An injectable self-healing curcumin-sustained-release hydrogel for lower limb ischemia via autophagy inhibition by Atp6v0d2 downregulation [0.03%]
通过下调Atp6v0d2抑制自噬的可注射自愈性姜黄素缓释水凝胶治疗下肢缺血
Hanfei Tang,Fang Wang,Tonglei Han et al.
Hanfei Tang et al.
Although hydrophobic drugs demonstrate the promising therapeutic efficacy for peripheral artery disease in vitro, their in vivo performance is often hindered by low bioavailability due to inherent hydrophobicity. To address this, an injecta...
Injectable Mn-Icariin-functionalized silk fibroin/PEG hydrogels restore redox homeostasis and reprogram osteogenic-angiogenic coupling for diabetic bone regeneration [0.03%]
可注射Mn-Icariin功能化丝素/PEG水凝胶恢复氧化还原稳态并重新编程成骨-血管生成偶联以实现糖尿病骨组织再生
Yukai Huang,Shihao Zhang,Xiaogang Zhou et al.
Yukai Huang et al.
Bone defect repair under hyperglycemic conditions is limited by sustained oxidative stress, chronic low-grade inflammation and disrupted osteoimmune-vascular coupling. In this study, we constructed an injectable and biodegradable silk fibro...
Ginseng-derived exosomes loaded in fibrin gel promote retinal ganglion cell survival in glaucoma by exerting anti-inflammatory effects through modulating microglial polarization [0.03%]
人参源外泌体负载纤维蛋白凝胶通过调节小胶质细胞极化发挥抗炎作用促进青光眼视网膜神经节细胞存活
Dengming Zhou,Dehong Tan,Xuanqi Peng et al.
Dengming Zhou et al.
Glaucoma is the leading cause of irreversible blindness globally. Chronic neuroinflammation drives progressive retinal ganglion cell (RGC) loss independent of intraocular pressure, yet safe, sustained and precise neuroprotective modulation ...
Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials [0.03%]
巨噬细胞的序贯极化：用于新型骨修复材料的免疫调控策略
Xueqin Gao,Shuao Dong,Xiyue Zheng et al.
Xueqin Gao et al.
Within the biomaterial-constructed bone repair microenvironment, intricate crosstalk among immune, osteogenic and vascular cells is essential for maintaining local osteoimmune homeostasis and driving tissue regeneration. Macrophages act as ...
Yi Zhang,Zhen Huang,Beichen Wang et al.
Yi Zhang et al.
Three-dimensional (3D) bioprinting enables the precise fabrication of complex tissue constructs by depositing living cells, biomaterials, and bioactive factors in a spatially controlled manner. Concurrently, organoids-self-organizing 3D cel...
Advanced lyophilized mesenchymal stem cell-conditioned medium formulation improves therapeutic efficacy in skin wound repair [0.03%]
改良的间充质干细胞条件培养基冻干粉联合人工真皮促进难愈创面修复效力增强
Xinjiani Chen,Bailei Li,Wenxue Gu et al.
Xinjiani Chen et al.
The secretome of human umbilical cord mesenchymal stem cells (hUC-MSCs) represents a promising cell-free therapeutic approach for wound healing because of its rich composition of bioactive factors that promote tissue repair. However, the cl...
Biofluid-derived exosomes as next-generation biotherapeutic platforms to combat multidrug-resistant bacterial infections [0.03%]
用于对抗多重耐药细菌感染的生物液源外泌体新一代生物治疗平台
Anqi Liu,Haohang Xu,Yongfang Wang et al.
Anqi Liu et al.
Bacterial infections pose a pervasive and escalating global health threat, exacerbated by the relentless emergence of multidrug-resistant pathogens. This crisis demands innovative therapeutic strategies that transcend traditional antibiotic...
Engineering a cell wall-deficient protoplast-incorporated hydrogel for infected wound healing [0.03%]
工程化细胞壁缺陷的原生质体掺入水凝胶用于感染伤口修复
Yan Zeng,Weichao Ding,Xiaohan Zhou et al.
Yan Zeng et al.
Bacteria-infected wounds remain a major clinical challenge due to persistent infection, impaired tissue regeneration and the increasing prevalence of antibiotic resistance. Conventional antibiotic therapies primarily rely on biochemical bac...
Biomimetic M2 microglia membrane-coated nanoplatform for immune reprogramming and targeted edaravone delivery in ischemic stroke [0.03%]
模拟M2型小胶质细胞膜的纳米递药系统用于缺血性脑卒中的免疫调控及依达拉奉靶向递送
Yanhong Ren,Peilong Li,Jiaping Li et al.
Yanhong Ren et al.
Ischemic stroke is a major cause of death and long-term disability worldwide, in which oxidative stress and neuroinflammation contribute substantially to secondary neuronal injury. Edaravone (EDA), a clinically approved free radical scaveng...
Black phosphorus-loaded mineralized UV-responsive chitosan hydrogel for enhanced osteogenesis and antibacterial activity [0.03%]
负载黑磷的矿化型UV响应壳聚糖水凝胶促进骨再生及抗菌性能增强
Xiaoying Xu,Xiaofeng Yang,Tiantian Gao et al.
Xiaoying Xu et al.
Favorable osteogenesis and effective antibacterial activity are two essential requirements for ideal scaffolds in bone tissue engineering, particularly for infected bone defects. Herein, we developed a novel hydrogel system based on mineral...