Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms [0.03%]
雷公藤红素代谢重编程促炎性巨噬细胞有效改善类风湿关节炎症状的新机制研究
Na Jia,Yunzhen Gao,Min Li et al.
Na Jia et al.
Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. ...
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression [0.03%]
中性粒细胞胞外陷阱与心肌细胞相互作用促进房颤进展
Li He,Ruiqi Liu,Honghua Yue et al.
Li He et al.
Atrial fibrillation (AF) is a frequent arrhythmia associated with cardiovascular morbidity and mortality. Neutrophil extracellular traps (NETs) are DNA fragments with cytoplasm proteins released from neutrophils, which are involved in vario...
Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme [0.03%]
一种基于仿生蛋白的单原子纳米酶协同催化治疗摧毁结直肠癌病原体肿瘤共生体的研究
Xinyue Wang,Qian Chen,Yefei Zhu et al.
Xinyue Wang et al.
The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology. Several intratumoral bacteria which have been identified as pathogens of cancer that induce ...
Tingmei Zhao,Yulong Cai,Yujie Jiang et al.
Tingmei Zhao et al.
Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate immune response controls the antigen-sp...
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness [0.03%]
癌细胞利用微环境神经信号活化核线粒体协调以获得干细胞特性
Bin He,Rui Gao,Shasha Lv et al.
Bin He et al.
Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive. Here, a pan-cancer...
Yanjiao Li,Jingjing Hou,Zhong Sun et al.
Yanjiao Li et al.
Neutrophil-sourced TNF in cancer: deciphering an intricate orchestrator of immunosuppressive communication in the tumor microenvironment [0.03%]
中性粒细胞来源的TNF在癌症中的作用：解析肿瘤微环境中免疫抑制通讯的一个复杂调控者
Xinyuan Zhao,Ye Lu,Li Cui
Xinyuan Zhao
Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases [0.03%]
TLR2/6激动剂增强mRNA肿瘤疫苗和传染病疫苗的作用
Yangzhuo Gu,Jingyun Yang,Cai He et al.
Yangzhuo Gu et al.
mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases. Improvements of mRNA vaccines have been underway, among which boosting of efficacy...
SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells [0.03%]
新冠病毒刺突蛋白受体结合域干扰胞内钙稳态并损害肺血管内皮细胞功能
Kai Yang,Shiyun Liu,Han Yan et al.
Kai Yang et al.
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2...