From neural stem cells to cell-free exosome nanotherapy: reprogramming the injured spinal cord microenvironment for regeneration [0.03%]
从神经干细胞到不含细胞的外泌体纳米治疗：重新编程损伤脊髓微环境以促进再生
Cheng Zhang,Xiaoyin Liu,Bolin Zhao et al.
Cheng Zhang et al.
Spinal cord injury (SCI) is a severely disabling neurological disorder caused by primary mechanical trauma and subsequent secondary damage, resulting in persistent neurological deficits and imposing a significant social and economic burden....
Endoplasmic reticulum-targeted gold nanorod for chemo-photothermal therapy induces ER stress-mediated autophagy and apoptosis in cancer cells [0.03%]
一种针对内质网的金纳米棒用于诱导癌细胞内质网应激介导的细胞自噬和凋亡的化疗与光热疗法
Asima Sahu,Dipannita Chowdhury,Sudipta Basu
Asima Sahu
Organelle-targeted nanomedicine offers new opportunities for improving cancer therapy. The endoplasmic reticulum (ER), a central regulator of protein folding and cellular stress signaling, has emerged as a promising intracellular target for...
Tumor microenvironment-adaptive nanocatalysts: harnessing pH gradients for selective and synergistic cancer therapy [0.03%]
具有适应肿瘤微环境纳米催化剂的性质：利用pH梯度进行选择性和协同性癌症治疗
Zhiming Deng,Cuiyan Yan,Chen Xie et al.
Zhiming Deng et al.
Malignant tumors represent a major threat to human health, underscoring an urgent need for the development of innovative therapeutic strategies. Tumor catalytic therapy has emerged as a promising approach that leverages the acidic tumor mic...
Hydrogel degradation products as immunomodulatory cues in neural injury: mechanisms and implications for neural repair [0.03%]
水凝胶降解产物作为神经损伤中免疫调节信号的作用机制及其在神经修复中的影响
Jugal Kishore,Fynn S Owen La Boucan,Mohammad Foad Abazari et al.
Jugal Kishore et al.
Neural tissue engineering often uses hydrogels due to their tunable biophysical properties and biocompatibility. While much attention has been devoted to hydrogel mechanics and degradation kinetics, the role of hydrogel degradation byproduc...
Multimodal health monitoring and theranostics based on functionalized hydrogels and artificial intelligence [0.03%]
基于功能化水凝胶和人工智能的多模态健康监测与诊疗技术
Tingyu Sun,Shilong Liu,Kun Qian et al.
Tingyu Sun et al.
Functionalized hydrogels are ideal flexible interfaces for multimodal health monitoring and integrated diagnosis-therapy systems, owing to their tissue-like mechanical properties, programmable biochemical functions, and hierarchical pores. ...
Color-tunable microfluidic synthesis of FITC/RITC-functionalized POSS hybrid nanoparticles and in vitro biocompatibility assessment [0.03%]
可调色微流控合成FITC/RITC官能化POSS杂化纳米粒子及体外生物相容性评估
Teoman Utku Yegenoglu,Atakan Tevlek,Atalay Bozdogan et al.
Teoman Utku Yegenoglu et al.
Fluorescent nanomaterials are powerful tools for imaging and diagnostics, yet their performance depends critically on the control of particle morphology, stability, and emission characteristics. Polyhedral oligomeric silsesquioxane (POSS) o...
Crosslinker-free PVA hydrogel incorporating a water-soluble Ir(III) photosensitizer for antibacterial photodynamic applications in wound healing [0.03%]
一种用于伤口愈合的不含交联剂的PVA水凝胶，掺入了一种可溶于水的Ir（III）光敏剂以进行抗菌光动力学应用
Tian Luan,Yu Zhang,Weijin Zhu et al.
Tian Luan et al.
Bacterial infections, particularly those involving biofilm formation and antibiotic-resistant pathogens, severely impede wound healing. Photodynamic antibacterial therapy (PDT) offers a non-antibiotic, broad-spectrum antibacterial strategy ...
Precise microfluidic engineering of mRNA lipid nanoparticle-loaded polycaprolactone microcapsules for sustained delivery [0.03%]
精密工程化mRNA脂质纳米颗粒载药聚己内酯微胶囊的长效缓释体系
Hao Bai,Baiqiu Chen,Ziyue Wang et al.
Hao Bai et al.
mRNA therapy holds promise for treating a variety of diseases, but its clinical application faces significant challenges, including rapid degradation in vivo and the need for frequent injections. Lipid nanoparticles (LNPs) are currently the...
Multifunctional polysulfone/strontium silicate composites with tunable properties through silane functionalization [0.03%]
可通过硅烷官能化调节性能的多功能聚砜/锶硅酸盐复合材料
Yun-Ru Huang,Shinn-Jyh Ding
Yun-Ru Huang
The development of osteogenic polymer-based bone implants is increasingly essential for load-bearing applications. Upcycling high-performance polysulfone (PSF) waste is a promising option for environmental sustainability. In this study, PSF...
Melanocortin 1 receptor-targeted peptide-functionalized liposomes for enhanced melanocyte-preferential drug delivery and anti-melanogenic efficacy [0.03%]
针对黑素细胞的MC1R靶向肽修饰脂质体及其药物传输和抗黑色素生成效能研究
Donghan Kim,Hwira Baek,Marta Gonçalves et al.
Donghan Kim et al.
Melanocyte-preferential drug delivery remains challenging due to limited targeting strategies for pigmentary disorders. Here, melanocortin 1 receptor (MC1R)-targeted liposomes (MELA-lipos) functionalized with melanotropic peptides are devel...