Comparative pharmacokinetics for bioequivalence of pramipexole dihydrochloride extended-release tablets in fasting and fed Chinese healthy volunteers: a randomized, open-label, single-dose, crossover study [0.03%]
普拉克索盐酸二盐 Extended Release 薄膜衣片在中国受试者餐前和餐后服用的生物等效性试验：一项随机、开放、单次给药、双周期交叉试验
Qian Chen,Hui-Qing Shi,Yi-Fang Chen et al.
Qian Chen et al.
Background: We aimed to compare pharmacokinetic (PK) profiles and establish bioequivalence between generic and original pramipexole extended-release (ER) tablets in healthy Chinese volunteers under fasting and fed conditi...
Comparison of the anti-inflammatory effects of esomeprazole and fexuprazan in lipopolysaccharide-stimulated RAW 264.7 macrophages [0.03%]
埃索美拉唑和孚西普兰在脂多糖诱导的RAW264.7巨噬细胞中抗炎作用的比较研究
Gi-Beom Ju,Seong Jun Kim,Daye Lee et al.
Gi-Beom Ju et al.
Background: This study aimed to examine the anti-inflammatory effects of esomeprazole (ESO) and fexuprazan (FEXU) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and evaluated voltage-gated potassium channel ...
Combined purslane ethanolic extract and metformin attenuate cognitive dysfunction in HFD/STZ-induced diabetic rats via modulation of oxidative stress, neuroinflammation, and neurotransmitters [0.03%]
蔊菜乙醇提取物联合二甲双胍通过调节氧化应激、神经炎症和神经递质缓解HFD / STZ诱导的糖尿病大鼠认知障碍
Naglaa Bahr,Abd El-Kader M Abd El-Kader,Alaa Eldin Salah Eldin et al.
Naglaa Bahr et al.
Background: Diabetes is associated with a number of significant long-term effects. In this study we consider that purslane which possesses numerous of pharmacological properties, and metformin, an antidiabetic drug, may h...
The potential mechanisms of LCZ696 for anti-hyperthyroid heart disease: an integrative approach of network pharmacology, molecular docking and in vivo verification [0.03%]
LCZ696抗甲状腺心肌病的潜在机制：网络药理学、分子对接和体内验证整合研究
Xianghui Zeng,Lihua Wen,Luoying Liu et al.
Xianghui Zeng et al.
Backgroud: Hyperthyroid heart disease (HHD) is characterized by cardiac remodeling and inflammation, yet targeted therapies remain limited. LCZ696 (sacubitril/valsartan) has demonstrated cardioprotective effects, but its ...
A preliminary investigation of the effects of amentoflavone on TNF-α-induced endothelial activation in HUVECs [0.03%]
染料木素对TNF-α诱导的HUVEC活化影响的初步研究
Fatih Can Turk,Burak Onal,Zulal Celik et al.
Fatih Can Turk et al.
Background: Endothelial dysfunction characterized by cytokine release and adhesion molecule upregulation is a major driver of atherogenesis. Tumor necrosis factor-α (TNF-α) activates NF-κB signaling and increases ICAM-...
Integrative bioinformatics, network toxicology, and molecular docking elucidate molecular mechanisms of ATBC-induced sarcoma progression with experimental validation [0.03%]
整合生物信息学、网络毒理学和分子对接阐明ATBC诱导的肉瘤进展的分子机制并进行实验验证
Yue Wang,Xuan Lin,Yihuang Chen et al.
Yue Wang et al.
Integration of multi-omics and network toxicology reveals TLR4-mediated nephrotoxicity induced by arecoline [0.03%]
多组学和网络毒理学整合揭示了Areca素介导的TLR4介导的肾毒性
Jixiang Yuan,Lichen Chen,Xilong Wang et al.
Jixiang Yuan et al.
CZC54252 overcomes Osimertinib resistance by targeting EGFRC797S mutations [0.03%]
CZC54252通过靶向EGFR C797S突变克服奥希替尼耐药性
Tingnan Ma,Tao Yuan,Yingying Hou et al.
Tingnan Ma et al.
Assessment of the efficiency of new regenerative gel and spray in experimental model systems [0.03%]
新型再生凝胶和喷剂有效性的评估：体外及体内模型研究
Natalia Bezdieniezhnykh,Oleksandra Lykhova,Maryna Borshchevska et al.
Natalia Bezdieniezhnykh et al.
In silico and in vitro insights into the wound-healing potential of syringic acid: protective and regenerative effects on human fibroblasts [0.03%]
丁香酸伤口愈合潜力的计算和实验研究：对人类成纤维细胞的保护及再生效应
Ufuk Okkay,İlkin Kazimov,Irmak Ferah Okkay et al.
Ufuk Okkay et al.
This study aimed to investigate the wound-healing potential of syringic acid (SA) through integrated in silico and in vitro approaches using human dermal fibroblasts (HDFs). Network pharmacology analysis identified myeloperoxidase (MPO), a ...