2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis [0.03%]
2-APQC通过调节线粒体稳态缓解心肌肥大和纤维化：一种激活Sirtuin-3(SIRT3)的small-molecule激活剂
Fu Peng,Minru Liao,Wenke Jin et al.
Fu Peng et al.
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently...
Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain [0.03%]
一种针对SARS-CoV-2刺突蛋白N端结构域保守表位的IgM样纳米抗体增强效力
Bo Liu,Honghui Liu,Pu Han et al.
Bo Liu et al.
Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such a...
Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study [0.03%]
新冠灭活疫苗和重组蛋白疫苗序贯接种在老年人群中的安全性、免疫原性和保护效力：前瞻性队列研究
Hong-Hong Liu,Yunbo Xie,Bao-Peng Yang et al.
Hong-Hong Liu et al.
The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 elderly and 73 young participants ...
Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT [0.03%]
TPR-CHAT对CRISPR-Cas7-11负调控的结构基础
Tian Hong,Qinghua Luo,Haiyun Ma et al.
Tian Hong et al.
CRISPR‒Cas7-11 is a Type III-E CRISPR-associated nuclease that functions as a potent RNA editing tool. Tetratrico-peptide repeat fused with Cas/HEF1-associated signal transducer (TPR-CHAT) acts as a regulatory protein that interacts with C...
SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation [0.03%]
SARS-CoV-2异常提高线粒体生物能以促进病毒的大量增殖
Hye Jin Shin,Wooseong Lee,Keun Bon Ku et al.
Hye Jin Shin et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 'highly transmissible respiratory pathogen, leading to severe multi-organ damage. However, knowledge regarding SARS-CoV-2-induced cellular alterations is limited. In this stu...
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies [0.03%]
三价XBB疫苗诱导抗体对包括JN.1和BA.2.87.1谱系在内的SARS-CoV-2变异株的广义中和作用
Xun Wang,Shujun Jiang,Wentai Ma et al.
Xun Wang et al.
Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention [0.03%]
血小板生成素和亚甲基四氢叶酸还原酶基因多态性对卒中一级预防叶酸疗效的影响
Yuncong Shi,Zhengzhipeng Zhang,Binyan Wang et al.
Yuncong Shi et al.
Previous studies have shown that low platelet count combined with high plasma total homocysteine (tHcy) increased stroke risk and can be lowered by 73% with folic acid. However, the combined role of other platelet activation parameters and ...
Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer [0.03%]
揭示元凶：结直肠癌中的弗氏菌谱系
Johannes Betge,Matthias P Ebert
Johannes Betge
A pathological joint-liver axis mediated by matrikine-activated CD4+ T cells [0.03%]
病理性的关节-肝脏轴通过基质肽激活的CD4+T细胞介导
Junzhi Yi,Hui Zhang,Fangyuan Bao et al.
Junzhi Yi et al.
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleedin...
CAR-T overdrive: harnessing inosine for metabolic rewiring and stemness induction [0.03%]
CAR-T过载：利用次黄嘌呤进行代谢重构和干细胞诱导
Martí Farrera-Sal,Michael Schmueck-Henneresse
Martí Farrera-Sal