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Injectable Mn-Icariin-functionalized silk fibroin/PEG hydrogels restore redox homeostasis and reprogram osteogenic-angiogenic coupling for diabetic bone regeneration

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Bone defect repair under hyperglycemic conditions is limited by sustained oxidative stress, chronic low-grade inflammation and disrupted osteoimmune-vascular coupling. In this study, we constructed an injectable and biodegradable silk fibroin/PEG hydrogel inco... ...