The Sr-HA-loaded PLGA cage structure combines cells to construct a bone tissue repair unit [0.03%]
负载Sr-HA的PLGA笼状结构结合细胞构建骨组织修复单元
Huixing Yi,Guowen Duan,Siyu Li et al.
Huixing Yi et al.
Osteoporosis arises from an imbalance where bone resorption outpaces formation, reducing bone mass and mineral density while elevating fracture risk. Subsequent surgical repair of these fractures in compromised bone is prone to cause second...
Multifunctional thermosensitive hydrogel for synergistic antibacterial, anti-inflammatory and osteogenic effects to promote periodontal regeneration in periodontitis treatment [0.03%]
一种多功能热敏水凝胶，在牙周炎治疗中用于协同抗菌、抗炎和成骨作用以促进牙周组织再生
Long Wang,Mingxi Wang,Runzi Zhang et al.
Long Wang et al.
Periodontal disease therapy faces complex pathological challenges, including persistent anaerobic bacterial infection, excessive inflammatory activation and impaired alveolar bone regeneration. Monofunctional biomaterials thus fail to meet ...
Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications [0.03%]
工程化丝素水凝胶构象转变以构建用于生物医学应用的高级动态微环境
Xiang Yao,Xueqian Xu,Guolong Cai et al.
Xiang Yao et al.
Among varied silk fibroin (SF) materials, chemically crosslinked SF hydrogels (SFHs) showed excellent biocompatibility and ECM-mimetic property, thus being widely used in biomedical applications. Intriguingly, recent studies have uncovered ...
Piezo1-activated mesenchymal stem cells-derived extracellular matrix hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling [0.03%]
Piezo1激活的间充质干细胞来源的细胞外基质水凝胶通过成骨和血管生成偶联促进骨质疏松性骨缺损修复
Han Yin,Weiqi Zhang,Dongxuan Wei et al.
Han Yin et al.
Osteoporotic bone defects present a significant clinical challenge due to impaired osteogenesis and angiogenesis, often leading to poor healing and bone regeneration. Current therapeutic approaches, including demineralized cancellous bone m...
Mesoporous bioactive glass-recombinant collagen III nanocomposite capsule promotes skin wound healing via adaptive immune modulation [0.03%]
介孔生物活性玻璃-重组胶原III纳米复合胶囊通过适应性免疫调节促进皮肤伤口愈合
Yi Luo,Jian Jin,Wei Ding et al.
Yi Luo et al.
Chronic skin wounds remain a clinical challenge due to impaired extracellular matrix (ECM) reconstruction and dysregulated immune responses. Biomaterials that simultaneously support matrix formation and modulate the wound immune microenviro...
Oxygen-releasing scaffolds in tissue engineering: design strategies, fabrication and regenerative applications [0.03%]
组织工程中释放氧气的支架：设计策略、制造及再生应用
Yuqing Shang,Lele Wang,Huoyun Shen et al.
Yuqing Shang et al.
Oxygen is indispensable for sustaining tissue and cell physiological functions, yet a hypoxic microenvironment often arises in tissue injury and regeneration, impairing graft scaffold performance and hindering repair processes. Thus, oxygen...
Migration of co-cultured endothelial and smooth muscle cells on material surfaces [0.03%]
共培养的内皮细胞和平滑肌细胞在材料表面的迁移行为研究
Runjia Shen,Yanshuang Zhang,Ziyue Zhang et al.
Runjia Shen et al.
Surface endothelialization of a medical device after implantation into the cardiovascular system depends upon competitive migration between endothelial cells (ECs) and smooth muscle cells (SMCs). While both cell types have been extensively ...
Development and translation of biodegradable metal stents: from heart to brain [0.03%]
可降解金属支架的研发与转化：从心脏到血管中枢神经系统肿瘤治疗中的应用
Xiaofeng Cao,Guanjun Chen,Yuchen Fan et al.
Xiaofeng Cao et al.
Biodegradable metal stents offer a promising approach for vascular intervention by providing temporary mechanical support and subsequently degrading once healing is complete. While significant progress has been made in cardiovascular applic...
Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions [0.03%]
基于协同作用的纳米复合水凝胶促进感染条件下的组织再生
Kailing Yu,Jia Zhong,Yilin Ma et al.
Kailing Yu et al.
Impaired tissue regeneration, rather than mere bacterial colonization, represents the core pathological challenge in infected wounds, where persistent infection, biofilm formation and inflammatory dysregulation collectively disrupt the heal...
Integrated platform for EV separation and controlled release based on gelatin microspheres for diabetic wound treatment [0.03%]
一种基于明胶微球的集成平台用于糖尿病伤口治疗中的EV分离和可控释放
Yiqing Zhang,Qilin Huang,Hao Meng et al.
Yiqing Zhang et al.
Diabetic wounds exhibit impaired healing owing to multiple pathological factors and current treatment options remain limited, underscoring the urgent need for novel therapeutic strategies. Extracellular vesicles (EVs) derived from mesenchym...