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Piezo1-activated mesenchymal stem cells-derived extracellular matrix hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling

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Osteoporotic bone defects present a significant clinical challenge due to impaired osteogenesis and angiogenesis, often leading to poor healing and bone regeneration. Current therapeutic approaches, including demineralized cancellous bone matrix and synthetic ... ...