Harnessing light and ultrasonic vibration: efficient amphiphilic phthalocyanine-based sensitizers for combined sono-photodynamic therapy of breast cancer [0.03%]
结合声动力光动力乳腺癌联合治疗的高效两亲性酞菁敏化剂
Hilal Çakmak,Aysegul Turkkol,Göknur Yaşa Atmaca et al.
Hilal Çakmak et al.
The heterogeneity and global burden of breast cancer necessitate novel therapeutic strategies to circumvent resistance and mitigate systemic toxicity. Amphiphilic phthalocyanines have emerged as highly effective photosensitizers in photodyn...
Insights into Schiff-base crosslinking in chitosan porous scaffolds: the role of dialdehyde polysaccharide ionic nature and bioactive functionalization [0.03%]
席夫碱交联的壳聚糖多孔支架的见解：二醛多糖离子性质和生物活性官能团化的作用
Szymon Salagierski,Weronika Gura,Barbara Zagrajczuk et al.
Szymon Salagierski et al.
This study introduces a systematic framework for fabricating chitosan porous scaffolds using five green dialdehyde polysaccharides (DAPs: chitosan, dextran, gellan, xanthan, and furcellaran) as sustainable click-chemistry-inspired crosslink...
Fabrication of a 3D-printed bioadhesive patch containing engineered IGF-1-secreting cells for the treatment of liver bleeding and diabetic wounds [0.03%]
一种用于治疗肝脏出血和糖尿病伤口的含工程化胰岛素样生长因子1分泌细胞的3D打印生物粘附贴片的制备方法
Durba Banerjee,Snehasish Mandal,Payal Ishwar et al.
Durba Banerjee et al.
Adhesive hydrogel patches with robust mechanical integrity and strong tissue adhesion are crucial for effective wound healing, particularly in moist and dynamic wound environments. Natural polymers have the potential to serve as suitable ma...
PET-RAFT polymerization of redox-responsive lipoic acid-derived cationic polymers: influence of hydrophobicity and degree of polymerization on antimicrobial activity [0.03%]
基于红氧响应型衍生化聚左旋亚叶酸正离子聚合物的PET-RAFT聚合：疏水性与聚合度对抑菌活性的影响
Anupama Giri,Md Aquib,Vinod Kumar Kannaujiya et al.
Anupama Giri et al.
Antimicrobial polymers are increasingly recognized as effective agents against a broad spectrum of microorganisms, including bacteria, fungi, and viruses. Their performance is largely determined by macromolecular topology, molecular weight,...
Winning the 'race for the surface': curcumin-loaded PEDOT coatings with enhanced biocompatibility and antibacterial capabilities [0.03%]
胜过“表面竞赛”：“携带(cur)聚物PEDOT涂层的生物相容性和抗菌性增强型基底表面”的构建与评估
Szymon Smołka,Alicja Tomasiak,Sara Shakibania et al.
Szymon Smołka et al.
The continued growth of bioelectronics has created a pressing demand for the development of implant coatings that integrate balanced electrochemical performance, surface characteristics favouring cell adhesion, excellent biocompatibility, a...
Acoustically active poly(t BMA) floral nanocages for ultrasound-guided spatiotemporal cargo release [0.03%]
声学活性聚(tBMA)花卉型纳米笼载药体系用于超声引导的按需释放药剂
Neerav Sreekumar,Sunil Vasu,Uday Kumar S
Neerav Sreekumar
Clinically approved ultrasound contrast agents, including microbubbles and nanobubbles, suffer from limited circulation stability, restricted extravasation, and dependence on exogenous gas cores, necessitating structurally inherent cavitati...
A mitochondria targeting aggregation-induced emission phototheranostic agent for photodynamic synergistic therapy of triple-negative breast cancer [0.03%]
一种线粒体靶向聚集诱导发光光诊疗试剂用于三阴性乳腺癌光动力协同治疗
Xinhui Zhai,Yifan Liu,Yazixuan Feng et al.
Xinhui Zhai et al.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by poor prognosis and high mortality. However, current treatment options remain inadequate, necessitating the urgent development of novel, m...
Charred Schizonepetae Herba-derived carbon dot crosslinked glycyrrhizic acid hydrogel accelerated hemostasis, anti-inflammation and re-epithelialization for different tissue regeneration [0.03%]
炭化荆芥穗提取物衍生的碳点交联甘草酸水凝胶促进止血、抗炎和上皮再生修复用于不同组织再生
Mijia Zhang,Yixuan Wang,Tao Ye et al.
Mijia Zhang et al.
Surgical suturing remains largely ineffective for severe trauma with uncontrolled bleeding, primarily due to the technical challenges of emergency wound closure and the high risk of postoperative infection. Although medicinal and edible hom...
A glucose-triggered cascade catalytic adhesive hydrogel enables mild photothermal-biofilm eradication for infected diabetic wounds [0.03%]
一种葡萄糖触发的级联催化性粘附水凝胶 enabling 轻度光热-生物膜消除用于感染的糖尿病伤口治疗方法
Xiang Li,Haiqin Tang,Zhiyun Dong et al.
Xiang Li et al.
Delayed healing in chronic diabetic wounds is primarily driven by the hyperglycemic microenvironment and persistent bacterial biofilm infection, making biofilm eradication under mild therapeutic conditions highly challenging. Herein, we des...
Magdalena Osial,Paulina Pietrzyk-Thel,Jakub Hilus et al.
Magdalena Osial et al.
Nanoparticles (NPs) based on holmium or holmium-doped have attracted increasing attention in biomedicine, addressing the needs in cancer diagnostics and therapy due to their unique magnetic and optical properties. However, there are only a ...