Shyleen Frost,Kathy Pham,Erica C Heinrich
Shyleen Frost
High altitude presents a significant environmental stressor in the form of hypobaric hypoxia. The body responds to this condition with various acclimatization mechanisms, yet the role of epigenetic modifications, particularly DNA methylatio...
DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities [0.03%]
DNA甲基化作为产前暴露生物标志物的当前挑战和机遇
Rachel B Walkup,Matthew A Nangle,Phillip E Bergmann et al.
Rachel B Walkup et al.
The prenatal environment contributes to the risk for congenital conditions, including birth defects, developmental disorders, and diseases that manifest in later life. However, our current understanding of prenatal exposures and their impac...
Diazinon may increase the risk of acute lymphoblastic leukemia by inducing MGMT promoter methylation [0.03%]
敌敌畏通过诱导MGMT启动子甲基化可能增加急性淋巴细胞白血病的发病风险
Arash Rafeeinia,Mehrnaz Karimi Darabi,Reza Sadeghi et al.
Arash Rafeeinia et al.
Background and objective: Acute lymphoblastic leukemia (ALL) is the most frequent childhood malignancy, which is impacted by genetic, epigenetic, and environmental variables. Aberrant methylation of genes, such as O6-meth...
An exploratory analysis of miRNAs measured in placental tissue and their associations with prenatal exposure to household air pollution [0.03%]
基于胎盘组织中测量的miRNAs对其暴露于家用空气污染的探索性分析
Abigail Gaylord,Mohammed Nuhu Mujtaba,Michelle Li et al.
Abigail Gaylord et al.
Household air pollution (HAP) has been associated with adverse pregnancy and birth outcomes, but the underlying mechanisms remain unclear. Pollutants can cross the placenta, potentially causing dysregulation of the crucial organ. Placental ...
Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood [0.03%]
孕期金属混合物暴露对脐带血DNA甲基化细胞类型组成的影响
Sandra India-Aldana,Hachem Saddiki,Luigi Annicchiarico et al.
Sandra India-Aldana et al.
Metal(loid) exposure can exert immunotoxic effects, including changes in white blood cell proportions. The impact from metal exposure mixtures during pregnancy has not been examined in relation to cell-type composition at birth. Our aim was...
Triphenyl phosphate induces coordinated DNA methylation and gene expression changes in aquatic embryonic cells [0.03%]
三苯基磷酸盐诱导水生胚胎细胞中协同的DNA甲基化和基因表达变化
Logan S Germain,Benjamin P Ott,Charles C T Hindmarch et al.
Logan S Germain et al.
Triphenyl phosphate (TPHP) is a high-production-volume flame retardant and plasticizer that is widely detected in the environment and in biomonitoring studies. TPHP exposure has been linked to endocrine disruption, metabolic disruption, gen...
Michael K Skinner
Michael K Skinner
Preeclampsia and environmental epigenomics: the emerging role of air pollution, gut microbiome, and maternal exposures in disease programming [0.03%]
子痫前期与环境表观基因组学：空气污染、肠道菌群和母体暴露在疾病编程中的作用不容忽视
Geethika Yelleti,Nihaal Maripini,Varashree Bolar Suryakanth
Geethika Yelleti
Preeclampsia (PE) remains a major contributor of maternal and fetal morbidity and mortality worldwide, affecting 2%-8% of pregnancies. While genetic predisposition, placental dysfunction, and angiogenic imbalance remain central to PE pathop...
Sex-dependent biobehavioural responses to transgenerational maternal stress: evidence of stress resilience and vulnerability in the F3 generation [0.03%]
跨代母体压力的性别差异型生物行为反应：F3代压力抵抗与脆弱性的证据
Jamshid Faraji,Nicola Schatz,Stephanie King et al.
Jamshid Faraji et al.
Maternal prenatal stress can determine stress resilience and vulnerability of future generations. However, the extent to which the biological sex of the descendants determines the response to ancestral stress is not fully understood. In thi...
Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations [0.03%]
表观遗传跨世代效应在十代哺乳动物中的稳定传递导致成年期发病
Alexandra A Korolenko,Eric E Nilsson,Sarah De Santos et al.
Alexandra A Korolenko et al.
In traditional models of Drosophila flies and Caenorhabditis elegans worms, epigenetic transgenerational inheritance has persisted for hundreds of generations. Mammalian studies, however, have primarily investigated up to three or four gene...