity exists in hormone receptor (HR)-positive/HER2-positive (HR+/HER2+) breast cancer, contributing to suboptimal pathological complete response rates with conventional neoadjuvant treatment regimens. Overcoming this ch...
Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy [0.03%]
用于肺癌治疗的能够激起强大T细胞反应的鼻内注射RNA疫苗方案
Hongjian Li,Yating Hu,Jingxuan Li et al.
Hongjian Li et al.
The rapid success of RNA vaccines in preventing SARS-CoV-2 has sparked interest in their use for cancer immunotherapy. Although many cancers originate in mucosal tissues, current RNA cancer vaccines are mainly administered non-mucosally. He...
Fibroblastic niches in action: CCL19+ reticular cells drive anti-tumor immunity in lung cancer [0.03%]
纤维状生态位的作用：CCL19+网状细胞驱动肺癌的抗肿瘤免疫反应
Alessandro Ianni,Alejandro Vaquero,Thomas Braun
Alessandro Ianni
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs [0.03%]
通过代谢药物针对乳腺癌中的PI3K抑制剂耐药性问题
Niklas Gremke,Isabelle Besong,Alina Stroh et al.
Niklas Gremke et al.
Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K in...
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy [0.03%]
BCL2家族：从细胞凋亡机制到靶向治疗的新进展
Meike Vogler,Yannick Braun,Victoria M Smith et al.
Meike Vogler et al.
The B cell lymphoma 2 (BCL2) protein family critically controls apoptosis by regulating the release of cytochrome c from mitochondria. In this cutting-edge review, we summarize the basic biology regulating the BCL2 family including canonica...
An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis [0.03%]
器官特异性的意外参与者：天冬氨酸作为信号分子驱动肺转移
Felix C E Vogel,Almut Schulze
Felix C E Vogel
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study [0.03%]
KN026（一种双特异性抗HER2抗体）与KN046（一种抗CTLA4/PD-L1抗体）联用治疗晚期HER2阳性非乳腺癌患者的疗效和安全性：一项Ib期和II期研究的联合分析
Dan Liu,Jifang Gong,Jian Li et al.
Dan Liu et al.
To evaluate the efficacy and safety of KN026, a novel bispecific HER2 (ECD2 and ECD4) antibody, plus KN046, a PD-L1, and CTLA4 bispecific antibody, in patients with advanced HER2-positive solid tumors. We conducted two sequentially designed...
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance [0.03%]
大规模并行检测人类功能变异调节癌症免疫监视
Ying Liu,Yongshuo Liu,Xuran Niu et al.
Ying Liu et al.
Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic efficacy. Somatic mutations in cancer cells...
Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy [0.03%]
细胞质核酸感应作为驱动重症的机制及其治疗进展
Zhaorong Chen,Rayk Behrendt,Lennart Wild et al.
Zhaorong Chen et al.
Nucleic acids from both self- and non-self-sources act as vital danger signals that trigger immune responses. Critical illnesses such as acute respiratory distress syndrome, sepsis, trauma and ischemia lead to the aberrant cytosolic accumul...