Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1 [0.03%]
神经纤维瘤病Ⅰ型患者接种新冠疫苗后的中和抗体反应
Qiao-Ling Ruan,Zhi-Chao Wang,Cheng-Jiang Wei et al.
Qiao-Ling Ruan et al.
RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification [0.03%]
RPS15通过识别m6A修饰促进食管鳞癌发生发展
Yahui Zhao,Yang Li,Rui Zhu et al.
Yahui Zhao et al.
Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor prognosis. Using a CRISPR synergistic activation mediator (SAM) system library targeting 89 ribosomal proteins (RPs) to sc...
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis [0.03%]
基于类器官的单细胞时空基因表达谱解析人类胚胎发育及造血发生过程
Yiming Chao,Yang Xiang,Jiashun Xiao et al.
Yiming Chao et al.
Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development [0.03%]
高毒力肺炎克雷伯菌导致高死亡率的分子机制及其有效治疗措施的研发进展
Qi Xu,Miaomiao Xie,Xiaoxuan Liu et al.
Qi Xu et al.
Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke [0.03%]
生物标志物和基因组分析揭示了非心脏栓塞性缺血性卒中的分子特征
Lingling Ding,Yu Liu,Xia Meng et al.
Lingling Ding et al.
Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCIS), which constitutes the majority of AIS cases, is highly heterogeneous, thus requiring precision medicine treatments...
Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade [0.03%]
核受体AhR和膜PD-L1在预测非小细胞肺癌PD-1阻断反应中的作用
Si-Chong Han,Gui-Zhen Wang,Ya-Ning Yang et al.
Si-Chong Han et al.
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies [0.03%]
代谢性疾病中靶向蛋白质修饰的分子机制及针对性疗法
Xiumei Wu,Mengyun Xu,Mengya Geng et al.
Xiumei Wu et al.
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is metabolic diseases, which affect people of all ages and usually manifest their pathobiology ...
Di Wu,Qi Chen,Xiaojie Chen et al.
Di Wu et al.
Blood-brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical dr...
3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice [0.03%]
3-羟丁酸通过抑制PPTGamino acid SER273磷酸化改善2型糖尿病小鼠的胰岛素抵抗
Yudian Zhang,Zihua Li,Xinyi Liu et al.
Yudian Zhang et al.
3-Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the body in the liver. Previous studies have shown that 3HB can reduce blood glucose level in type 2 diabetic (T2D) patients. However, there is no systematic s...