The national and provincial disease and indirect economic burden of high alcohol use in China from 1990 to 2023 with forecasting to 2050 [0.03%]
1990年到2023年中国饮酒相关的疾病和间接经济负担及未来至2050年的预测结果
Yang Yang,Da-Chuang Zhou,Zhen-Ping Zhao et al.
Yang Yang et al.
Background: High alcohol use, defined as consumption exceeding the theoretical minimum risk exposure level, poses a major public health challenge in China, yet comprehensive long-term estimates combining disease burden an...
The disease burden attributable to tobacco use in China and its provinces from 1990-2023: an analysis from the Global Burden of Disease Study 2023 [0.03%]
1990年至2023年中国及各省份吸烟归因疾病负担——全球疾病负担研究（2023）结果分析
Ling-Ling Yu,Fan-Shu Yan,Jin-Lei Qi et al.
Ling-Ling Yu et al.
Background: As the world's leading producer and consumer of tobacco, China bears a significant health burden attributable to tobacco. This study aims to provide a precise, updated analysis of the demographic, temporal, an...
The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy [0.03%]
肿瘤微环境在放射性药物治疗中的作用：连接核医学和癌症免疫疗法
Zhi-Peng Wang,Ai-Qing Li,Dilinaer Wusiman et al.
Zhi-Peng Wang et al.
Radiopharmaceutical therapy (RPT) is a pivotal modality in cancer treatment, with its efficacy substantially modulated by the tumor microenvironment (TME). The TME regulates RPT penetration and influences therapeutic outcomes. Concurrently,...
The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism [0.03%]
糖皮质激素在糖脂代谢中的作用、机制及治疗意义
Qiu-Yu Xu,Jie Zhang,Xin-Jian Wan et al.
Qiu-Yu Xu et al.
Glucocorticoids (GCs), steroid hormones synthesized and secreted by the adrenal cortex, have been the subject of intensive scientific investigation for over eight decades due to their critical roles in physiological and pathological process...
Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer [0.03%]
靶向瘤内细菌可逆转MHC-I抑制作用并增强基于纳米技术的化疗免疫治疗在结直肠癌中的疗效
Jing Feng,Yan-Hong Liu,Li-Ming Gong et al.
Jing Feng et al.
Background: Emerging evidence indicates that diverse bacteria colonize tumors and facilitate oncogenesis through multifaceted mechanisms, predominantly through immunosuppression of the tumor microenvironment (TME). Fusoba...
Zhi-Hao Wei,Zi-Rui Dong,An-Shu Li et al.
Zhi-Hao Wei et al.
Circadian rhythms play a critical role in regulating physiological and behavioral processes, such as the sleep-wake cycle, hormone secretion, and metabolism. These rhythms are controlled by endogenous biological clocks, which are synchroniz...
Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders [0.03%]
丘脑中央中核在神经病理性疼痛相关睡眠障碍中的适应不良性重构作用机制研究
Li Li,Qi Han,Hao-Lei Bai et al.
Li Li et al.
Duan Lu Hou,Josephine Ho,Tuchen Guan et al.
Duan Lu Hou et al.
Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss and proteostatic failure, driven by impaired clearance of misfolded proteins via the ubiquitin-proteasome system (UPS) and autophagy. In UPS, E3 ubiquitin ligas...