Potential recombination between SARS-CoV-2 and MERS-CoV: calls for the development of Pan-CoV vaccines [0.03%]
SARS-CoV-2与MERS-CoV潜在重组的可能：开发泛冠状病毒疫苗的呼吁
Qiao Wang,Lujia Sun,Shibo Jiang
Qiao Wang
Wenyan Zhou,Junxin Lin,Yan Xie et al.
Wenyan Zhou et al.
Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium [0.03%]
活动纤毛和微绒毛：穿透黏液屏障并感染呼吸道上皮的新型冠状病毒同谋者
Peng Su,Fangfang Zhou,Long Zhang
Peng Su
SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation [0.03%]
SIRT7通过UPR活化同时促进细胞存活和免疫逃逸从而驱动黑色素瘤进展
Xiuli Yi,Huina Wang,Yuqi Yang et al.
Xiuli Yi et al.
Melanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effe...
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications [0.03%]
心脏衰老中的代谢景观：分子生物学和治疗意义的见解
Saiyang Xie,Si-Chi Xu,Wei Deng et al.
Saiyang Xie et al.
Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as a hallmark of malignancy, but recent studies have shed light on its role in cardiovas...
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases [0.03%]
细胞年轻化：针对疾病细胞复苏的分子机制和潜在治疗干预措施
Shuaifei Ji,Mingchen Xiong,Huating Chen et al.
Shuaifei Ji et al.
The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells or organisms more youthful characteristics through variou...
AlphaFold2 and its applications in the fields of biology and medicine [0.03%]
AlphaFold2及其在生物和医学领域的应用
Zhenyu Yang,Xiaoxi Zeng,Yi Zhao et al.
Zhenyu Yang et al.
AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind that can predict three-dimensional (3D) structures of proteins from amino acid sequences with atomic-level accuracy. Protein structure prediction is one of the...
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis [0.03%]
补体β₂糖蛋白I抗体介导补体细胞β₂糖蛋白I抗体介导高同型半胱氨酸血症加重的高血压肾小球损伤通过触发铁死亡
Xing Du,Xiaolong Ma,Ying Tan et al.
Xing Du et al.
Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it is unknown whether this pathway mediates kidney inj...
Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development [0.03%]
合成生物学启发的细胞工程在诊断、治疗及药物开发中的应用
Ninglin Zhao,Yingjie Song,Xiangqian Xie et al.
Ninglin Zhao et al.
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram and engineer cells for improved performance, novel functions, and diverse applications. Such cell engineering resources can play a critical role in the ...
Tumor-draining lymph node-derived tumor-specific memory CD8+ T cells: a key player in PD-1/PD-L1 immunotherapy [0.03%]
肿瘤引流淋巴结衍生的肿瘤特异性记忆CD8+t细胞在pd-1/pd-l1免疫治疗中的关键作用
Enzhi Yin,Nan Sun,Jie He
Enzhi Yin