Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments [0.03%]
肿瘤相关巨噬细胞在肿瘤微环境中的双重作用及治疗靶向性研究
Jiasheng Xu,Lei Ding,Jianfeng Mei et al.
Jiasheng Xu et al.
Tumor-associated macrophages (TAMs), derived from circulating monocytes recruited to tumor sites via chemotactic signals such as C-C motif ligand 2 (CCL2) and colony-stimulating factor-1 (CSF-1), are pivotal components of the tumor microenv...
Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction [0.03%]
COVID-19感染人类大脑中的主要神经病理学：炎症、血管周细胞主要功能障碍和小胶质细胞功能障碍
Peter Illes,Hai-Yan Yin,Yong Tang
Peter Illes
Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases [0.03%]
血红蛋白的假过氧化物酶活性及其作为氧化应激相关疾病药物靶点的作用
Woojin Won,Elijah Hwejin Lee,Lizaveta Gotina et al.
Woojin Won et al.
Hemoglobin (Hb) is well known for transporting oxygen in the blood, but its role in the brain remains poorly understood. Here, we identified Hb in the cytosol, mitochondria, and nuclei of hippocampal and substantia nigra astrocytes and dopa...
A multicenter single-arm clinical study of Chinese children's cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol [0.03%]
中国儿童急性早幼粒细胞白血病诊疗方案（2017版）多中心单臂临床研究（CCCG-APL-2017）
Lixian Chang,Ju Gao,Xiaoying Lei et al.
Lixian Chang et al.
The Realgar-Indigo Naturalis formula (RIF) is a proprietary Chinese medicine, which is one of the important drugs in the treatment of pediatric acute promyelocytic leukemia (APL). However, the dose of RIF in clinical application is not unif...
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies [0.03%]
间充质干细胞在治疗人类疾病中的作用：分子机制和临床研究
Xia Han,Rongdong Liao,Xiang Li et al.
Xia Han et al.
Mesenchymal stem cells (MSCs) have emerged as a highly promising strategy in regenerative medicine due to their self-renewal, pluripotency and immunomodulatory properties. MSCs are nonhematopoietic, multipotent stem cells that can different...
Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells [0.03%]
Piezo1介导的机械转导调节组2固有淋巴样细胞的翻译活性、功能和肺部致病性
MinYeong Lim,Seonjun Park,Yoon Ha Joo et al.
MinYeong Lim et al.
Group 2 innate lymphoid cells (ILC2s) are central effectors of type 2 immune responses in the lung; however, how mechanical cues regulate their function remains unclear. Here, we identified the mechanosensitive ion channel Piezo1 as a key r...
Fencing the genome: ubiquitin signaling restricts heterochromatin spread [0.03%]
用泛素信号划界基因组：限制异染色质扩散
Collin Bakker,Joanna Paulson,Nitika Taneja
Collin Bakker
First-line tislelizumab and ociperlimab combined with gemcitabine and cisplatin in advanced biliary tract cancer (ZSAB-TOP): a multicenter, single-arm, phase 2 study [0.03%]
替雷利珠单抗和奥希珀利单抗联合吉西他滨和顺铂作为一线治疗药物用于晚期胆道癌的多中心、开放性、单组Ⅱ期研究(ZSAB-TOP)
Guoming Shi,Xiaoyong Huang,Liang Ma et al.
Guoming Shi et al.
Adding a PD-1/PD-L1 inhibitor to gemcitabine plus cisplatin (GemCis) has shown survival benefits in advanced biliary tract cancer (BTC). Dual inhibition of PD-1/PD-L1 and TIGIT may act synergistically, and further enhance antitumor effects....
F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair [0.03%]
F-box/LRR重复蛋白12通过重新调控小胶质细胞抑制瘢痕形成并实现成人脊髓损伤修复
Xu Xu,Feng Gao,Qixin Chen et al.
Xu Xu et al.
Scarring is an insurmountable obstacle for axonal regeneration in recovery from spinal cord injury (SCI). It impedes the repair effects of therapeutic targets in cortical neurons, such as PTEN-/- and hyper-IL-6, which cannot break through d...
NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts [0.03%]
NADPH氧化酶1/4双抑制作用可削弱转化生长因子-β在胆管癌相关成纤维细胞中的促肿瘤生成效应
Josep Amengual,Ester Gonzalez-Sanchez,Mariana Yáñez-Bartolome et al.
Josep Amengual et al.
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment. In intrahepatic cholang...