The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications [0.03%]
免疫系统与心血管疾病：从基本机制到治疗意义
Xiaoyan Wang,Liming Chen,Jianming Wei et al.
Xiaoyan Wang et al.
Immune system plays a crucial role in the physiological and pathological regulation of the cardiovascular system. The exploration history and milestones of immune system in cardiovascular diseases (CVDs) have evolved from the initial discov...
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma [0.03%]
PKMYT1激酶通过改善骨肉瘤对顺铂的敏感性来抑制疾病进展
Binfeng Liu,Wei Li,Wenchao Zhang et al.
Binfeng Liu et al.
Cisplatin (DDP) remains a cornerstone therapy for osteosarcoma (OS); however, pervasive resistance severely limits its clinical efficacy and worsens patient outcomes. Developing strategies to enhance the chemotherapeutic responsiveness of O...
Targeting conserved epitopes in structural proteins: a next-generation vaccine strategy against the newly identified HKU5-CoV-2 virus [0.03%]
针对结构蛋白的保守表位进行靶向：一种下一代抗新发现HKU5-CoV-2病毒疫苗策略
Leonardo Pereira de Araújo,Evandro Neves Silva,André Luiz Caliari Costa et al.
Leonardo Pereira de Araújo et al.
Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation [0.03%]
老化中性粒细胞的大囊泡：促进炎症消退的新机制
Christopher Dietz-Fricke,Florian R Greten
Christopher Dietz-Fricke
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives [0.03%]
血管内皮生长因子信号通路的健康与疾病：从分子机制到治疗视角
Chunsik Lee,Myung-Jin Kim,Anil Kumar et al.
Chunsik Lee et al.
Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maint...
Melatonin synergizes with prostaglandin E2 to enhance YAP-mediated regenerative epithelial cell emergence during intestinal repair [0.03%]
褪黑素通过与前列腺素E2协同作用增强YAP介导的再生上皮细胞在肠道修复过程中的出现
Yoojin Seo,Ji-Su Ahn,Hansong Lee et al.
Yoojin Seo et al.
Deep mining in the dorsal raphe: cholecystokinin-expressing neurons encode satiation-related cues to regulate meal size [0.03%]
脑干背缝核中的深度挖掘：胆囊收缩素阳性神经元通过编码饱腹感相关的线索来调节进食量
Niels Röhrdanz,Peer Wulff,Kira Balueva
Niels Röhrdanz
Platelets and diseases: signal transduction and advances in targeted therapy [0.03%]
血小板与疾病：信号转导及靶向治疗进展
Yuchen Tian,Yao Zong,Yidan Pang et al.
Yuchen Tian et al.
Platelets are essential anucleate blood cells that play pivotal roles in hemostasis, tissue repair, and immune modulation. Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized stru...
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction [0.03%]
通过诱导杀老细胞和免疫反应消除巨大型先天性黑色素痣的BCL2靶向治疗
Boxuan Wei,Qingxiong Yu,Jiamin Jin et al.
Boxuan Wei et al.
Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. Existing treatments like surgical resection a...