Scalable synthesis of asymmetric hemodialysis membranes to enhance performance and biocompatibility in flat sheet and hollow fiber configurations [0.03%]
一种可扩展合成不对称血液透析膜的方法，可在平板和中空丝构型下提升性能和生物相容性
Aniza Nasir,Abdul Waseh,Tahir Ahmad et al.
Aniza Nasir et al.
Hemodialysis is indispensable for patients with end-stage renal disease (ESRD). Yet, the performance of conventional polymeric membranes is restricted by protein adsorption, poor hemocompatibility, and thrombo-inflammatory responses. We hyp...
Based on multi-pathway induction of tumor immunogenic death and three-mode highly integrated strategy: a nanocomposite system loaded with irinotecan for colorectal cancer therapy [0.03%]
基于多通路诱导肿瘤免疫原性死亡及三模式高度整合策略的载伊立替康纳米复合系统用于结直肠癌治疗
Xing Lei,Ya Wang,Xiaojiang Zhang et al.
Xing Lei et al.
Irinotecan (CPT-11), a first-line chemotherapeutic agent for colorectal cancer, faces challenges like tumor drug resistance and severe toxicities such as neutropenia and diarrhea. Current nanocarriers for CPT-11 have limitations in achievin...
Supramolecular eutectogel based on THDESs as a skin penetrating carrier for effective transdermal delivery of hydrophobic drug curcumin [0.03%]
基于THDES的超分子共晶凝胶作为经皮给药载体促进疏水性药物姜黄素的有效透皮递送研究
Nildhara Parsana,Priyam Patel,Hiral Ukani et al.
Nildhara Parsana et al.
Therapeutic hydrophobic deep eutectic solvents (THDESs) are an emerging class of eutectic mixtures gaining significant attention in the biomedical field. Solidifying these THDESs into bioactive eutectogels broadens their application in tran...
Shark skin-inspired PDA-coated and peptide-functionalized wrinkled chitosan/gelatin microspheres for hemostasis and infected wound healing [0.03%]
灵感来源于鲨鱼皮的PDA包被和肽功能化的皱缩壳聚糖/明胶微球促进止血和感染伤口愈合
Wei Guo,Yuwei Hsu,Ye Zhang et al.
Wei Guo et al.
Severe hemorrhage and its associated complications represent the primary causes of mortality among trauma patients. Consequently, the development of hemostatic materials that exhibit rapid and effective hemostatic properties, alongside favo...
L-DNA-based probes for the detection of radiation-induced DNA strand cleavage [0.03%]
基于L-DNA的探针用于检测辐射诱导DNA链断裂
Ryanne N Ehrman,Wenrui Zhong,Rosemarie Elloisa P Acero et al.
Ryanne N Ehrman et al.
Accurate assessment of DNA strand breaks is essential for evaluating the efficacy of radiation therapy, yet most existing methods rely on indirect detection of reactive oxygen species (ROS), which are unreliable in hypoxic tumor environment...
Engineered microbial sensors: providing a new paradigm for disease detection [0.03%]
工程化的微生物传感器：疾病检测新模式
Xuan-Ren Shi,Yi-Fan Zhang,Ying Zhou et al.
Xuan-Ren Shi et al.
Microorganisms can be programmed into engineered microbial sensors (EMSs) capable of responding to disease biomarkers. Compared to traditional diagnostics, EMSs exhibit superior advantages in cost-effectiveness, environmental adaptability, ...
Treating rheumatoid arthritis using fibroblast-activated protein-α-responsive micelles through a cascade control program [0.03%]
基于级联调控程序的纤维母细胞活化蛋白-α响应性纳米胶束治疗类风湿关节炎
Yu Li,Pei Xie,Ruixin Gong et al.
Yu Li et al.
Rheumatoid arthritis (RA), a chronic autoimmune disorder affecting 1% globally, urgently demands advanced therapies to overcome the systemic toxicity and limited efficacy of conventional glucocorticoids like dexamethasone (Dex). In this stu...
Bioactive wet adhesive materials for oral health: strategies and applications [0.03%]
用于口腔健康的生物活性湿粘附材料：策略和应用
Geyuan Wang,Yuting Zhou,Xinyi He et al.
Geyuan Wang et al.
The oral cavity represents a unique and complex anatomical environment characterized by its moist and dynamic nature. This environment is crucial for numerous physiological functions, including digestion, respiration, and phonation, while a...
3D printable hydrogel inks with metal-organic frameworks for sustained small drug delivery in wound healing [0.03%]
用于伤口愈合的基于金属有机骨架的水凝胶药物缓释3D打印墨水研究
Youbin Park,Subin Jin,Se-Na Kim et al.
Youbin Park et al.
Wound healing is a complex and dynamic biological process, and impaired healing can lead to prolonged recovery and increased healthcare costs. Recent advancements in wound healing therapeutics include hydrogel-based biomaterials, nanocarrie...
Savinase-functionalised oxidative drug-loaded nanocarriers enhance the treatment of solid colorectal tumours in a 3D cell culture model [0.03%]
一种三维细胞培养模型：装载药物的辛辛那司酶功能化氧化纳米载体能提高实体结直肠肿瘤的治疗效果
Anel G Mun,Nuriya Nurlankyzy,Saule Kalmagambetova et al.
Anel G Mun et al.
Colorectal cancer (CRC) mutations drive resistance and poor prognosis, underscoring the need for more effective therapies. The oxidative drug therapy combining arsenic trioxide (ATO) and D-vitamin C (D-VC) has demonstrated promising efficac...