Smoking-induced microbial dysbiosis: a key driver of systemic diseases and emerging therapeutic opportunities [0.03%]
吸烟引起的微生物群失调：机体疾病的驱动因素及潜在的治疗机会
Zihao Zhou,Xinyuan Zhao,Shuyu Sun et al.
Zihao Zhou et al.
Tobacco use, including both traditional and electronic cigarettes, profoundly alters host-microbiota interactions, contributing to the pathogenesis of various systemic diseases. Smoking-induced microbial dysbiosis impacts multiple anatomica...
Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms [0.03%]
Prpf4通过不同的机制依次调控红细胞的扩张和成熟
Zhilin Deng,Shuying Huang,Yu Pei et al.
Zhilin Deng et al.
The proliferation of early erythrocyte and the subsequent maturation are critical events during erythropoiesis, while how these two independent but interconnected processes are efficiently orchestrated during erythropoiesis is largely unkno...
IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk [0.03%]
脓毒症中免疫代谢信号互作介导的肺内皮功能障碍及急性肺损伤小鼠模型研究(IL-1β+肺巨噬细胞)
Yang Dong,Tianyuan Li,Bei Fang et al.
Yang Dong et al.
Sepsis-induced acute lung injury (ALI) involves a complex interplay between immune cells and the pulmonary endothelium. However, the molecular regulators that coordinate this interaction remain poorly defined. In a murine sepsis model, we i...
The glycolytic enzyme PFKFB3 alleviates DNA damage and chondrocyte senescence in osteoarthritis [0.03%]
磷酸果糖激酶fb3通过缓解骨关节炎中的DNA损伤和软骨细胞衰老发挥作用
Bo Liu,Chenzhong Wang,Ziyu Weng et al.
Bo Liu et al.
Chondrocyte senescence is a key driver of osteoarthritis (OA) progression. This study examined the role of the glycolytic enzyme PFKFB3 in regulating chondrocyte senescence during OA. Using a destabilization of the medial meniscus (DMM) mou...
CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1 [0.03%]
Circular RNA CircPPFIA2通过海绵作用于miR-646和miR-1200来上调ETS1，从而促进前列腺癌进展和恩杂鲁胺耐药性
Yiyou Mao,Qu Leng,Jun Wu et al.
Yiyou Mao et al.
Prostate cancer (PCa) represents a leading cause of cancer-related morbidity in men worldwide, necessitating deeper insights into its molecular drivers. Circular RNAs (circRNAs) are increasingly recognized as key regulatory molecules in car...
GADD45β inhibits RIPK3-mediated NF-κB activation by interfering with NEMO-RIPK1-RIPK3 interactions [0.03%]
GADD45β通过干扰NEMO-RIPK1-RIPK3相互作用抑制RIPK3介导的NF-κB活化
Carmela Casale,Alete Colella,Miriam Cruoglio et al.
Carmela Casale et al.
Necroptosis is a highly inflammatory form of regulated cell death driven by Receptor-Interacting Protein Kinase 3 (RIPK3), which plays a crucial role in immune responses, inflammatory diseases, and tumor microenvironment modulation. Beyond ...
Niacin inhibits vascular calcification via modulating of SIRT1/SIRT6 signaling pathway [0.03%]
烟酸通过调节SIRT1/SIRT6信号通路抑制血管钙化
Chao-Hua Kong,Li-da Wu,Yue Sun et al.
Chao-Hua Kong et al.
Vascular calcification (VC) is a common pathological state that often accompanies calcium-phosphorus metabolism disorder and chronic kidney diseases (CKDs). Vascular smooth muscle cell (VSMC) has been widely acknowledged as one of the main ...
Hypoxia-triggered autophagy modulates cisplatin resistance in non-small cell lung Cancer via EIF2AK3-dependent PI3K/AKT signaling and mTOR-independent mechanisms [0.03%]
缺氧通过EIF2AK3依赖的PI3K / AKT信号传导和mTOR非依赖性机制触发自噬调节非小细胞肺癌对顺铂的抗性
Jiding Fu,Wei Xu,Ge Wang et al.
Jiding Fu et al.
Chemoresistance in non-small-cell lung cancer (NSCLC) remains a significant clinical challenge, often exacerbated by the tumor microenvironment's hypoxic conditions. Hypoxia has been implicated in promoting autophagy and contributing to che...
O-GlcNAcylation in novel regulated cell death: ferroptosis, pyroptosis, and necroptosis [0.03%]
O-GlcNAc酰化在新型调节性细胞死亡中的作用：铁死亡、焦亡和坏死型细胞死亡
Ying-Zi Wang,Hao-Yu Zhao,Tashi Nyima et al.
Ying-Zi Wang et al.
GlcNAcylation, a dynamic post-translational modification involving the addition of N-acetylglucosamine to serine and threonine residues, has emerged as a key regulatory factor in cellular metabolism and signaling. Ferroptosis, pyroptosis, a...
Exploring p53 isoforms: unraveling heterogeneous p53 tumor suppressor functionality in uveal melanoma [0.03%]
探究p53异构体在脉络膜黑色素瘤中的作用机制研究
Laura Bartolomei,Yari Ciribilli,Samuele Brugnara et al.
Laura Bartolomei et al.
Uveal melanoma (UM) is the most common intraocular tumor, and despite being rare, it accounts for nearly 13% of melanoma-related deaths. Indeed, patients with metastatic disease have typically survival rates of less than one year, with litt...