Jiansheng Jiang,Kannan Natarajan,David H Margulies
Jiansheng Jiang
This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for recognition by receptors on T lymphocytes (T cel...
Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity [0.03%]
人肽精氨脱亚胺酶VI(PAD6)的晶体结构及其无活性的原因解析
Fanomezana M Ranaivoson,Rieke Bande,Isabell Cardaun et al.
Fanomezana M Ranaivoson et al.
Human peptidylarginine deiminase isoform VI (PAD6), which is predominantly limited to cytoplasmic lattices in the mammalian oocytes in ovarian tissue, is essential for female fertility. It belongs to the peptidylarginine deiminase (PAD) enz...
Time-series analysis of rhenium(I) organometallic covalent binding to a model protein for drug development [0.03%]
时间序列分析铼(I)有机金属共价结合模型蛋白用于药物开发
Francois J F Jacobs,John R Helliwell,Alice Brink
Francois J F Jacobs
Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions betwee...
Linking solid-state phenomena via energy differences in `archetype crystal structures' [0.03%]
通过典型晶体结构中的能量差异建立固态现象之间的联系
B Dittrich,L E Connor,F P A Fabbiani et al.
B Dittrich et al.
Categorization underlies understanding. Conceptualizing solid-state structures of organic molecules with `archetype crystal structures' bridges established categories of disorder, polymorphism and solid solutions and is herein extended to s...
Nanostructure and dynamics of N-truncated copper amyloid-β peptides from advanced X-ray absorption fine structure [0.03%]
基于先进X射线吸收精细结构的N端截短铜离子结合淀粉样蛋白-β肽纳米结构与动力学研究
Ruwini S K Ekanayake,Victor A Streltsov,Stephen P Best et al.
Ruwini S K Ekanayake et al.
An X-ray absorption spectroscopy (XAS) electrochemical cell was used to collect high-quality XAS measurements of N-truncated Cu:amyloid-β (Cu:Aβ) samples under near-physiological conditions. N-truncated Cu:Aβ peptide complexes contribute...
RCSB Protein Data Bank: supporting research and education worldwide through explorations of experimentally determined and computationally predicted atomic level 3D biostructures [0.03%]
RCSB蛋白质数据中心：通过实验测定和计算预测的原子水平三维生物结构的研究与教育支持全球研究与教育
Stephen K Burley,Dennis W Piehl,Brinda Vallat et al.
Stephen K Burley et al.
The Protein Data Bank (PDB) was established as the first open-access digital data resource in biology and medicine in 1971 with seven X-ray crystal structures of proteins. Today, the PDB houses >210 000 experimentally determined, atomic lev...
The ABC toxin complex from Yersinia entomophaga can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo [0.03%]
耶尔森菌昆虫致病亚种ABC毒蛋白复合体能将三个不同的细胞毒性成分从不同遗传位置以无序状态包装：外壳和有效成分的结构研究
Jason N Busby,Sarah Trevelyan,Cassandra L Pegg et al.
Jason N Busby et al.
Bacterial ABC toxin complexes (Tcs) comprise three core proteins: TcA, TcB and TcC. The TcA protein forms a pentameric assembly that attaches to the surface of target cells and penetrates the cell membrane. The TcB and TcC proteins assemble...
Barbara Olech,Petr Brázda,Lukas Palatinus et al.
Barbara Olech et al.
Dynamical refinement is a well established method for refining crystal structures against 3D electron diffraction (ED) data and its benefits have been discussed in the literature [Palatinus, Petříček & Corrêa, (2015). Acta Cryst. A71, 2...
Structural dissection of two redox proteins from the shipworm symbiont Teredinibacter turnerae [0.03%]
Shipworm symbiont Teredinibacter turnerae的两种氧化还原蛋白的结构分析
Badri S Rajagopal,Nick Yates,Jake Smith et al.
Badri S Rajagopal et al.
The discovery of lytic polysaccharide monooxygenases (LPMOs), a family of copper-dependent enzymes that play a major role in polysaccharide degradation, has revealed the importance of oxidoreductases in the biological utilization of biomass...
Transferable Hirshfeld atom model for rapid evaluation of aspherical atomic form factors [0.03%]
可转移的Hirshfeld原子模型用于快速评估非球形原子形式因子
Michał Chodkiewicz,Leonid Patrikeev,Sylwia Pawlędzio et al.
Michał Chodkiewicz et al.
Form factors based on aspherical models of atomic electron density have brought great improvement in the accuracies of hydrogen atom parameters derived from X-ray crystal structure refinement. Today, two main groups of such models are avail...