The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism [0.03%]
糖皮质激素在糖脂代谢中的作用、机制及治疗意义
Qiu-Yu Xu,Jie Zhang,Xin-Jian Wan et al.
Qiu-Yu Xu et al.
Glucocorticoids (GCs), steroid hormones synthesized and secreted by the adrenal cortex, have been the subject of intensive scientific investigation for over eight decades due to their critical roles in physiological and pathological process...
Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer [0.03%]
靶向瘤内细菌可逆转MHC-I抑制作用并增强基于纳米技术的化疗免疫治疗在结直肠癌中的疗效
Jing Feng,Yan-Hong Liu,Li-Ming Gong et al.
Jing Feng et al.
Background: Emerging evidence indicates that diverse bacteria colonize tumors and facilitate oncogenesis through multifaceted mechanisms, predominantly through immunosuppression of the tumor microenvironment (TME). Fusoba...
Zhi-Hao Wei,Zi-Rui Dong,An-Shu Li et al.
Zhi-Hao Wei et al.
Circadian rhythms play a critical role in regulating physiological and behavioral processes, such as the sleep-wake cycle, hormone secretion, and metabolism. These rhythms are controlled by endogenous biological clocks, which are synchroniz...
Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders [0.03%]
丘脑中央中核在神经病理性疼痛相关睡眠障碍中的适应不良性重构作用机制研究
Li Li,Qi Han,Hao-Lei Bai et al.
Li Li et al.
Duan Lu Hou,Josephine Ho,Tuchen Guan et al.
Duan Lu Hou et al.
Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss and proteostatic failure, driven by impaired clearance of misfolded proteins via the ubiquitin-proteasome system (UPS) and autophagy. In UPS, E3 ubiquitin ligas...
Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity [0.03%]
受章鱼启发的工程细菌具有即插即用表面展示系统可实现肿瘤特异性定植和抗肿瘤免疫增强
Le-Yang Wu,Jia-Hui Qiu,Xin-Yue Qiao et al.
Le-Yang Wu et al.
Background: Bacteria-mediated cancer therapy leverages bacteria to modulate the tumor immune microenvironment and deliver therapeutics. However, its clinical application is limited by toxicity, off-target effects, and unc...
Burden of women's cancers in the group of twenty (G20) from 1990 to 2023: epidemiological trends and impact from fertility, quality of care, and survival [0.03%]
1990年至2023年二十国集团（G20）女性癌症负担：流行病学趋势及生育率、护理质量和生存率的影响
Meng-Long Li,Rui-Shu Tang,Nan Wang et al.
Meng-Long Li et al.
Background: Cancer in women represents a significant disease burden, posing challenges for prevention, treatment, and caregiving. This study aimed to analyze the epidemiological trends of the women's cancer burden and the...
Huai-Dong Du
Huai-Dong Du
Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies [0.03%]
代谢综合征与脓毒症及脓毒症相关死亡风险的关系：两项大型前瞻性队列研究的证据
Shao-Yu Liu,Shao-Kang Xu,Jing-Li Gao et al.
Shao-Yu Liu et al.
Background: Metabolic syndrome (MetS) is characterized by chronic low-grade inflammation and immune dysregulation, which may increase susceptibility to sepsis. However, epidemiologic evidence remains limited. This study a...