Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer [0.03%]
脱泛素酶USP9x调节非小细胞肺癌中的脯氨酸生物合成途径
Tina Becirovic,Boxi Zhang,Cecilia Lindskog et al.
Tina Becirovic et al.
Metabolic rewiring has been recognized as a hallmark of malignant transformation, supplying the biosynthetic and energetic demands for rapid cancer cell proliferation and tumor progression. A comprehensive understanding of the regulatory me...
EZH2-STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma [0.03%]
EZH2-STAT3信号通路调节胶质母细胞瘤中GSDMD介导的pyroptosis
Dong Yu,Shuai Wang,Jiajun Wang et al.
Dong Yu et al.
Glioblastoma multiforme (GBM) is the most therapeutically challenging primary brain tumor owing to the unique physiological structure of the blood-brain barrier. Lately, research on targeted therapy for gliomas has shifted focus toward the ...
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis [0.03%]
脂毒性诱导的SCGN下调通过NLRP3介导β细胞焦亡促进胰岛β细胞凋亡
Shuhui Ouyang,Sunmin Xiang,Xin Wang et al.
Shuhui Ouyang et al.
Lipotoxicity is a well-established phenomenon that could exacerbate damage to islet β-cells and play a significant role in the development of type 2 diabetes, the underlying mechanisms of which, however, remain unclear. In lipotoxic condit...
GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells [0.03%]
GLUT1抑制剂BAY-876可诱导头颈鳞癌细胞凋亡并增强苦味受体激动剂的抗癌作用
Zoey A Miller,Sahil Muthuswami,Arielle Mueller et al.
Zoey A Miller et al.
Head and neck squamous cell carcinomas (HNSCCs) are cancers that arise in the mucosa of the upper aerodigestive tract. The five-year patient survival rate is ~50%. Treatment includes surgery, radiation, and/or chemotherapy and is associated...
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma [0.03%]
HIF-1失活赋予HIF-2驱动侵袭性髓母细胞瘤的缺氧适应能力
J Contenti,Y Guo,M Larcher et al.
J Contenti et al.
Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its genetics and biology remain less clear than the other groups, and it has a poor pr...
Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes [0.03%]
表柔比星通过破坏ATP6V0A2依赖的溶酶体酸化并触发心肌细胞铁死亡来诱导心脏毒性
Mingming Zhang,Xin Wu,Yuting Wen et al.
Mingming Zhang et al.
Epirubicin (EPI) is effective in the treatment of malignant cancers, but its application is limited by life-threatening cardiotoxicity. Iron homeostasis disturbance has been implicated in anthracycline induced cardiotoxicity (AIC), and ferr...
The recruitment of CD8+ T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma [0.03%]
YBX1稳定通过募集CD8⁺T细胞消除MIR155HG在肺腺癌中的致癌作用
Rutao Li,Yijian Zhang,Anpeng Wang et al.
Rutao Li et al.
Previous studies revealed that MIR155HG possessed an oncogenic role in many types of tumors including lung adenocarcinoma (LUAD), along with higher expression in tumors. However, in our study, we observed a positive correlation between MIR1...
Ca2+ signals are essential for T-cell proliferation, while Zn2+ signals are necessary for T helper cell 1 differentiation [0.03%]
钙信号对于T细胞增殖是必不可少的，而锌信号对于Th1细胞分化是必要的
Jana Jakobs,Jens Bertram,Lothar Rink
Jana Jakobs
The regulation of T-cell fate is crucial for the balance between infection control and tolerance. Calcium (Ca2+) and zinc (Zn2+) signals are both induced after T-cell stimulation, but their specific roles in the fate of activation and diffe...
The membrane insertion of the pro-apoptotic protein Bax is a Tom22-dependent multi-step process: a study in nanodiscs [0.03%]
Bax促凋亡蛋白的膜插入是一种依赖于Tom22的多步过程：纳米盘中的研究
Akandé Rouchidane Eyitayo,Laetitia Daury,Muriel Priault et al.
Akandé Rouchidane Eyitayo et al.
Membrane insertion of the pro-apoptotic protein Bax was investigated by setting up cell-free synthesis of full-length Bax in the presence of pre-formed nanodiscs. While Bax was spontaneously poorly inserted in nanodiscs, co-synthesis with t...
Long noncoding RNA profiling unveils LINC00960 as unfavorable prognostic biomarker promoting triple negative breast cancer progression [0.03%]
长非编码RNA谱分析发现LINC00960是不利的预后生物标志物可促进三阴性乳腺癌进展
Ramesh Elango,Vishnubalaji Radhakrishnan,Sameera Rashid et al.
Ramesh Elango et al.
Long noncoding RNAs (lncRNAs) play a critical role in breast cancer pathogenesis, including Triple-Negative Breast Cancer (TNBC) subtype. Identifying the lncRNA expression patterns across different breast cancer subtypes could provide valua...