Silent regulators of trauma: the microRNA blueprint underlying post-traumatic stress disorder biology [0.03%]
沉默的创伤调节者： PTSD生物学中的微小RNA蓝图
Yogesh Dwivedi,Kevin Prall,Richard C Shelton
Yogesh Dwivedi
Post-traumatic stress disorder (PTSD) is a chronic and disabling psychiatric condition that affects millions of people worldwide, producing persistent disturbances in emotional regulation, cognition, and physiological functioning. Although ...
Gene-specific DNA methylation responses to Pb2+ exposure in aged male zebrafish and associations with locomotor dysfunction [0.03%]
暴露于铅离子的斑马鱼基因特异性DNA甲基化反应及与运动功能障碍的相关性研究
Chia-Chen Wu,Danielle N Meyer,Grace A Winny et al.
Chia-Chen Wu et al.
Lead (Pb2+) is a well-established neurotoxin that impairs motor, learning, and memory functions, particularly in children and younger adults. However, its impact on older adults remains less understood. Pb2+ toxicity involves disruption of ...
Effects of RNAi-by-feeding on DNA methyltransferases in Daphnia pulex [0.03%]
RNAi-by-feeding对水蚤(Daphnia pulex)DNA甲基转移酶的影响
Trenton C Agrelius,Krista Harmon,Allison Reed et al.
Trenton C Agrelius et al.
DNA methyltransferases (DNMTs) are well-characterized epigenetic enzymes responsible for transferring methyl groups to and from DNA. Three main DNMT orthologues differ in function and methylation capability. They each are evolutionarily con...
Distinct DNA hydroxymethylation landscape and mitochondrial DNA rearrangement signatures induced by single- and multi-fraction alpha particle radiation in lung fibroblasts [0.03%]
单次和多次α粒子照射对肺成纤维细胞DNA羟甲基化景观及线粒体DNA重排的影响
Marilyn N Vera-Chang,John M Danforth,Marilyne Stuart et al.
Marilyn N Vera-Chang et al.
Alpha (α)-radiation is a genotoxic and epigenotoxic agent capable of increasing the risk of cancer and other diseases. DNA hydroxymethylation (DNAhm) can modulate gene expression and is considered an under-researched epigenetic event in io...
Mechanistic insights into PM2.5-induced cardiac fibrosis involving ERS/TXNIP/NLRP3-driven pyroptosis in multiple cell types [0.03%]
基于多细胞类型的PM2.5诱导心肌纤维化机制研究——ERS/TXNIP/NLRP3介导的焦亡反应作用探究
Siqi Li,Xiaohong Li,Xiaolin Han et al.
Siqi Li et al.
Fine particulate matter (PM2.5) exposure leads to cardiovascular diseases (CVDs) by promoting cardiac fibrosis has been demonstrated. However, the mechanisms by which PM2.5 induces cardiac fibrosis remain unclear. Here, we confirm that the ...
Characterization of long noncoding RNAs, microRNAs, and piwiRNAs in reef-building corals [0.03%]
关于造礁珊瑚长链非编码RNA、微小RNA和piwi-RNA的特征分析
Jill Ashey,Javier A Rodriguez-Casariego,Kathleen M Durkin et al.
Jill Ashey et al.
Noncoding RNAs (ncRNAs) play critical regulatory roles in gene expression regulation that influence diverse biological processes. Yet, their characterization in nonmodel organisms, particularly sessile, benthic ecosystem engineers such as r...
BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells [0.03%]
双酚A诱导鲤鱼生殖细胞和体细胞雄激素受体启动子CpG岛差异甲基化
Anjana Giri,Jayasree Nath,Ramji K Bhandari
Anjana Giri
The androgen receptors (Ar) are fundamental mediators of androgen signaling, critical for male fertility. Environmental endocrine disruptors (EEDs) can impair male fertility; however, it remains unclear whether EED-induced fertility impairm...
Persistent transcriptomic changes following repeated exposure to wood smoke in nonhuman primate airway epithelial cells [0.03%]
反刍类空气道上皮细胞反复接触木烟后的转录组变化的持久性
Evan Holmes,Anthony P Brown,Sweeney P Elston et al.
Evan Holmes et al.
Exposure to wildfire smoke is a significant public health concern with the respiratory system heavily impacted. Wildfire events are increasing in number and severity, and inhalation of wildfire smoke can lead to airway inflammation, oxidati...
Prenatal humid heat exposure and cord blood extracellular vesicle microRNA profiles in a Ghanaian Pregnancy Cohort: GRAPHS [0.03%]
妊娠期孕妇暴露于高湿热环境与胎盘外泌体miRNAs的关系：加纳GRAPHS项目子研究结果
Alison Lee,Seyram Kaali,Michelle Li et al.
Alison Lee et al.
Humid heat exposures over pregnancy impact birth outcomes but mechanisms are poorly described. We leveraged the Ghana Randomized Air Pollution and Health Study (GRAPHS) to examine associations between maximum shaded wet bulb globe temperatu...
DNA methylation mediates the multiple sclerosis onset risk associated with HHV-6 DNA positivity [0.03%]
DNA甲基化介导HHV-6 DNA阳性多发性硬化症发病风险
Alex Eisner,Steve Simpson-Yap,Daniel J Park et al.
Alex Eisner et al.
In Ausimmune, an Australian multicenter incident case-control study, Epstein-Barr virus (EBV)-related measures, including anti-EBNA antibodies and infectious mononucleosis, show multiple sclerosis (MS) associations mediated by DNA methylati...