The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis [0.03%]
隐秘的长链非编码RNA编码微蛋白TPM3P9驱动致癌性转录剪接和肿瘤发生
Kun Meng,Yuying Li,Xiaoyi Yuan et al.
Kun Meng et al.
Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these microproteins in alternati...
Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use [0.03%]
人乳头瘤病毒在癌症中的作用：致癌机制与临床应用
Yu Zhang,Ke Qiu,Jianjun Ren et al.
Yu Zhang et al.
Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stran...
Artificial intelligence propels lung cancer screening: innovations and the challenges of explainability and reproducibility [0.03%]
人工智能推动肺癌筛查：创新及可解释性和重现性的挑战
Mario Mascalchi,Chiara Marzi,Stefano Diciotti
Mario Mascalchi
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment [0.03%]
肝癌微环境中VCP下游代谢产物甘油-3-磷酸(G3P)抑制CD8+t细胞功能
Cheng Cheng,Qingrui Zha,Linmao Sun et al.
Cheng Cheng et al.
CD8+T cells within the tumor microenvironment (TME) are often functionally impaired, which limits their ability to mount effective anti-tumor responses. However, the molecular mechanisms behind this dysfunction remain incompletely understoo...
Identification of glutamine as a potential therapeutic target in dry eye disease [0.03%]
谷氨酰胺有望成为干眼病的治疗靶点
Xiaoniao Chen,Chuyue Zhang,Fei Peng et al.
Xiaoniao Chen et al.
Dry eye disease (DED) is a prevalent inflammatory condition significantly impacting quality of life, yet lacks effective pharmacological therapies. Herein, we proposed a novel approach to modulate the inflammation through metabolic remodeli...
Immunotherapy in ovarian cancer: spatial functional genomics to unravel resistance mechanisms [0.03%]
基于空间功能基因组学解析卵巢癌免疫治疗耐药机制
Martina Rausch,Karlotta Bartels,Josef Leibold
Martina Rausch
Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells [0.03%]
靶向SRSF1通过同时作用于CD8+T细胞和肿瘤细胞来改善癌症免疫治疗
Gui-Qi Zhu,Zheng Tang,Tian-Hao Chu et al.
Gui-Qi Zhu et al.
Serine arginine-rich splicing factor 1 (SRSF1) is a key oncogenic splicing factor in various cancers, promoting abnormal gene expression through post-translational regulation. Although the protumoral function of SRSF1 is well-established, t...
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage [0.03%]
异噁唑类化合物通过靶向TM4SF5和SLAMF7的连接恢复肝癌发生过程中的NK细胞免疫监视作用
Ji Eon Kim,Hyun Su Kim,Wonsik Kim et al.
Ji Eon Kim et al.
Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the id...
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma [0.03%]
双重靶向PD-L1和4-1BB以克服滤泡性淋巴瘤地塞米明耐药的树突状细胞介导机制
Zhong Zheng,Jian-Biao Wang,Rui Sun et al.
Zhong Zheng et al.
Immunomodulatory agent lenalidomide is effective in treating follicular lymphoma (FL). We conducted the first trial of immunotherapy rituximab plus lenalidomide in newly diagnosed FL in China (NCT03715309). One-hundred and fifteen patients ...
Severin Guetter,Kaiji Fan,Hendrik Poeck
Severin Guetter