RNA binding motif protein RBM41 promotes colorectal tumorigenesis by impeding the maturation of NDRG1 pre-mRNA [0.03%]
RNA结合基序蛋白RBM41通过阻碍NDRG1前体mRNA的成熟促进结直肠肿瘤发生
Yanxin Liu,Jianfeng Mu,Jiming Yu et al.
Yanxin Liu et al.
Colorectal cancer (CRC) is a prevalent and highly lethal malignancy. RNA-binding motif (RBM) proteins have been demonstrated in CRC pathogenesis. However, the biological function and regulatory mechanisms of RBM41 in CRC remain poorly under...
Newly identified invasion drivers define the tumor front in oral squamous cell carcinoma [0.03%]
newly identified invasion drivers define the tumor front in oral squamous cell carcinoma（口腔鳞状细胞癌中 newly identified invasion drivers 定义肿瘤前沿）
Guillermo Flores,Slyn Uaroon,Juan A R Garay et al.
Guillermo Flores et al.
Cells at the invasive front of oral squamous cell carcinoma (OSCC) occupy a partial epithelial-to-mesenchymal transition (p-EMT) state that drives invasion and therapeutic resistance yet remains poorly understood. To define the regulators o...
PER2 reprograms intracellular cholesterol synthesis to inhibit oral squamous cell carcinoma and the chronotherapeutic efficacy of simvastatin [0.03%]
PER2通过重新编程细胞内胆固醇合成来抑制口腔鳞状细胞癌及辛伐他汀的时辰治疗效应
Shilin Yin,Fang Yang,Zhiwei Zhang et al.
Shilin Yin et al.
Dysregulation of cholesterol homeostasis is closely associated with the development of various cancers, but the underlying mechanisms remain unclear. This study found that the circadian clock gene Period 2 (PER2) is downregulated in oral sq...
Thioredoxin system dysregulation and calpain activation drive myocardial disulfidptosis via pathological disulfide bonds remodeling [0.03%]
心肌病理性二硫键重塑驱动的心肌脱硫症促进线粒体功能障碍的新机制研究
Aling Tang,Bingqing Chen,Weizhen Zhang et al.
Aling Tang et al.
Myocardial infarction (MI) remains a leading cause of death and disability worldwide, yet the molecular mechanisms underlying cardiomyocyte death during ischemic injury are not fully understood. Here, we identify disulfidptosis-a recently d...
The multi-omics landscape of lung adenocarcinoma evolution: deciphering metabolic reprogramming-driven immune escape and its implications in combined therapy [0.03%]
肺癌腺癌演进的多组学景观：代谢重编程驱动免疫逃逸的解析及其在联合治疗中的意义
Na Liu,Guohu Han,Jing Jia et al.
Na Liu et al.
The progression of lung adenocarcinoma (LUAD) from pre-invasive lesions (atypical adenomatous hyperplasia/adenocarcinoma in situ) to invasive adenocarcinoma constitutes a complex, multi-dimensional, and dynamic process. While the genomic dr...
Sustained dysregulation of iron and glutathione homeostasis induces chronoferroptosis, a persistent ferroptotic adaptation in neuronal cells [0.03%]
铁和谷胱甘肽稳态的持续失调诱导神经元细胞发生chronoferroptosis，这是一种持久的铁死亡适应状态
Nawab John Dar,David Soriano-Castell,Pamela Maher
Nawab John Dar
Although iron accumulates in brain regions impacted by neurodegenerative diseases such as Alzheimer's and Parkinson's, how chronic elevated iron levels contribute to neuronal dysfunction remains unclear. Here, we show that sustained iron ov...
Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis [0.03%]
肠道L细胞分泌的新型糖皮质激素诱导型亮氨酸拉链蛋白(GILZ)在溃疡性结肠炎活动期表达异常
Lucrezia Rosati,Giuseppe Leoncini,Luigi Cari et al.
Lucrezia Rosati et al.
The Glucocorticoid-Induced Leucine Zipper (GILZ) is a key mediator of the anti-inflammatory effects of glucocorticoids, primarily within the immune system. Recent evidence has implicated GILZ as a secretive protein in goblet cells, with red...
Fibroblast adipogenesis restricts hemangioma growth through a PPARγ/Hippo-YAP/TAZ axis that promotes endothelial apoptosis and cell cycle arrest [0.03%]
成纤维细胞向脂肪细胞分化通过PPARγ/YAP/TAZ轴促进内皮细胞凋亡及周期阻滞从而限制血管瘤生长
Sheng-Ming Qu,Bing Wang
Sheng-Ming Qu
Infantile hemangioma (HEM) is the most common benign vascular tumor in infancy and is characterized by a unique progression pattern involving rapid proliferation followed by spontaneous involution. Increasing evidence suggests that the tumo...
The IKKα-regulated microRNA miR-9-5p mediates lung cancer growth and invasiveness via CDH1/Wnt/β-catenin signalling [0.03%]
IKKα通过调节microRNA miR-9-5p介导CDH1 / Wnt / β-catenin信号转导从而控制肺癌生长和侵袭性
Simoni Besta,Eugenia Roupakia,Zoi Kanaki et al.
Simoni Besta et al.
IKKα is a serine/threonine kinase that acts as a tumour suppressor in non-small cell lung cancer (NSCLC) in an NF-κΒ-independent manner, however, little is known about its downstream signalling pathways. To interrogate the IKKα signalli...
HAAO‑derived quinolinic acid fuels FDPS‑dependent AR signaling and sensitizes prostate cancer to combination therapy [0.03%]
HAAO衍生的喹啉酸促进FDPS依赖性的AR信号并使前列腺癌对联合治疗敏感化
Hongchang Zhang,Tingting Feng,Mengxue Lv et al.
Hongchang Zhang et al.
Emerging evidence highlights that metabolic reprogramming profoundly shapes the tumor microenvironment and immune evasion in prostate cancer. However, the functional role and mechanisms of tryptophan metabolism in prostate cancer progressio...