Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies [0.03%]
创伤后应激障碍的发病机制、流行病学特征、动物模型及潜在治疗策略
Faith Nguyen,Ashok K Shetty
Faith Nguyen
Post-traumatic stress disorder (PTSD) is a complex neurobehavioral disorder that disproportionately affects military service members. The clinical presentation of PTSD is heterogeneous and may overlap with other psychiatric conditions. Acco...
USP18 exacerbates myocardial I/R injury by inhibiting Parkin mitophagy through the deubiquitinase PTEN-L [0.03%]
USP18通过去泛素酶PTEN-L抑制Parkin线粒体自噬从而加重心肌缺血再灌注损伤
Qing-Qing Wu,Yang Xiao,Ying-Ying Hu et al.
Qing-Qing Wu et al.
Background: Mitochondrial quality control is essential for limiting myocardial injury induced by ischemia/reperfusion (I/R), a major contributor to adverse outcomes after reperfusion therapy. This study aimed to determine...
tDCS improves early Alzheimer's disease by synaptic vesicle fusion and release [0.03%]
经颅直流电刺激通过突触小泡融合和释放改善早老性痴呆病症
Yue-Yang Zhuang,Jia-Min Yan,Tie-Cheng Wu et al.
Yue-Yang Zhuang et al.
Background: Working memory deficits, one of the earliest hallmarks of Alzheimer's disease (AD), are closely linked to abnormal neural activity in the dorsolateral prefrontal cortex (DLPFC). Transcranial direct current sti...
3D bioprinting of tissues and organs for systemic diseases and localized injuries [0.03%]
三维生物打印技术在系统性疾病和局部损伤中的应用
Wei Long Ng,Paulo Bartolo
Wei Long Ng
Three-dimensional (3D) bioprinting integrates engineering, materials science, and biology to fabricate living tissues with precise spatial control. By enabling the layer-by-layer deposition of cells and biomaterials, it overcomes many limit...
Pathophysiology-guided biomarkers and therapeutics for precision trauma medicine in polytrauma with musculoskeletal injuries [0.03%]
损伤病理生理指导的生物标志物和靶向药物在多发伤骨筋膜室综合征中的精准医疗作用
Rex Jeya Rajkumar Samdavid Thanapaul,Manoj Y Govindarajulu,Chetan Y Pundkar et al.
Rex Jeya Rajkumar Samdavid Thanapaul et al.
Polytrauma with predominant musculoskeletal (MSK) injury, resulting from blast, blunt, and crush mechanisms, remains a leading and complex challenge in both military and civilian medicine. These injuries not only disrupt tissues structurall...
Antibacterial efficacy of a chitosan-based hydrogel loaded with epsilon poly-L-lysine and poly(I:C) extracellular vesicles for the control of polymicrobial extremity wound infections in a porcine polytrauma model [0.03%]
一种载有ε聚-L-赖氨酸和poly(I:C)外泌体的壳聚糖基水凝胶控制复合感染肢体伤口感染的抗菌效果：猪多发伤模型中的研究
Cole E Ogrydziak,Catherine F T Uyehara,Lee-Ann M Murata et al.
Cole E Ogrydziak et al.
Noor Obaidi,Olivia Agee,Irene Yau et al.
Noor Obaidi et al.
From cold-weather training to deployments in high altitude and arctic conditions, frostbite injury and its sequelae remain a serious concern in military operations. Frostbite harms tissue in two distinct ways. The first involves ice crystal...
The cellular response capacity (CRC) as a novel immunomonitoring approach in sepsis [0.03%]
细胞反应容量(CRC)在脓毒症免疫监测中的应用是一项新颖的免疫检测方法
David Alexander Christian Messerer,Paul Müller,Lisa Wohlgemuth et al.
David Alexander Christian Messerer et al.
Background: Early recognition of sepsis remains difficult in clinical practice because conventional humoral biomarkers such as C-reactive protein, procalcitonin, and interleukin-6 (IL-6) exhibit unfavorable, slow-release ...
Prioritizing human-AI collaboration in healthcare: the TRIAD framework for trustworthy governance, real-world, and integrated adaptive deployment [0.03%]
医疗保健中的人工智能合作优先级：值得信赖的治理、现实世界和集成自适应部署的TRIAD框架
Jia Li,Zi-Chun Zhou,Zhen-Chang Wang et al.
Jia Li et al.
Artificial intelligence (AI) and big data are reshaping the healthcare landscape. However, clinical value depends on how well systems augment clinicians and fit into routine workflows. To this end, we introduce the TRIAD framework: trustwor...
Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis [0.03%]
化腐朽为神奇——让有害抗体转变为治疗脓毒症和类风湿关节炎的良药
Wei-Qiang Chen,Li Lou,Xiao-Ling Qiang et al.
Wei-Qiang Chen et al.
Background: Sepsis and rheumatoid arthritis (RA) are distinct yet mechanistically related conditions commonly driven by dysregulated inflammatory responses. Here, we explored the counterintuitive hypothesis that an epitop...