Chemically induced dimerization of GSDMD C-terminal domain blocks GSDMD N-terminal domain-mediated pyroptosis [0.03%]
化学诱导的GSDMD C端结构域二聚化可抑制GSDMD N端结构域介导的细胞焦亡
Jixuan Xu,Miaoran Fu,Yamin Xing et al.
Jixuan Xu et al.
GSDMD is a pyroptosis executioner in which the C-terminal domain completely inhibits the pore-forming ability of the N-terminal domain. Caspase cleavage separates GSDMD into the free C-terminal fragment (GD-CT) and the free N-terminal fragm...
Apomorphine is a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein oligomerization [0.03%]
阿朴吗啡是一种新型的混合谱系激酶结构域样蛋白聚合抑制剂
Myeonggil Han,Dong-Hyun Seo,Man Sup Kwak et al.
Myeonggil Han et al.
Necroptosis, a form of programmed cell death, has emerged as a promising therapeutic target. Although several RIPK1 inhibitors have demonstrated favorable safety profiles in clinical trials, clinical translation of necroptosis-targeted ther...
Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats [0.03%]
芸香素纳米颗粒改善慢性矛盾式睡眠剥夺引起的认知障碍
Yujie Hu,Dan Hou,Shuling Wang et al.
Yujie Hu et al.
Nobiletin (NOB), a naturally occurring polymethoxyflavonoid, has been shown to regulate the expression of the clock gene BMAL1. This study aims to explore the impact of NOB nanoparticles on microglial polarization and cognitive impairments ...
Glutamine: a new strategy for targeted metabolic therapy in the tumor microenvironment [0.03%]
谷氨酰胺：肿瘤微环境中基于代谢的治疗的新策略
Haixu Lv,Xiao Han,Yuanshuang Yang et al.
Haixu Lv et al.
In the tumor microenvironment, glutamine has a profound impact not only on the growth, metabolism, metastasis, and invasion of tumor cells but also on the survival and function of immune cells and the behavior of nonimmune cells. Given the ...
CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression [0.03%]
基于CRISPR-Cas9的筛选发现G2E3是控制自噬溶酶体融合和癌细胞进展的新泛素连接酶因素
Yumei Gong,Marc Leon,Huaqing Mo et al.
Yumei Gong et al.
Autophagy is a tightly regulated process essential for cellular homeostasis, with ubiquitination playing a crucial role in its regulation. However, the specific ubiquitin related factors involved in autophagic flux remain largely unexplored...
The effect of TIM1+ Breg cells in myocardial ischemia-reperfusion injury [0.03%]
TIM1+Breg细胞在心肌缺血再灌注损伤中的作用
Cong Zeng,Jianchuan Qi,Feifei Wu et al.
Cong Zeng et al.
Recent studies found that treatment with an anti-T-cell immunoglobulin mucin-1 (TIM1) monoclonal antibody (RMT1-10) regulated immune responses by inducing regulatory B cells (Bregs). However, the role of these cells in myocardial ischemia-r...
Harnessing ferroptosis to transform glioblastoma therapy and surmount treatment resistance [0.03%]
利用铁死亡转化胶质母细胞瘤治疗及克服耐药性
Shilpi Singh,Iteeshree Mohapatra,Debashis Barik et al.
Shilpi Singh et al.
Glioblastoma remains the most aggressive and treatment-resistant brain malignancy, driven by genetic heterogeneity, metabolic plasticity, and an immunosuppressive tumor microenvironment (TME). Current therapies rely on inducing tumor cell d...
MiR-140-3p regulates axonal motor protein KIF5A and contributes to axonal transport degeneration in SMA [0.03%]
MiR-140-3p通过调控轴突运动蛋白KIF5A参与脊髓性肌萎缩的轴突运输障碍形成
Markella Baklou,Valeria Valsecchi,Giusy Laudati et al.
Markella Baklou et al.
Spinal muscular atrophy (SMA) is a paediatric neuromuscular disease caused by alterations of the survival motor neuron (SMN) gene, which results in progressive degeneration of motor neurons (MNs). Although effective treatments for SMA patie...
Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stress [0.03%]
靶向ESR1可恢复SQSTM1依赖的自噬并使乳腺癌对氧化和放射应激敏感
Yi-Fang Yang,Zhao-Jing He,Han-Hsi Kuo et al.
Yi-Fang Yang et al.
Estrogen receptor-positive (ER⁺) breast cancer is commonly treated with hormone therapy; however, these tumors frequently develop drug resistance and exhibit poor responses to radiotherapy. To investigate the molecular basis of therapy res...
Insufficient NNMT promotes autophagy and disrupts progesterone signaling in endometrial stromal cells in recurrent implantation failure by modulating the H3K9me3-ALDH1A3 pathway [0.03%]
NNMT不足通过调节H3K9me3-ALDHIA3通路促进内膜间质细胞自噬并破坏孕酮信号引起复发性种植失败
Yifei Song,Shaotong Zhao,Xianping Hou et al.
Yifei Song et al.
Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear. While nicotinamide N-methyltransferase (NNMT) is abundantly expressed in huma...