Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation [0.03%]
二甲双胍通过促进Sirt1和M2巨噬细胞介导的抗炎激活来抑制草酸钙晶体引起的肾脏损伤
Haoran Liu,Chen Duan,Xiaoqi Yang et al.
Haoran Liu et al.
Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance [0.03%]
miR-301a/Fra-2/GLIPR1轴在肺癌顺铂耐药中的作用
Gian Luca Rampioni Vinciguerra,Marina Capece,Rosario Distefano et al.
Gian Luca Rampioni Vinciguerra et al.
Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment [0.03%]
肿瘤源性miR-20b-5p通过重塑肿瘤微环境促进食管鳞状细胞癌淋巴转移
Zitong Zhao,Liyan Xue,Leilei Zheng et al.
Zitong Zhao et al.
Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model [0.03%]
抗Aβ抗体的效应子Fc在类似阿尔茨海默病的小鼠模型中诱导突触丢失和认知缺陷
Xiao-Ying Sun,Xiao-Lin Yu,Jie Zhu et al.
Xiao-Ying Sun et al.
Passive immunotherapy is one of the most promising interventions for Alzheimer's disease (AD). However, almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitive...
Wenqi Zhao,Suowen Xu,Jianping Weng
Wenqi Zhao
Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity [0.03%]
邻近诱导的IL-2与IL-2Rα共价结合可选择性激活调节T细胞并抑制自身免疫反应
Bo Zhang,Jiaqi Sun,Yeshuang Yuan et al.
Bo Zhang et al.
Interleukin-2 (IL-2) is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells (Tregs) and effector cells, leading to paradoxical consequences. Here, we report a strategy that exploited genetic code e...
Application of metabolomics in urolithiasis: the discovery and usage of succinate [0.03%]
代谢组学在尿石症中的应用：琥珀酸的发现和利用
Xiu-Zhen Zhang,Xiong-Xin Lei,Yan-Lin Jiang et al.
Xiu-Zhen Zhang et al.
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regulated by crystal growth modifie...
Immunological and metabolic characteristics of the Omicron variants infection [0.03%]
奥密克戎变异株感染的免疫和代谢特征
Jiejie Geng,Xu Yang,Kun Wang et al.
Jiejie Geng et al.
The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants inf...
Diffuse midline glioma treated with epigenetic agent-based immunotherapy [0.03%]
使用表观遗传药物进行免疫治疗的弥漫性中线胶质瘤
Linkai Jing,Zhihong Qian,Qiang Gao et al.
Linkai Jing et al.
Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1 [0.03%]
细胞微粒中的化疗药物通过激活溶酶体P450和核hnRNPA2B1重置巨噬细胞的抗肿瘤活性
Keke Wei,Huafeng Zhang,Shuaishuai Yang et al.
Keke Wei et al.
Macrophages in tumors (tumor-associated macrophages, TAMs), a major population within most tumors, play key homeostatic functions by stimulating angiogenesis, enhancing tumor cell growth, and suppressing antitumor immunity. Resetting TAMs b...