Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [0.03%]
茎环结合蛋白通过-1程序化核糖体框移促进SARS-CoV-2复制
Tanxiu Chen,Ruimin Zhu,Tingfu Du et al.
Tanxiu Chen et al.
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins. To date, the host factors influencing this process re...
Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer [0.03%]
利用双效ENPP1/ATM敲低削弱DNA修复能力提高放免疗疗效以治疗三阴性乳腺癌的研究
Borja Ruiz-Fernández de Córdoba,Karmele Valencia,Connor Welch et al.
Borja Ruiz-Fernández de Córdoba et al.
The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance. However, the precise mechanisms rem...
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances [0.03%]
氧化应激、炎症和衰老情况下的线粒体：从机制到治疗进展
Xieyang Xu,Yan Pang,Xianqun Fan
Xieyang Xu
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces...
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation [0.03%]
Mitsugumin 53通过促进干细胞分化来缓解肠损伤和炎症
Yumeng Pei,Meng Fang,Hong-Kun Wu et al.
Yumeng Pei et al.
Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased linea...
Limited but powerful toolbox: myeloid cells as critical immunomodulators in glioma progression [0.03%]
有限但强大的工具箱：髓系细胞在胶质瘤进展中的关键免疫调节作用
Yun Liu,Jincheng Fang,Roman Sankowski
Yun Liu
Single-cell transcriptional dissection illuminates an evolution of immunosuppressive microenvironment during pancreatic ductal adenocarcinoma metastasis [0.03%]
单细胞转录组解析揭示了胰腺导管腺癌转移过程中免疫抑制微环境的演变规律
Xiaowei Liu,Jinen Song,Meiling Yuan et al.
Xiaowei Liu et al.
How the host immune system loses its surveillance function during the evolution from normal cell to malignancy is still largely unknown. Here, we investigate the dynamics changes of the pancreatic ductal adenocarcinoma (PDAC) tumor microenv...
Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production [0.03%]
微生物代谢物丁酸通过抑制Tfh13介导的IgE产生来缓解哮喘
Baichao Yu,Chong Pei,Wenjun Peng et al.
Baichao Yu et al.
Gut microbiota-derived short-chain fatty acids (SCFAs) impact asthma outcomes, highlighting the importance of understanding the disease mechanisms through the gut-lung axis. In this study, we identified that among SCFAs, butyrate uniquely a...
Development and validation of dynamic clinical subphenotypes in acute pancreatitis patients using vital sign trajectories in intensive care units: a multinational cohort study [0.03%]
基于重症监护病房急性胰腺炎患者生命体征轨迹的临床亚型的发展和验证：一项跨国队列研究
Zichen Wang,Wen Wang,Jiayue Xu et al.
Zichen Wang et al.
Acute pancreatitis (AP) is a heterogeneous inflammatory condition. Although emerging therapeutic strategies targeting pathways such as calcium signaling, TNF-α, the NLRP3 inflammasome, and HMGB1 have shown promise, their efficacy may be li...
Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity [0.03%]
肿瘤相关中性粒细胞的治疗潜力：双重作用和表型可塑性
Yanting Zhou,Guobo Shen,Xikun Zhou et al.
Yanting Zhou et al.
Neutrophils are the first line of defense in nonspecific immunity (innate immunity) and interact with other immune cells to participate in specific defense mechanisms (adaptive immunity). Studies have shown that the tumor microenvironment (...
Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment [0.03%]
人脐带间质干细胞来源外泌体雾化吸入治疗肺纤维化的临床研究
Meng Li,Huaping Huang,Xiaofei Wei et al.
Meng Li et al.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are recognized as a promising strategy for cell-free therapy, however, their therapeutic role in pulmonary fibrosis remains unrevealed. Here, we report the safety and efficac...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2025 Jun 4;10(1):179. DOI:10.1038/s41392-025-02262-3 2025