Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors [0.03%]
奥纳西替布联合特瑞普利单抗治疗晚期实体瘤的多中心Ⅰ/Ⅱ期研究
Pei Shu,Xiaoyu Li,Qi Zhou et al.
Pei Shu et al.
Preclinical studies have indicated that the combination of mTORC1/2 inhibitors with PD-1 antibodies exhibits synergistic effects on solid tumors. However, no clinical data supporting this combination have been reported. Therefore, we conduc...
Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models [0.03%]
MAPK驱动的衰老多组学解析发现了KIAA1549::BRAF融合阳性儿童低级别胶质瘤模型中的治疗弱点
Romain Sigaud,Anja Stefanski,Florian Selt et al.
Romain Sigaud et al.
Pilocytic astrocytomas (PA), the most common pediatric low-grade gliomas (pLGGs), are characterized by genetic MAPK pathway alterations leading to constitutive activation and oncogene-induced senescence (OIS) accompanied with the senescence...
Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function [0.03%]
针对RBPJ诱导调节性T细胞治疗：增强稳定性和功能
Niklas Beumer,Michael Delacher
Niklas Beumer
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury [0.03%]
单次和重复性创伤性脑损伤中特异性蛋白质标志物及神经退行性风险的评估
Sarah Mantash,Soulaimane Aboulouard,Hassan Dakik et al.
Sarah Mantash et al.
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underl...
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity [0.03%]
TSC22家族成员3通过自然杀伤细胞将药物超敏反应与CD8⁺T细胞介导的免疫应答联系在一起
Lele Sun,Pengcheng Huai,Zhenzhen Wang et al.
Lele Sun et al.
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors inf...
Qilong Li,Tong Liu,Kunying Lv et al.
Qilong Li et al.
Malaria, caused by Plasmodium parasites and transmitted by Anopheles mosquitoes, greatly impacts public health and socioeconomic development, particularly in sub-Saharan African countries. Despite advances in malaria treatment and preventio...
Gerard J Nuovo,Esmerina Tili,Carlo M Croce
Gerard J Nuovo
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation [0.03%]
一项II期试验：在具有KRAS G12C突变的晚期实体瘤中，GARSORASIB（一种KRAS G12C抑制剂）联合或不联合西妥昔单抗（EGFR抗体）用于结直肠癌患者的临床研究
Dan-Yun Ruan,Hao-Xiang Wu,Ye Xu et al.
Dan-Yun Ruan et al.
Mutations in the KRAS gene have long been implicated in the pathogenesis of colorectal cancer (CRC). KRAS G12C inhibitors overcome the "undruggable" challenge, enabling precision therapy. Garsorasib (D-1553), a highly potent and selective K...
Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [0.03%]
嘌呤核苷磷酸酶通过嘌呤补救途径主导流感病毒的复制和宿主过度炎症反应
Yang Yue,Qingyu Li,Changguo Chen et al.
Yang Yue et al.
Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown. By integrating the plasma proteomics data of the IAV-i...
Qing Huang,Yuanxiang Li,Yingdan Huang et al.
Qing Huang et al.
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitabl...